HLA-F

Description		major histocompatibility complex, class I, F
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class Ib Protein Complex MHC Class I Protein Complex Recycling Endosome Membrane Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Beta-2-microglobulin Binding Peptide Antigen Binding TAP1 Binding TAP2 Binding 14-3-3 Protein Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Immune System Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Negative Regulation Of T Cell Cytokine Production Negative Regulation Of Natural Killer Cell Cytokine Production Positive Regulation Of Natural Killer Cell Cytokine Production Immune Response Negative Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Natural Killer Cell Degranulation Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
Pathways		ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Interferon gamma signaling Interferon alpha/beta signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 22412388) Hip circumference adjusted for BMI ( 34021172) Lung cancer ( 31577861) Mixed cellularity Hodgkin lymphoma ( 29196614) Nasopharyngeal carcinoma ( 19664746) Offspring birth weight ( 31043758)
Interacting Genes		5 interacting genes: B2M CHRM5 LILRB1 LILRB2 TAP1
Entrez ID		3134
HPRD ID		00884
Ensembl ID		ENSG00000204642
Uniprot IDs		A0A0G2JH66 D0EV57 P30511 Q5JZ47 Q5JZ48
PDB IDs		5IUE 5KNM
Enriched GO Terms of Interacting Partners?		MHC Class Ib Protein Binding MHC Class I Protein Binding MHC Class Ib Protein Complex Binding Adaptive Immune Response Fc Receptor Mediated Inhibitory Signaling Pathway Inhibitory MHC Class I Receptor Activity MHC Class I Peptide Loading Complex Peptide Antigen Assembly With MHC Class I Protein Complex Negative Regulation Of Monoatomic Ion Transport Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Interleukin-10-mediated Signaling Pathway Immune Response-inhibiting Signal Transduction Regulation Of Dendritic Cell Differentiation Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Protein Homodimerization Activity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Protein Phosphatase 1 Binding Antigen Processing And Presentation Of Endogenous Antigen Positive Regulation Of T Cell Activation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Positive Regulation Of Leukocyte Cell-cell Adhesion Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Regulation Of Metal Ion Transport Negative Regulation Of Calcium Ion Transport Immune Response Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Antigen Processing And Presentation Of Peptide Antigen Regulation Of Monoatomic Ion Transport Negative Regulation Of Transport Regulation Of Hemopoiesis Negative Regulation Of Endocytosis Defense Response Cellular Response To Lipid Negative Regulation Of T Cell Proliferation Phagocytic Vesicle Membrane Positive Regulation Of Cytokine Production Positive Regulation Of Cell Adhesion Positive Regulation Of Cytokine Production Involved In Immune Response Regulation Of Cell-cell Adhesion Amyloid-beta Binding Regulation Of Lymphocyte Activation Negative Regulation Of Lymphocyte Proliferation
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