HLA-F and CHRM5

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		HLA-F	CHRM5
Description		major histocompatibility complex, class I, F	cholinergic receptor muscarinic 5
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class Ib Protein Complex MHC Class I Protein Complex Recycling Endosome Membrane Lumenal Side Of Endoplasmic Reticulum Membrane	Plasma Membrane Membrane Dendrite Synapse Postsynaptic Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Beta-2-microglobulin Binding Peptide Antigen Binding TAP1 Binding TAP2 Binding 14-3-3 Protein Binding	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Acetylcholine Receptor Activity
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Immune System Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Negative Regulation Of T Cell Cytokine Production Negative Regulation Of Natural Killer Cell Cytokine Production Positive Regulation Of Natural Killer Cell Cytokine Production Immune Response Negative Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Natural Killer Cell Degranulation Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity	Gastric Acid Secretion Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Dopamine Transport Transmission Of Nerve Impulse Regulation Of Phosphatidylinositol Dephosphorylation Acetylcholine Receptor Signaling Pathway
Pathways		ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Interferon gamma signaling Interferon alpha/beta signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Muscarinic acetylcholine receptors G alpha (q) signalling events
Drugs			Ziprasidone Amitriptyline Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Loxapine Meperidine Imipramine Gallamine triethiodide Darifenacin Nortriptyline Amoxapine Cinnarizine Atropine Nicardipine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Propiomazine Brompheniramine Maprotiline Methantheline Glycopyrronium Bethanechol Tolterodine Promethazine Doxepin Desipramine Ketamine Quetiapine Aripiprazole Chlorprothixene Methotrimeprazine Tiotropium Solifenacin ALKS 27 Fesoterodine Methacholine Aclidinium Umeclidinium Dosulepin Etoperidone Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 22412388) Hip circumference adjusted for BMI ( 34021172) Lung cancer ( 31577861) Mixed cellularity Hodgkin lymphoma ( 29196614) Nasopharyngeal carcinoma ( 19664746) Offspring birth weight ( 31043758)	Malaria ( 31844061)
Interacting Genes		5 interacting genes: B2M CHRM5 LILRB1 LILRB2 TAP1	31 interacting genes: ASPH ASTN2 ATP2A2 ATP9A CBFB CD82 EPB41L1 EPC1 ERCC1 GJB6 GOLGA8A GPRASP1 HLA-F MAP3K1 MSMO1 MYH7 NLE1 NPAS3 PRSS16 REEP5 RGS7 RTN1 SLC2A6 SLC5A6 SLC6A8 SMAD6 SNCA SPNS1 STARD3NL TMEM161A USP33
Entrez ID		3134	1133
HPRD ID		00884	00331
Ensembl ID		ENSG00000204642	ENSG00000184984
Uniprot IDs		A0A0G2JH66 D0EV57 P30511 Q5JZ47 Q5JZ48	P08912 Q8IVW0
PDB IDs		5IUE 5KNM	6OL9
Enriched GO Terms of Interacting Partners?		MHC Class Ib Protein Binding MHC Class I Protein Binding MHC Class Ib Protein Complex Binding Adaptive Immune Response Fc Receptor Mediated Inhibitory Signaling Pathway Inhibitory MHC Class I Receptor Activity MHC Class I Peptide Loading Complex Peptide Antigen Assembly With MHC Class I Protein Complex Negative Regulation Of Monoatomic Ion Transport Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Interleukin-10-mediated Signaling Pathway Immune Response-inhibiting Signal Transduction Regulation Of Dendritic Cell Differentiation Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Protein Homodimerization Activity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Protein Phosphatase 1 Binding Antigen Processing And Presentation Of Endogenous Antigen Positive Regulation Of T Cell Activation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Positive Regulation Of Leukocyte Cell-cell Adhesion Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Regulation Of Metal Ion Transport Negative Regulation Of Calcium Ion Transport Immune Response Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Antigen Processing And Presentation Of Peptide Antigen Regulation Of Monoatomic Ion Transport Negative Regulation Of Transport Regulation Of Hemopoiesis Negative Regulation Of Endocytosis Defense Response Cellular Response To Lipid Negative Regulation Of T Cell Proliferation Phagocytic Vesicle Membrane Positive Regulation Of Cytokine Production Positive Regulation Of Cell Adhesion Positive Regulation Of Cytokine Production Involved In Immune Response Regulation Of Cell-cell Adhesion Amyloid-beta Binding Regulation Of Lymphocyte Activation Negative Regulation Of Lymphocyte Proliferation	Sarcoplasmic Reticulum Membrane Transition Between Fast And Slow Fiber Negative Regulation Of Exocytosis Sarcoplasmic Reticulum Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Skeletal Muscle Adaptation Supramolecular Fiber Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Transmembrane Transporter Activity Regulation Of Exocytosis Endoplasmic Reticulum Membrane Organization
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