KLRD1 and KLRC3

Number of citations of the paper that reports this interaction (PubMedID 10201920)
0

Data Source:
HPRD (in vivo)

		KLRD1	KLRC3
Description		killer cell lectin like receptor D1	killer cell lectin like receptor C3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex	Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding MHC Class I Protein Complex Binding MHC Class Ib Protein Binding, Via Antigen Binding Groove Carbohydrate Binding HLA-E Specific Inhibitory MHC Class Ib Receptor Activity Protein Antigen Binding	Transmembrane Signaling Receptor Activity Carbohydrate Binding
	Biological Process	Negative Regulation Of T Cell Mediated Cytotoxicity Stimulatory C-type Lectin Receptor Signaling Pathway Natural Killer Cell Mediated Immunity Adaptive Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Regulation Of Natural Killer Cell Activation Innate Immune Response Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity	Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Defense Response Regulation Of Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 signaling DAP12 signaling
Drugs
Diseases
GWAS		Umami taste perception in obesity with metabolic syndrome ( 31005965)	Aspartate aminotransferase levels ( 33547301) Composite immunoglobulin trait (IgA/IgG) ( 28628107) Mean corpuscular volume ( 27863252)
Interacting Genes		6 interacting genes: HLA-B HLA-E HLA-G KLRC1 KLRC2 KLRC3	3 interacting genes: KLRD1 RHOU TYROBP
Entrez ID		3824	3823
HPRD ID		04204	04203
Ensembl ID		ENSG00000134539	ENSG00000205810
Uniprot IDs		F6WZH4 Q13241 Q53ZY6	Q07444
PDB IDs		1B6E 3BDW 3CDG 3CII
Enriched GO Terms of Interacting Partners?		Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Immune Effector Process Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity External Side Of Plasma Membrane Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Innate Immune Response Protection From Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Activation Regulation Of T Cell Mediated Cytotoxicity MHC Class I Protein Complex Positive Regulation Of Immune Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Adaptive Immune Response Positive Regulation Of Innate Immune Response Regulation Of Defense Response Negative Regulation Of Innate Immune Response Regulation Of T Cell Mediated Immunity Regulation Of Immune Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Defense Response Antigen Processing And Presentation Of Endogenous Antigen Lumenal Side Of Endoplasmic Reticulum Membrane Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Defense Response Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Immune Response Regulation Of Adaptive Immune Response Regulation Of Cell Activation Cellular Defense Response Regulation Of Immune System Process ER To Golgi Transport Vesicle Membrane Antigen Processing And Presentation Of Peptide Antigen Negative Regulation Of Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of T Cell Mediated Immunity Innate Immune Response Activating Cell Surface Receptor Signaling Pathway	Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Activation Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Lymphocyte Mediated Immunity HLA-E Specific Inhibitory MHC Class Ib Receptor Activity MHC Class Ib Protein Binding, Via Antigen Binding Groove Leukocyte Mediated Immunity Stimulatory Killer Cell Immunoglobulin-like Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Osteoclast Development Positive Regulation Of Microglial Cell Mediated Cytotoxicity Protein-macromolecule Adaptor Activity Positive Regulation Of Receptor Localization To Synapse Positive Regulation Of Macrophage Fusion Microglial Cell Activation Involved In Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune Effector Process Negative Regulation Of Transforming Growth Factor Beta1 Production Immune Response-regulating Cell Surface Receptor Signaling Pathway MHC Class I Protein Complex Binding Positive Regulation Of Innate Immune Response T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Focal Adhesion Disassembly Protein Antigen Binding Regulation Of Osteoclast Development Tetraspanin-enriched Microdomain Negative Regulation Of T Cell Mediated Cytotoxicity Immune Response-activating Signaling Pathway Neutrophil Activation Involved In Immune Response Negative Regulation Of Long-term Synaptic Potentiation Actin Cytoskeleton Organization Negative Regulation Of Transforming Growth Factor Beta Production Immune Effector Process Immune Response-regulating Signaling Pathway Actin Filament-based Process Activation Of Immune Response Regulation Of Innate Immune Response Negative Regulation Of B Cell Proliferation Endocytosis Positive Regulation Of Defense Response Positive Regulation Of Protein Localization To Cell Surface Macrophage Activation Involved In Immune Response Positive Regulation Of Superoxide Anion Generation Plasma Membrane
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