HLA-F and LILRB1

Number of citations of the paper that reports this interaction (PMID 11169396)
17

Data Source:
HPRD (in vivo)

		HLA-F	LILRB1
Gene Name		major histocompatibility complex, class I, F	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Extracellular Region Cytoplasm Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Receptor Binding Peptide Antigen Binding TAP1 Binding TAP2 Binding	Protein Phosphatase 1 Binding HLA-A Specific Inhibitory MHC Class I Receptor Activity HLA-B Specific Inhibitory MHC Class I Receptor Activity MHC Class I Receptor Activity SH2 Domain Binding MHC Class I Protein Binding Protein Homodimerization Activity
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway	Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host T Cell Proliferation Involved In Immune Response Negative Regulation Of Cytokine Secretion Involved In Immune Response Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Inhibitory Signaling Pathway Signal Transduction Response To Virus Positive Regulation Of Gene Expression Negative Regulation Of Serotonin Secretion Receptor Internalization Interferon-gamma Production Negative Regulation Of Interferon-gamma Production Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Interferon-beta Secretion Negative Regulation Of T Cell Proliferation Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Interferon-gamma Biosynthetic Process Negative Regulation Of Cell Cycle Negative Regulation Of Endocytosis Positive Regulation Of Cytolysis Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Alpha-beta T Cell Activation Regulation Of Immune Response Defense Response To Virus Negative Regulation Of Calcium Ion Transport Cellular Response To Lipopolysaccharide Interferon-gamma Secretion Dendritic Cell Differentiation Negative Regulation Of Dendritic Cell Apoptotic Process Negative Regulation Of Interleukin-10 Secretion Negative Regulation Of Interleukin-12 Secretion Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Gamma-delta T Cell Activation Involved In Immune Response Negative Regulation Of Dendritic Cell Differentiation Negative Regulation Of Transforming Growth Factor-beta Secretion Negative Regulation Of Osteoclast Development
Pathways		Interferon gamma signaling Interferon Signaling Endosomal/Vacuolar pathway Cytokine Signaling in Immune system Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS		Crohn's disease ( 22412388) Nasopharyngeal carcinoma ( 19664746)
Protein-Protein Interactions		4 interactors: B2M LILRB1 LILRB2 TAP1	6 interactors: B2M HLA-A HLA-B HLA-C HLA-F HLA-G
Entrez ID		3134	10859
HPRD ID		00884	07273
Ensembl ID		ENSG00000204642	ENSG00000104972
Uniprot IDs		P30511 Q5JZ48	A8MVE2 Q8NHL6
PDB IDs			1G0X 1P7Q 1UFU 1UGN 1VDG 3D2U 4LL9
Enriched GO Terms of Interacting Partners?		Fc Receptor Mediated Inhibitory Signaling Pathway Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Immune Response-inhibiting Signal Transduction Regulation Of Dendritic Cell Differentiation Defense Response Response To Molecule Of Bacterial Origin Negative Regulation Of Calcium Ion Transport Response To Bacterium Negative Regulation Of T Cell Proliferation Single Organismal Cell-cell Adhesion Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Regulation Of Defense Response To Virus Immune System Process Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Ion Transport Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion Response To Other Organism Regulation Of Leukocyte Mediated Cytotoxicity Response To Biotic Stimulus Negative Regulation Of Homotypic Cell-cell Adhesion Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Negative Regulation Of Transforming Growth Factor-beta Secretion Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of Gamma-delta T Cell Activation Involved In Immune Response Negative Regulation Of Interferon-beta Secretion Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of T Cell Proliferation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Cellular Response To Lipopolysaccharide Negative Regulation Of Leukocyte Activation Cellular Response To Molecule Of Bacterial Origin Negative Regulation Of Osteoclast Development Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Cytosol To ER Transport Negative Regulation Of Interleukin-12 Secretion Regulation Of Calcium Ion Transport Regulation Of Adaptive Immune Response Negative Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Response To Stress Regulation Of Interleukin-12 Secretion Negative Regulation Of Interleukin-10 Secretion Negative Regulation Of Dendritic Cell Apoptotic Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Cellular Response To Interferon-gamma Response To Interferon-gamma Regulation Of Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Antigen Processing And Presentation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Positive Regulation Of Immune Response Response To Cytokine Innate Immune Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Regulation Of Immune Response Positive Regulation Of Immune System Process Antigen Processing And Presentation Of Endogenous Antigen Immune Response Regulation Of Immune System Process Defense Response Protection From Natural Killer Cell Mediated Cytotoxicity Cellular Response To Organic Substance Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Immune System Process Response To Organic Substance Regulation Of Dendritic Cell Differentiation Viral Process Cell Surface Receptor Signaling Pathway Response To Stress Detection Of Bacterium Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Defense Response To Virus By Virus Detection Of Biotic Stimulus Negative Regulation Of Innate Immune Response Negative Regulation Of Immune System Process Regulation Of Interleukin-12 Production
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