HLCS

Description		holocarboxylase synthetase
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nuclear Lamina Cytoplasm Mitochondrion Cytosol Nuclear Matrix
	Molecular Function	Nucleotide Binding Catalytic Activity Biotin--[biotin Carboxyl-carrier Protein] Ligase Activity Protein Binding ATP Binding Biotin Binding Ligase Activity Enzyme Binding Identical Protein Binding
	Biological Process	Biotin Metabolic Process Post-translational Protein Modification Response To Biotin
Pathways		Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency
Drugs		Biotin
Diseases		Holocarboxylase synthetase deficiency
GWAS		Developmental language disorder ( 27016271) Developmental language disorder (linguistic errors) ( 27016271) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intracranial aneurysm ( 29531279) Night sleep phenotypes ( 27126917) Red blood cell count ( 32888494) Seasonality and depression ( 30217971)
Novel Interacting Genes		9 novel interacting genes: BACH1 IFNAR2 IFNGR2 IFT20 LANCL2 NGB SOD1 TGM3 WIPF1
Interacting Genes		10 interacting genes: ACACB ANKRD29 DDX52 KRTAP5-9 MED19 POT1 QKI SARS2 SNX27 TXNDC15
Entrez ID		3141
HPRD ID		08360
Ensembl ID		ENSG00000159267
Uniprot IDs		A0A8C8QSB1 P50747
PDB IDs
Enriched GO Terms of Interacting Partners?
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