KLRD1 and HLA-G

Number of citations of the paper that reports this interaction (PMID 9405670)
5

Data Source:
HPRD (in vivo)

		KLRD1	HLA-G
Gene Name		killer cell lectin-like receptor subfamily D, member 1	major histocompatibility complex, class I, G
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Gene Ontology Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex	Golgi Membrane Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding MHC Class I Protein Complex Binding Carbohydrate Binding Protein Antigen Binding	Receptor Binding Peptide Antigen Binding Protein Homodimerization Activity
	Biological Process	Natural Killer Cell Mediated Immunity Cell Surface Receptor Signaling Pathway Innate Immune Response Regulation Of Immune Response	Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Positive Regulation Of T Cell Tolerance Induction Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Cellular Defense Response Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-12 Production Negative Regulation Of T Cell Proliferation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Positive Regulation Of Regulatory T Cell Differentiation Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Negative Regulation Of Dendritic Cell Differentiation
Pathways		DAP12 signaling DAP12 interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System Innate Immune System	Interferon gamma signaling Interferon Signaling Endosomal/Vacuolar pathway Cytokine Signaling in Immune system Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Antigen Presentation: Folding, assembly and peptide loading of class I MHC Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System
Drugs
Diseases
GWAS			Crohn's disease ( 22412388) IgE levels ( 22075330) Rheumatoid arthritis ( 21653640)
Protein-Protein Interactions		6 interactors: HLA-B HLA-E HLA-G KLRC1 KLRC2 KLRC3	9 interactors: B2M CD8A COPB1 KIR2DL4 KLRD1 LILRB1 LILRB2 TAP1 TAP2
Entrez ID		3824	3135
HPRD ID		04204	00834
Ensembl ID		ENSG00000134539	ENSG00000204632
Uniprot IDs		F6WZH4 Q13241 Q53ZY6	P17693 Q29897 Q31611 Q5RJ85 Q6DU14
PDB IDs		1B6E 3BDW 3CDG 3CII	1YDP 2D31 2DYP 3BZE 3CDG 3CII 3KYN 3KYO
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Protection From Natural Killer Cell Mediated Cytotoxicity Cellular Defense Response Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Response To Type I Interferon Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Interferon-gamma-mediated Signaling Pathway Regulation Of Dendritic Cell Differentiation Positive Regulation Of Adaptive Immune Response Cellular Response To Interferon-gamma Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Defense Response Response To Interferon-gamma Antigen Processing And Presentation Of Endogenous Antigen Regulation Of Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Innate Immune Response Regulation Of Immune Response Antigen Processing And Presentation Negative Regulation Of Innate Immune Response Negative Regulation Of Immune System Process Cytokine-mediated Signaling Pathway Immune Response Regulation Of Interleukin-12 Production Regulation Of Immune System Process Signal Transduction Signaling Cell Communication Cellular Response To Cytokine Stimulus Positive Regulation Of Immune Response Response To Stress Negative Regulation Of Immune Response Response To Cytokine Cellular Response To Stimulus Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Immune System Process Positive Regulation Of Immune System Process Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Positive Regulation Of Regulatory T Cell Differentiation	Regulation Of Immune System Process Defense Response Cytosol To ER Transport Regulation Of Immune Response Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Fc Receptor Mediated Inhibitory Signaling Pathway Intracellular Transport Of Viral Protein In Host Cell Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Immune System Process Immune Response-inhibiting Signal Transduction Antigen Processing And Presentation Regulation Of Dendritic Cell Differentiation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Antigen Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Single Organismal Cell-cell Adhesion Viral Process Response To Stress Intracellular Transport Of Virus Immune Response Antigen Processing And Presentation Of Peptide Antigen Response To Other Organism Response To Biotic Stimulus Negative Regulation Of Calcium Ion Transport T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Cellular Defense Response Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Leukocyte Differentiation Response To Molecule Of Bacterial Origin Positive Regulation Of Immune System Process Negative Regulation Of T Cell Proliferation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Negative Regulation Of Transforming Growth Factor-beta Secretion Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of Gamma-delta T Cell Activation Involved In Immune Response Cytotoxic T Cell Differentiation Negative Regulation Of Interferon-beta Secretion Lymphocyte Activation Regulation Of Defense Response To Virus Regulation Of T Cell Mediated Cytotoxicity Peptide Transport Negative Regulation Of Ion Transport
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