HLCS and ACACB

Number of citations: 0 (PubMedID 20085763)
Data Source: BioGRID (enzymatic study)

		HLCS	ACACB
Name		holocarboxylase synthetase	acetyl-CoA carboxylase beta
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nuclear Lamina Cytoplasm Mitochondrion Cytosol Nuclear Matrix	Nucleus Mitochondrion Mitochondrial Outer Membrane Cytosol Mitochondrial Fatty Acid Beta-oxidation Multienzyme Complex
	Molecular Function	Nucleotide Binding Catalytic Activity Biotin--[biotin Carboxyl-carrier Protein] Ligase Activity Protein Binding ATP Binding Biotin Binding Ligase Activity Enzyme Binding Identical Protein Binding	Nucleotide Binding Catalytic Activity Acetyl-CoA Carboxylase Activity Protein Binding ATP Binding Biotin Binding Ligase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Biotin Metabolic Process Post-translational Protein Modification Response To Biotin	Acetyl-CoA Metabolic Process Pentose-phosphate Shunt Purine Nucleotide Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Acyl-CoA Metabolic Process Response To Nutrient Response To Xenobiotic Stimulus Positive Regulation Of Lipid Storage Regulation Of Glucose Metabolic Process Fatty Acid Oxidation Response To Nutrient Levels Negative Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of Fatty Acid Oxidation D-glucose Import Lactic Acid Secretion Negative Regulation Of Lipid Catabolic Process Protein Homotetramerization Fatty Acid Homeostasis Positive Regulation Of Heart Growth Response To Caloric Restriction Tricarboxylic Acid Metabolic Process Intracellular Aspartate Homeostasis Intracellular Glutamate Homeostasis Energy Homeostasis Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Malonyl-CoA Biosynthetic Process
Pathways		Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency	ChREBP activates metabolic gene expression Biotin transport and metabolism Carnitine shuttle Activation of gene expression by SREBF (SREBP)
Drugs		Biotin	Biotin Adenine Soraphen A 2-[4-(2,4-Dichlorophenoxy)Phenoxy]Propanoic Acid Haloxyfop-P
Diseases		Holocarboxylase synthetase deficiency	None
GWAS		Developmental language disorder ( 27016271 ) Developmental language disorder (linguistic errors) ( 27016271 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Intracranial aneurysm ( 29531279 ) Night sleep phenotypes ( 27126917 ) Red blood cell count ( 32888494 ) Seasonality and depression ( 30217971 )	Fish- and plant-related diet ( 32066663 ) Invasive cervical cancer ( 33794208 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Oily fish consumption ( 32066663 ) Pork consumption ( 32066663 ) Triglyceride levels ( 32203549 ) Triglycerides ( 30275531 )
Interacting Genes		10 interacting genes: ACACB ANKRD29 DDX52 KRTAP5-9 MED19 POT1 QKI SARS2 SNX27 TXNDC15	4 interacting genes: HLCS PEX14 PRKAA2 USP7
Entrez ID		3141	32
HPRD ID		08360	07044
Ensembl ID		ENSG00000159267	ENSG00000076555
Uniprot IDs		A0A8C8QSB1 P50747	O00763
PDB IDs		Not available	2DN8 2HJW 2KCC 3FF6 3GID 3GLK 3JRW 3JRX 3TDC 4HQ6 5KKN
GO Terms Enriched among Interactors		None	Post-translational Protein Modification Protein Modification Process Response To Nutrient Levels Negative Regulation Of TORC1 Signaling TORC1 Signaling Biotin--[biotin Carboxyl-carrier Protein] Ligase Activity Peroxisome Transport Along Microtubule Protein Modification By Small Protein Conjugation Protein Ubiquitination Regulation Of TORC1 Signaling Regulation Of Circadian Rhythm Negative Regulation Of TOR Signaling TOR Signaling Response To Biotin Regulation Of TOR Signaling [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Histone H2BS36 Kinase Activity Biotin Metabolic Process Protein Metabolic Process Protein Import Into Peroxisome Matrix, Translocation Regulation Of DNA-binding Transcription Factor Activity Cellular Response To Oxidative Stress Protein Import Into Peroxisome Matrix, Docking Peroxisomal Importomer Complex Positive Regulation Of Autophagy Protein Localization To Lipid Droplet Symbiont-mediated Disruption Of Host Cell PML Body Biotin Binding Protein Import Into Peroxisome Matrix, Substrate Release Negative Regulation Of Hepatocyte Apoptotic Process Rhythmic Process Negative Regulation Of Tubulin Deacetylation Cellular Response To Nutrient Levels AMP-activated Protein Kinase Activity Regulation Of Establishment Of Protein Localization To Telomere Cellular Response To Chemical Stress Lipid Droplet Disassembly Regulation Of Tubulin Deacetylation Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Retrograde Transport, Endosome To Golgi Monoubiquitinated Protein Deubiquitination Regulation Of Small Molecule Metabolic Process Protein Import Into Peroxisome Matrix, Receptor Recycling Phosphatidylethanolamine Biosynthetic Process Response To Oxidative Stress Regulation Of Protein Deacetylation Nucleotide-activated Protein Kinase Complex Regulation Of Stress Granule Assembly DNA Alkylation Repair Protein Unfolding