KLRD1 and KLRC2

Number of citations of the paper that reports this interaction (PubMedID 10320637)
0

Data Source:
HPRD (in vivo)

		KLRD1	KLRC2
Description		killer cell lectin like receptor D1	killer cell lectin like receptor C2
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex	Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding MHC Class I Protein Complex Binding MHC Class Ib Protein Binding, Via Antigen Binding Groove Carbohydrate Binding HLA-E Specific Inhibitory MHC Class Ib Receptor Activity Protein Antigen Binding	Transmembrane Signaling Receptor Activity Protein Binding MHC Class I Protein Complex Binding Carbohydrate Binding MHC Class Ib Receptor Activity Activating MHC Class Ib Receptor Activity Protein Antigen Binding
	Biological Process	Negative Regulation Of T Cell Mediated Cytotoxicity Stimulatory C-type Lectin Receptor Signaling Pathway Natural Killer Cell Mediated Immunity Adaptive Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Regulation Of Natural Killer Cell Activation Innate Immune Response Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity	Stimulatory C-type Lectin Receptor Signaling Pathway Natural Killer Cell Mediated Immunity Adaptive Immune Response Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Defense Response Signal Transduction Regulation Of Natural Killer Cell Activation Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Degranulation Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 signaling DAP12 signaling	DAP12 interactions DAP12 signaling DAP12 signaling
Drugs
Diseases
GWAS		Umami taste perception in obesity with metabolic syndrome ( 31005965)	Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) Composite immunoglobulin trait (IgA/IgG) ( 28628107) Liver enzyme levels (alanine transaminase) ( 33972514) Lymphocyte count ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		6 interacting genes: HLA-B HLA-E HLA-G KLRC1 KLRC2 KLRC3	3 interacting genes: FBP1 HLA-E KLRD1
Entrez ID		3824	3822
HPRD ID		04204	04202
Ensembl ID		ENSG00000134539	ENSG00000205809
Uniprot IDs		F6WZH4 Q13241 Q53ZY6	P26717
PDB IDs		1B6E 3BDW 3CDG 3CII	2L35
Enriched GO Terms of Interacting Partners?		Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Immune Effector Process Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity External Side Of Plasma Membrane Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Innate Immune Response Protection From Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Activation Regulation Of T Cell Mediated Cytotoxicity MHC Class I Protein Complex Positive Regulation Of Immune Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Adaptive Immune Response Positive Regulation Of Innate Immune Response Regulation Of Defense Response Negative Regulation Of Innate Immune Response Regulation Of T Cell Mediated Immunity Regulation Of Immune Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Defense Response Antigen Processing And Presentation Of Endogenous Antigen Lumenal Side Of Endoplasmic Reticulum Membrane Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Defense Response Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Immune Response Regulation Of Adaptive Immune Response Regulation Of Cell Activation Cellular Defense Response Regulation Of Immune System Process ER To Golgi Transport Vesicle Membrane Antigen Processing And Presentation Of Peptide Antigen Negative Regulation Of Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of T Cell Mediated Immunity Innate Immune Response Activating Cell Surface Receptor Signaling Pathway	Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Activation Regulation Of T Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Positive Regulation Of Antibody-dependent Cellular Cytotoxicity Negative Regulation Of Innate Immune Response Regulation Of Leukocyte Mediated Cytotoxicity Phosphoric Ester Hydrolase Activity Cellular Response To Raffinose Fructose 1,6-bisphosphate 1-phosphatase Activity Regulation Of T Cell Mediated Immunity Positive Regulation Of Lymphocyte Mediated Immunity Lymphocyte Mediated Immunity MHC Class Ib Protein Complex Positive Regulation Of TRAIL Production HLA-E Specific Inhibitory MHC Class Ib Receptor Activity MHC Class Ib Protein Binding, Via Antigen Binding Groove Leukocyte Mediated Immunity Cellular Hypotonic Salinity Response Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Regulation Of TRAIL Production Natural Killer Cell Tolerance Induction Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class Ib Positive Regulation Of Type IIa Hypersensitivity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Lymphocyte Mediated Immunity Cellular Hyperosmotic Salinity Response Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Immune Response Regulation Of Adaptive Immune Response Hyperosmotic Salinity Response Cellular Response To Magnesium Ion Protection From Natural Killer Cell Mediated Cytotoxicity Monosaccharide Binding Positive Regulation Of Hypersensitivity MHC Class I Protein Complex Binding Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Beta-2-microglobulin Binding Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation Natural Killer Cell Lectin-like Receptor Binding Positive Regulation Of Immune Effector Process MHC Class I Protein Complex
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