HLA-F and LILRB2

Number of citations of the paper that reports this interaction (PMID 11169396)
17

Data Source:
HPRD (in vitro, in vivo)

		HLA-F	LILRB2
Gene Name		major histocompatibility complex, class I, F	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Receptor Binding Peptide Antigen Binding TAP1 Binding TAP2 Binding	Receptor Activity Protein Binding Protein Phosphatase 1 Binding MHC Class Ib Protein Binding Inhibitory MHC Class I Receptor Activity MHC Class I Protein Binding Cell Adhesion Molecule Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway	Negative Regulation Of Antigen Processing And Presentation Positive Regulation Of T Cell Tolerance Induction Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Inhibitory Signaling Pathway Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Interleukin-6 Production Heterotypic Cell-cell Adhesion Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Regulatory T Cell Differentiation Regulation Of Immune Response Negative Regulation Of Calcium Ion Transport Cellular Response To Lipopolysaccharide Regulation Of Dendritic Cell Differentiation
Pathways		Interferon gamma signaling Interferon Signaling Endosomal/Vacuolar pathway Cytokine Signaling in Immune system Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS		Crohn's disease ( 22412388) Nasopharyngeal carcinoma ( 19664746)	HDL cholesterol ( 20686565)
Protein-Protein Interactions		4 interactors: B2M LILRB1 LILRB2 TAP1	7 interactors: FCGR1A HLA-A HLA-B HLA-C HLA-F HLA-G PTPN6
Entrez ID		3134	10288
HPRD ID		00884	11994
Ensembl ID		ENSG00000204642	ENSG00000131042
Uniprot IDs		P30511 Q5JZ48	A2IXV5 A8MU67 C9JF29 Q8N423
PDB IDs			2DYP 2GW5 4LLA
Enriched GO Terms of Interacting Partners?		Fc Receptor Mediated Inhibitory Signaling Pathway Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Immune Response-inhibiting Signal Transduction Regulation Of Dendritic Cell Differentiation Defense Response Response To Molecule Of Bacterial Origin Negative Regulation Of Calcium Ion Transport Response To Bacterium Negative Regulation Of T Cell Proliferation Single Organismal Cell-cell Adhesion Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Regulation Of Defense Response To Virus Immune System Process Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Ion Transport Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion Response To Other Organism Regulation Of Leukocyte Mediated Cytotoxicity Response To Biotic Stimulus Negative Regulation Of Homotypic Cell-cell Adhesion Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Negative Regulation Of Transforming Growth Factor-beta Secretion Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of Gamma-delta T Cell Activation Involved In Immune Response Negative Regulation Of Interferon-beta Secretion Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of T Cell Proliferation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Cellular Response To Lipopolysaccharide Negative Regulation Of Leukocyte Activation Cellular Response To Molecule Of Bacterial Origin Negative Regulation Of Osteoclast Development Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Cytosol To ER Transport Negative Regulation Of Interleukin-12 Secretion Regulation Of Calcium Ion Transport Regulation Of Adaptive Immune Response Negative Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Response To Stress Regulation Of Interleukin-12 Secretion Negative Regulation Of Interleukin-10 Secretion Negative Regulation Of Dendritic Cell Apoptotic Process	Interferon-gamma-mediated Signaling Pathway Cellular Response To Interferon-gamma Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Response To Interferon-gamma Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Response To Type I Interferon Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of T Cell Mediated Cytotoxicity Regulation Of Adaptive Immune Response Positive Regulation Of Leukocyte Mediated Cytotoxicity Cytokine-mediated Signaling Pathway Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Regulation Of Leukocyte Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Cellular Response To Cytokine Stimulus Antigen Processing And Presentation Positive Regulation Of Immune Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Response To Cytokine Positive Regulation Of Adaptive Immune Response Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Immune Response Regulation Of Immune System Process Defense Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Antigen Cellular Response To Organic Substance Immune System Process Response To Organic Substance Protection From Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Cell Surface Receptor Signaling Pathway Response To Stress Negative Regulation Of Immune System Process Regulation Of Dendritic Cell Differentiation Negative Regulation Of Immune Response Detection Of Bacterium Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Signal Transduction Detection Of Biotic Stimulus
Tagcloud ?			abilities acetylcholine adrenergic alpha7 alpha7nachr ars bindings characters deterioration drivers eph exact fcgamma fcgammariib immunoglobulin ltp neurotrophin nicotinic oligomeric ortholog p75ntr pirb presumed prion prpc rescuing spine summarizes synapse
Tagcloud (Difference) ?			abilities acetylcholine adrenergic alpha7 alpha7nachr ars bindings characters deterioration drivers eph exact fcgamma fcgammariib immunoglobulin ltp neurotrophin nicotinic oligomeric ortholog p75ntr pirb presumed prion prpc rescuing spine summarizes synapse
Tagcloud (Intersection) ?