HLCS and SNX27

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		HLCS	SNX27
Gene Name		holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)	sorting nexin family member 27
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nuclear Lamina Cytoplasm Mitochondrion Cytosol Nuclear Matrix	Immunological Synapse Nucleoplasm Cytoplasm Early Endosome Cytosol Retromer Complex Early Endosome Membrane WASH Complex
	Molecular Function	Biotin-[acetyl-CoA-carboxylase] Ligase Activity Biotin-[methylcrotonoyl-CoA-carboxylase] Ligase Activity Biotin-[methylmalonyl-CoA-carboxytransferase] Ligase Activity Biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] Ligase Activity Protein Binding ATP Binding Biotin Binding Biotin-protein Ligase Activity Enzyme Binding Protein Homodimerization Activity	Protein Binding Phosphatidylinositol-3-phosphate Binding
	Biological Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Biotin Metabolic Process Cell Proliferation Protein Biotinylation Histone Modification Small Molecule Metabolic Process Response To Biotin Histone Biotinylation	Establishment Of Natural Killer Cell Polarity Intracellular Protein Transport Signal Transduction Endosome To Lysosome Transport Endosomal Transport Retrograde Transport, Endosome To Plasma Membrane
Pathways		Metabolism of vitamins and cofactors Defective GIF causes intrinsic factor deficiency Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Biotin transport and metabolism Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism
Drugs		Biotin
Diseases
GWAS
Protein-Protein Interactions		4 interactors: ACACB DDX52 POT1 SNX27	6 interactors: AKT2 APP DGKZ HLCS PNPLA3 SELP
Entrez ID		3141	81609
HPRD ID		08360	11591
Ensembl ID		ENSG00000159267	ENSG00000143376
Uniprot IDs		P50747	Q96L92
PDB IDs			4HAS
Enriched GO Terms of Interacting Partners?		Establishment Of Natural Killer Cell Polarity Positive Regulation Of DNA Strand Elongation Malonyl-CoA Biosynthetic Process Telomere Formation Via Telomerase Positive Regulation Of Helicase Activity Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomerase Activity Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Fatty Acid Oxidation Carnitine Shuttle Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Retrograde Transport, Endosome To Plasma Membrane Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Carnitine Transmembrane Transport Carnitine Transport Biotin Metabolic Process Regulation Of Telomerase Activity Fatty-acyl-CoA Biosynthetic Process Coenzyme A Biosynthetic Process Quaternary Ammonium Group Transport Regulation Of Telomere Maintenance Positive Regulation Of DNA Biosynthetic Process Acetyl-CoA Metabolic Process Negative Regulation Of Fatty Acid Metabolic Process RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Coenzyme A Metabolic Process Endosome To Lysosome Transport Regulation Of Fatty Acid Oxidation Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Lipid Storage Positive Regulation Of Heart Growth Long-chain Fatty Acid Transport Ammonium Transmembrane Transport Lysosomal Transport Regulation Of DNA Biosynthetic Process Positive Regulation Of Organ Growth Negative Regulation Of DNA Replication Regulation Of Lipid Storage Regulation Of Heart Growth Natural Killer Cell Activation Fatty Acid Transport Acyl-CoA Metabolic Process Positive Regulation Of DNA Replication Telomere Maintenance	Platelet Activation Blood Coagulation Hemostasis Platelet Degranulation Regulation Of Cell Cycle Process Protein Biotinylation Histone Biotinylation Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Synaptic Growth At Neuromuscular Junction Response To Biotin Selenium Compound Metabolic Process Collateral Sprouting In Absence Of Injury Activation Of Ral GTPase Activity Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Regulation Of Cell Cycle Collateral Sprouting Axon Midline Choice Point Recognition Acylglycerol Acyl-chain Remodeling Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Glucose Import In Response To Insulin Stimulus Locomotory Behavior Axon Choice Point Recognition Positive Regulation Of Ral GTPase Activity Regulation Of Ral Protein Signal Transduction Positive Regulation Of Platelet Activation Regulation Of Translation Regulation Of Signal Transduction Neuron Remodeling Phosphate-containing Compound Metabolic Process Locomotion Regulation Of Glucose Import In Response To Insulin Stimulus Positive Regulation Of Fatty Acid Beta-oxidation Regulation Of Integrin Activation Lipid Metabolic Process Positive Regulation Of Cell Motility Exocytosis Positive Regulation Of Vesicle Fusion Biotin Metabolic Process Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Glycogen Biosynthetic Process Peripheral Nervous System Myelin Maintenance Leukocyte Tethering Or Rolling Regulation Of Signaling Regulation Of Mitotic Cell Cycle
Tagcloud ?		accumulated cholesterol copyright cyclodextrin derived effectively glycolipids hepatocyte hpgcd hpgcds hydroxypropyl impaired ipsc lysosomal niemann npc phenocopy pick pluripotent powerful progenitors prolonged protected reserved restore rights signature storage tools	40s aav abeta adeno associates decreasing diminishing dissociates downregulation ds elevation encoded establishes glutamate hippocampal impairing invariably microrna modulating presenilin promoted proteolytic recycling reversed rnai secretase trafficking vector
Tagcloud (Difference) ?		accumulated cholesterol copyright cyclodextrin derived effectively glycolipids hepatocyte hpgcd hpgcds hydroxypropyl impaired ipsc lysosomal niemann npc phenocopy pick pluripotent powerful progenitors prolonged protected reserved restore rights signature storage tools	40s aav abeta adeno associates decreasing diminishing dissociates downregulation ds elevation encoded establishes glutamate hippocampal impairing invariably microrna modulating presenilin promoted proteolytic recycling reversed rnai secretase trafficking vector
Tagcloud (Intersection) ?