HLCS and TXNDC15

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		HLCS	TXNDC15
Description		holocarboxylase synthetase	thioredoxin domain containing 15
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nuclear Lamina Cytoplasm Mitochondrion Cytosol Nuclear Matrix	Plasma Membrane Cilium Membrane Cell Projection Ciliary Membrane
	Molecular Function	Nucleotide Binding Catalytic Activity Biotin--[biotin Carboxyl-carrier Protein] Ligase Activity Protein Binding ATP Binding Biotin Binding Ligase Activity Enzyme Binding Identical Protein Binding	Protein Binding
	Biological Process	Biotin Metabolic Process Post-translational Protein Modification Response To Biotin	Cell Projection Organization Positive Regulation Of Smoothened Signaling Pathway Cilium Assembly
Pathways		Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency
Drugs		Biotin
Diseases		Holocarboxylase synthetase deficiency
GWAS		Developmental language disorder ( 27016271) Developmental language disorder (linguistic errors) ( 27016271) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intracranial aneurysm ( 29531279) Night sleep phenotypes ( 27126917) Red blood cell count ( 32888494) Seasonality and depression ( 30217971)	Blood protein levels ( 30072576) Height ( 18391951)
Interacting Genes		10 interacting genes: ACACB ANKRD29 DDX52 KRTAP5-9 MED19 POT1 QKI SARS2 SNX27 TXNDC15	4 interacting genes: ASPH HLCS UBC ZDHHC17
Entrez ID		3141	79770
HPRD ID		08360	08658
Ensembl ID		ENSG00000159267	ENSG00000113621
Uniprot IDs		A0A8C8QSB1 P50747	Q96J42
PDB IDs
Enriched GO Terms of Interacting Partners?			Peptidyl-aspartic Acid 3-dioxygenase Activity Biotin--[biotin Carboxyl-carrier Protein] Ligase Activity Response To Biotin Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Activation Of Store-operated Calcium Channel Activity Biotin Metabolic Process Biotin Binding Protein-cysteine S-myristoyltransferase Activity Positive Regulation Of Store-operated Calcium Channel Activity Protein-cysteine S-stearoyltransferase Activity Cortical Endoplasmic Reticulum Sarcoplasmic Reticulum Lumen Junctional Sarcoplasmic Reticulum Membrane Positive Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cell Communication By Electrical Coupling Regulation Of Calcium Ion Transport Into Cytosol Detection Of Calcium Ion Protein Modification Process Nuclear Lamina Protein Tag Activity Lipoprotein Transport Regulation Of Neurotrophin TRK Receptor Signaling Pathway Protein Palmitoylation Palmitoyltransferase Activity Regulation Of Modification Of Synaptic Structure Golgi-associated Vesicle Membrane Protein-cysteine S-palmitoyltransferase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Positive Regulation Of Cation Channel Activity Calcium Channel Complex
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