KLRD1 and KLRC3

Number of citations of the paper that reports this interaction (PMID 8943374)
45

Data Source:
HPRD (in vivo)

		KLRD1	KLRC3
Gene Name		killer cell lectin-like receptor subfamily D, member 1	killer cell lectin-like receptor subfamily C, member 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex	Integral Component Of Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding MHC Class I Protein Complex Binding Carbohydrate Binding Protein Antigen Binding	Transmembrane Signaling Receptor Activity Carbohydrate Binding
	Biological Process	Natural Killer Cell Mediated Immunity Cell Surface Receptor Signaling Pathway Innate Immune Response Regulation Of Immune Response	Cellular Defense Response Signal Transduction
Pathways		DAP12 signaling DAP12 interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: HLA-B HLA-E HLA-G KLRC1 KLRC2 KLRC3	2 interactors: KLRD1 TYROBP
Entrez ID		3824	3823
HPRD ID		04204	04203
Ensembl ID		ENSG00000134539	ENSG00000205810
Uniprot IDs		F6WZH4 Q13241 Q53ZY6	Q07444
PDB IDs		1B6E 3BDW 3CDG 3CII
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Protection From Natural Killer Cell Mediated Cytotoxicity Cellular Defense Response Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Response To Type I Interferon Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Interferon-gamma-mediated Signaling Pathway Regulation Of Dendritic Cell Differentiation Positive Regulation Of Adaptive Immune Response Cellular Response To Interferon-gamma Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Defense Response Response To Interferon-gamma Antigen Processing And Presentation Of Endogenous Antigen Regulation Of Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Innate Immune Response Regulation Of Immune Response Antigen Processing And Presentation Negative Regulation Of Innate Immune Response Negative Regulation Of Immune System Process Cytokine-mediated Signaling Pathway Immune Response Regulation Of Interleukin-12 Production Regulation Of Immune System Process Signal Transduction Signaling Cell Communication Cellular Response To Cytokine Stimulus Positive Regulation Of Immune Response Response To Stress Negative Regulation Of Immune Response Response To Cytokine Cellular Response To Stimulus Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Immune System Process Positive Regulation Of Immune System Process Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Positive Regulation Of Regulatory T Cell Differentiation	Regulation Of Osteoclast Development Neutrophil Activation Involved In Immune Response Macrophage Activation Involved In Immune Response Innate Immune Response Regulation Of Immune Response Neutrophil Activation Natural Killer Cell Mediated Immunity Macrophage Activation Immune Response Regulation Of Immune System Process Defense Response Cellular Defense Response Regulation Of Osteoclast Differentiation Immune System Process Regulation Of Myeloid Leukocyte Differentiation Integrin-mediated Signaling Pathway Leukocyte Activation Involved In Immune Response Regulation Of Myeloid Cell Differentiation
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