HLCS

Name	holocarboxylase synthetase
Structure	No pdb structure
Novel Interactors	9 novel interactors: BACH1 IFNAR2 IFNGR2 IFT20 LANCL2 NGB SOD1 TGM3 WIPF1
Interactors	10 interactors: ACACB ANKRD29 DDX52 KRTAP5-9 MED19 POT1 QKI SARS2 SNX27 TXNDC15
GO Annotations	Cellular Component	Chromatin Nuclear Lamina Cytoplasm Mitochondrion Cytosol Nuclear Matrix
	Molecular Function	Nucleotide Binding Catalytic Activity Biotin--[biotin Carboxyl-carrier Protein] Ligase Activity Protein Binding ATP Binding Biotin Binding Ligase Activity Enzyme Binding Identical Protein Binding
	Biological Process	Biotin Metabolic Process Post-translational Protein Modification Response To Biotin
Pathways	Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency
Drugs	Biotin
Diseases	Holocarboxylase synthetase deficiency
GWAS	Developmental language disorder ( 27016271 ) Developmental language disorder (linguistic errors) ( 27016271 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Intracranial aneurysm ( 29531279 ) Night sleep phenotypes ( 27126917 ) Red blood cell count ( 32888494 ) Seasonality and depression ( 30217971 )
Entrez ID	3141
HPRD ID	08360
Ensembl ID	ENSG00000159267
Uniprot IDs	A0A8C8QSB1 P50747
PDB IDs	Not available