COPB1 and HLA-DPB1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		COPB1	HLA-DPB1
Gene Name		coatomer protein complex, subunit beta 1	major histocompatibility complex, class II, DP beta 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Golgi-associated Vesicle Cytosol Plasma Membrane Membrane COPI Vesicle Coat Intracellular Membrane-bounded Organelle	Golgi Membrane Lysosomal Membrane Plasma Membrane Cell Surface Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Structural Molecule Activity Protein Binding	Peptide Antigen Binding
	Biological Process	Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To ER Intra-Golgi Vesicle-mediated Transport Viral Process COPI Coating Of Golgi Vesicle Membrane Organization	Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Costimulation Positive Regulation Of Interferon-gamma Production Positive Regulation Of T Cell Proliferation T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Interferon-gamma-mediated Signaling Pathway
Pathways		COPI Mediated Transport Golgi to ER Retrograde Transport	Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs
Diseases
GWAS			Aspirin exacerbated respiratory disease in asthmatics ( 23180272) Hepatitis B ( 21750111 19349983) Hepatitis B (viral clearance) ( 22737229) Hepatitis B vaccine response ( 21764829) Nephropathy ( 21399633) Systemic sclerosis ( 21779181) Wegener's granulomatosis ( 23740775)
Protein-Protein Interactions		32 interactors: ADAM19 APP ARCN1 ARF1 COPE COPG1 COPG2 ERBB2IP FOXB1 GRB2 HLA-DPB1 HLA-G ID1 IRAK3 KCNK3 KDELR1 LZTS2 NUB1 PDGFRB PRKCE RGS2 RGS4 RHOQ SERTAD1 SNTA1 TANK TAPBP TMED10 TRIM37 UBQLN4 VPS18 XRCC6	7 interactors: CD74 COPB1 HLA-DPA1 LZTS2 ROBO2 RTN4 TRIP6
Entrez ID		1315	3115
HPRD ID		02981	00832
Ensembl ID		ENSG00000129083
Uniprot IDs		P53618	I4EC15 P04440
PDB IDs			3LQZ
Enriched GO Terms of Interacting Partners?		Retrograde Vesicle-mediated Transport, Golgi To ER COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Golgi Vesicle Budding Vesicle Targeting, To, From Or Within Golgi Vesicle Targeting Localization Within Membrane Intracellular Transport Golgi Vesicle Transport Membrane Budding Vesicle-mediated Transport Establishment Of Localization In Cell Innate Immune Response Cellular Localization Immune Response-regulating Signaling Pathway Regulation Of Cytoskeleton Organization Immune Response Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Immune System Process Regulation Of MAPK Cascade Regulation Of Actin Filament-based Process Regulation Of Organelle Organization Regulation Of Phosphorylation Defense Response Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Establishment Of Organelle Localization ERBB Signaling Pathway Regulation Of Protein Metabolic Process Establishment Of Protein Localization Regulation Of Phosphorus Metabolic Process Regulation Of Actin Cytoskeleton Organization Regulation Of Immune Response Protein Localization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Intracellular Protein Transport Positive Regulation Of Immune Response Negative Regulation Of MAP Kinase Activity Transport Organelle Localization Regulation Of Phospholipase Activity Regulation Of Immune System Process Antigen Processing And Presentation Of Peptide Antigen Cellular Copper Ion Homeostasis Cellular Protein Localization Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation	Regulation Of Locomotion Neuron Recognition Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Macrophage Migration Inhibitory Factor Signaling Pathway Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Cell Migration Cell Recognition Negative Regulation Of Negative Chemotaxis Regulation Of Cell Motility Signal Transduction Regulation Of Chemotaxis Regulation Of Cellular Component Movement Apoptotic Process Involved In Luteolysis Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Axonogenesis Signaling Cellular Response To Organic Substance Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Regulation Of Negative Chemotaxis Negative Regulation Of Mature B Cell Apoptotic Process Cell Communication Regulation Of Behavior Regulation Of Protein Localization To Nucleus Axon Midline Choice Point Recognition Luteolysis Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Axon Choice Point Recognition Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Cell-cell Adhesion Endoplasmic Reticulum Tubular Network Organization Cellular Response To Stimulus Olfactory Bulb Interneuron Development Antigen Processing And Presentation Telencephalon Development Spindle Midzone Assembly Positive Thymic T Cell Selection Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Negative Regulation Of B Cell Apoptotic Process Kidney Development Response To Organic Substance COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Tagcloud ?		ca037 ca530 cadd chlamydiaceae chlamydophila copd1 copd2 inca incc pkn5 psittaci scc1 scc2 scc3 sctc sctd sctj sctl sctn sctq sctr scts sctt sctu sctv sctw t3s t3ss tarp
Tagcloud (Difference) ?		ca037 ca530 cadd chlamydiaceae chlamydophila copd1 copd2 inca incc pkn5 psittaci scc1 scc2 scc3 sctc sctd sctj sctl sctn sctq sctr scts sctt sctu sctv sctw t3s t3ss tarp
Tagcloud (Intersection) ?