HLA-F

Gene Name		major histocompatibility complex, class I, F
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Receptor Binding Peptide Antigen Binding TAP1 Binding TAP2 Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway
Pathways		Interferon gamma signaling Interferon Signaling Endosomal/Vacuolar pathway Cytokine Signaling in Immune system Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System
Drugs
Diseases
GWAS		Crohn's disease ( 22412388) Nasopharyngeal carcinoma ( 19664746)
Protein-protein Interactions		4 interactors: B2M LILRB1 LILRB2 TAP1
Entrez ID		3134
HPRD ID		00884
Ensembl ID		ENSG00000204642
Uniprot IDs		P30511 Q5JZ48
PDB IDs
Enriched GO Terms of Interacting Partners?		Fc Receptor Mediated Inhibitory Signaling Pathway Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Immune Response-inhibiting Signal Transduction Regulation Of Dendritic Cell Differentiation Defense Response Response To Molecule Of Bacterial Origin Negative Regulation Of Calcium Ion Transport Response To Bacterium Negative Regulation Of T Cell Proliferation Single Organismal Cell-cell Adhesion Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Regulation Of Defense Response To Virus Immune System Process Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Ion Transport Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion Response To Other Organism Regulation Of Leukocyte Mediated Cytotoxicity Response To Biotic Stimulus Negative Regulation Of Homotypic Cell-cell Adhesion Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Negative Regulation Of Transforming Growth Factor-beta Secretion Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of Gamma-delta T Cell Activation Involved In Immune Response Negative Regulation Of Interferon-beta Secretion Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of T Cell Proliferation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Cellular Response To Lipopolysaccharide Negative Regulation Of Leukocyte Activation Cellular Response To Molecule Of Bacterial Origin Negative Regulation Of Osteoclast Development Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Cytosol To ER Transport Negative Regulation Of Interleukin-12 Secretion Regulation Of Calcium Ion Transport Regulation Of Adaptive Immune Response Negative Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Response To Stress Regulation Of Interleukin-12 Secretion Negative Regulation Of Interleukin-10 Secretion Negative Regulation Of Dendritic Cell Apoptotic Process
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