KLRD1 and KLRC1

Number of citations of the paper that reports this interaction (PubMedID 9034158)
27

Data Source:
HPRD (in vivo)

		KLRD1	KLRC1
Description		killer cell lectin like receptor D1	killer cell lectin like receptor C1
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex	Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding MHC Class I Protein Complex Binding MHC Class Ib Protein Binding, Via Antigen Binding Groove Carbohydrate Binding HLA-E Specific Inhibitory MHC Class Ib Receptor Activity Protein Antigen Binding	Transmembrane Signaling Receptor Activity Protein Binding MHC Class I Protein Complex Binding Carbohydrate Binding MHC Class Ib Receptor Activity Inhibitory MHC Class Ib Receptor Activity HLA-E Specific Inhibitory MHC Class Ib Receptor Activity Protein Antigen Binding
	Biological Process	Negative Regulation Of T Cell Mediated Cytotoxicity Stimulatory C-type Lectin Receptor Signaling Pathway Natural Killer Cell Mediated Immunity Adaptive Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Regulation Of Natural Killer Cell Activation Innate Immune Response Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity	Negative Regulation Of T Cell Mediated Cytotoxicity Stimulatory C-type Lectin Receptor Signaling Pathway Adaptive Immune Response CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Natural Killer Cell Inhibitory Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Natural Killer Cell Activation Regulation Of Natural Killer Cell Mediated Cytotoxicity Innate Immune Response Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 signaling DAP12 signaling	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Umami taste perception in obesity with metabolic syndrome ( 31005965)	Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Granulocyte percentage of myeloid white cells ( 27863252) High light scatter reticulocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Reticulocyte count ( 32888494)
Interacting Genes		6 interacting genes: HLA-B HLA-E HLA-G KLRC1 KLRC2 KLRC3	46 interacting genes: AKT1 ATP6V0B ATP6V0C BMP10 BRICD5 C3orf52 CATSPERH CD151 CD82 CGRRF1 CLDN11 CLEC2D CLEC7A CLRN2 CTXN3 CXCL14 CYB561A3 EMP1 EMP3 ERMP1 GJB2 GJB4 GJB6 GPR61 HLA-E KLRD1 KLRG1 LSMEM2 MAL MALL MS4A13 NKG7 PLP1 PMP22 PTPN11 PTPN6 SFTPC TMEM182 TMEM54 TMPPE TSPO2 UNC93B1 UPK1B VAMP5 VTI1B ZFPL1
Entrez ID		3824	3821
HPRD ID		04204	01192
Ensembl ID		ENSG00000134539	ENSG00000134545
Uniprot IDs		F6WZH4 Q13241 Q53ZY6	P26715
PDB IDs		1B6E 3BDW 3CDG 3CII	2RMX 2YU7 3BDW 3CDG 3CII
Enriched GO Terms of Interacting Partners?		Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Immune Effector Process Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity External Side Of Plasma Membrane Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Innate Immune Response Protection From Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Activation Regulation Of T Cell Mediated Cytotoxicity MHC Class I Protein Complex Positive Regulation Of Immune Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Adaptive Immune Response Positive Regulation Of Innate Immune Response Regulation Of Defense Response Negative Regulation Of Innate Immune Response Regulation Of T Cell Mediated Immunity Regulation Of Immune Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Defense Response Antigen Processing And Presentation Of Endogenous Antigen Lumenal Side Of Endoplasmic Reticulum Membrane Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Defense Response Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Immune Response Regulation Of Adaptive Immune Response Regulation Of Cell Activation Cellular Defense Response Regulation Of Immune System Process ER To Golgi Transport Vesicle Membrane Antigen Processing And Presentation Of Peptide Antigen Negative Regulation Of Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of T Cell Mediated Immunity Innate Immune Response Activating Cell Surface Receptor Signaling Pathway	Membrane Plasma Membrane Gap Junction-mediated Intercellular Transport Bleb Assembly Intercellular Transport Structural Constituent Of Myelin Sheath Natural Killer Cell Mediated Immunity Axon Ensheathment Protein Binding Connexin Complex Gap Junction Channel Activity Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling Gap Junction Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Innate Immune Response-activating Signaling Pathway Myelination Negative Regulation Of Neutrophil Activation Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Gap Junction Assembly Positive Regulation Of Defense Response T Cell Costimulation Activation Of Innate Immune Response Golgi Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V0 Domain Proton-transporting V-type ATPase, V0 Domain Lymphocyte Mediated Immunity Regulation Of Neutrophil Activation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Neutrophil Activation Involved In Immune Response Central Nervous System Myelination Endosomal Lumen Acidification Leukocyte Mediated Immunity Negative Regulation Of Leukocyte Cell-cell Adhesion Defense Response To Symbiont Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Proton-transporting V-type ATPase Complex Defense Response To Other Organism Pattern Recognition Receptor Signaling Pathway Negative Regulation Of T Cell Proliferation Phagocytic Vesicle Membrane T Cell Activation Cell Communication By Electrical Coupling Regulation Of Tumor Necrosis Factor Production Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Peptidyl-tyrosine Dephosphorylation Carbohydrate Binding
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