KLRD1 and KLRC1

Number of citations of the paper that reports this interaction (PMID 8943374)
45

Data Source:
HPRD (in vivo)

		KLRD1	KLRC1
Gene Name		killer cell lectin-like receptor subfamily D, member 1	killer cell lectin-like receptor subfamily C, member 1
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding MHC Class I Protein Complex Binding Carbohydrate Binding Protein Antigen Binding	Transmembrane Signaling Receptor Activity Protein Binding MHC Class I Protein Complex Binding Carbohydrate Binding Protein Antigen Binding
	Biological Process	Natural Killer Cell Mediated Immunity Cell Surface Receptor Signaling Pathway Innate Immune Response Regulation Of Immune Response	Cell Surface Receptor Signaling Pathway Regulation Of Immune Response
Pathways		DAP12 signaling DAP12 interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System Innate Immune System	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: HLA-B HLA-E HLA-G KLRC1 KLRC2 KLRC3	6 interactors: HLA-E KLRD1 MAL PMP22 PTPN11 PTPN6
Entrez ID		3824	3821
HPRD ID		04204	01192
Ensembl ID		ENSG00000134539	ENSG00000134545
Uniprot IDs		F6WZH4 Q13241 Q53ZY6	F5GYZ0 P26715
PDB IDs		1B6E 3BDW 3CDG 3CII	2RMX 2YU7 3BDW 3CDG 3CII
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Protection From Natural Killer Cell Mediated Cytotoxicity Cellular Defense Response Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Response To Type I Interferon Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Interferon-gamma-mediated Signaling Pathway Regulation Of Dendritic Cell Differentiation Positive Regulation Of Adaptive Immune Response Cellular Response To Interferon-gamma Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Defense Response Response To Interferon-gamma Antigen Processing And Presentation Of Endogenous Antigen Regulation Of Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Innate Immune Response Regulation Of Immune Response Antigen Processing And Presentation Negative Regulation Of Innate Immune Response Negative Regulation Of Immune System Process Cytokine-mediated Signaling Pathway Immune Response Regulation Of Interleukin-12 Production Regulation Of Immune System Process Signal Transduction Signaling Cell Communication Cellular Response To Cytokine Stimulus Positive Regulation Of Immune Response Response To Stress Negative Regulation Of Immune Response Response To Cytokine Cellular Response To Stimulus Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Immune System Process Positive Regulation Of Immune System Process Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Positive Regulation Of Regulatory T Cell Differentiation	Abortive Mitotic Cell Cycle Regulation Of Innate Immune Response Innate Immune Response Regulation Of Immune Response Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Interferon-gamma-mediated Signaling Pathway Immune Response Regulation Of Immune System Process Defense Response Cellular Response To Interferon-gamma Megakaryocyte Development Response To Interferon-gamma Regulation Of ERK1 And ERK2 Cascade Platelet Formation Platelet Morphogenesis Regulation Of Interferon-gamma-mediated Signaling Pathway Megakaryocyte Differentiation Regulation Of Response To Interferon-gamma Natural Killer Cell Mediated Immunity Myeloid Cell Differentiation Leukocyte Mediated Immunity Positive Regulation Of Immune System Process Immune System Process Positive Regulation Of Cell Activation Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Lymphocyte Activation Cytokine-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Cell Activation T Cell Costimulation Signaling Cell Communication Cell Surface Receptor Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-15 Production Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Cytotoxic T Cell Differentiation TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Cellular Response To Cytokine Stimulus Regulation Of MAPK Cascade Hemopoiesis Response To Stress Positive Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade
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