KLRC1 and KLRG1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KLRC1	KLRG1
Description		killer cell lectin like receptor C1	killer cell lectin like receptor G1
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex	Plasma Membrane Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding MHC Class I Protein Complex Binding Carbohydrate Binding MHC Class Ib Receptor Activity Inhibitory MHC Class Ib Receptor Activity HLA-E Specific Inhibitory MHC Class Ib Receptor Activity Protein Antigen Binding	Protein Binding Carbohydrate Binding Signaling Receptor Activity
	Biological Process	Negative Regulation Of T Cell Mediated Cytotoxicity Stimulatory C-type Lectin Receptor Signaling Pathway Adaptive Immune Response CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Natural Killer Cell Inhibitory Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Natural Killer Cell Activation Regulation Of Natural Killer Cell Mediated Cytotoxicity Innate Immune Response Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity	Immune System Process Inflammatory Response Cellular Defense Response Cell Surface Receptor Signaling Pathway Innate Immune Response
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Granulocyte percentage of myeloid white cells ( 27863252) High light scatter reticulocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Reticulocyte count ( 32888494)	Appendicular lean mass ( 33097823) Refractive error ( 32231278) Sjögren's syndrome ( 28076899) Type 1 diabetes ( 34012112)
Interacting Genes		46 interacting genes: AKT1 ATP6V0B ATP6V0C BMP10 BRICD5 C3orf52 CATSPERH CD151 CD82 CGRRF1 CLDN11 CLEC2D CLEC7A CLRN2 CTXN3 CXCL14 CYB561A3 EMP1 EMP3 ERMP1 GJB2 GJB4 GJB6 GPR61 HLA-E KLRD1 KLRG1 LSMEM2 MAL MALL MS4A13 NKG7 PLP1 PMP22 PTPN11 PTPN6 SFTPC TMEM182 TMEM54 TMPPE TSPO2 UNC93B1 UPK1B VAMP5 VTI1B ZFPL1	7 interacting genes: ARL13B GPR42 GPX8 KLRC1 LEPROTL1 MRM1 SYNE4
Entrez ID		3821	10219
HPRD ID		01192	16076
Ensembl ID		ENSG00000134545	ENSG00000139187
Uniprot IDs		P26715	Q96E93
PDB IDs		2RMX 2YU7 3BDW 3CDG 3CII	3FF7
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Gap Junction-mediated Intercellular Transport Bleb Assembly Intercellular Transport Structural Constituent Of Myelin Sheath Natural Killer Cell Mediated Immunity Axon Ensheathment Protein Binding Connexin Complex Gap Junction Channel Activity Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling Gap Junction Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Innate Immune Response-activating Signaling Pathway Myelination Negative Regulation Of Neutrophil Activation Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Gap Junction Assembly Positive Regulation Of Defense Response T Cell Costimulation Activation Of Innate Immune Response Golgi Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V0 Domain Proton-transporting V-type ATPase, V0 Domain Lymphocyte Mediated Immunity Regulation Of Neutrophil Activation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Neutrophil Activation Involved In Immune Response Central Nervous System Myelination Endosomal Lumen Acidification Leukocyte Mediated Immunity Negative Regulation Of Leukocyte Cell-cell Adhesion Defense Response To Symbiont Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Proton-transporting V-type ATPase Complex Defense Response To Other Organism Pattern Recognition Receptor Signaling Pathway Negative Regulation Of T Cell Proliferation Phagocytic Vesicle Membrane T Cell Activation Cell Communication By Electrical Coupling Regulation Of Tumor Necrosis Factor Production Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Peptidyl-tyrosine Dephosphorylation Carbohydrate Binding	Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Establishment Of Epithelial Cell Apical/basal Polarity Establishment Of Epithelial Cell Polarity Telencephalon Cell Migration Establishment Or Maintenance Of Apical/basal Cell Polarity Forebrain Cell Migration Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation Inhibitory MHC Class Ib Receptor Activity Aortic Valve Formation Establishment Of Cell Polarity Positive Regulation Of Vascular Associated Smooth Muscle Contraction Endothelial Tube Lumen Extension Skeletal Muscle Satellite Cell Migration HLA-E Specific Inhibitory MHC Class Ib Receptor Activity RRNA (guanosine-2'-O-)-methyltransferase Activity Beta Selection Epithelial Tube Morphogenesis Natural Killer Cell Inhibitory Signaling Pathway CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation RRNA (guanine) Methyltransferase Activity RRNA 2'-O-methylation Receptor Localization To Non-motile Cilium Bone Trabecula Morphogenesis Formation Of Radial Glial Scaffolds Apolipoprotein A-I-mediated Signaling Pathway Establishment Or Maintenance Of Cell Polarity Roundabout Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Endothelin Forebrain Radial Glial Cell Differentiation MHC Class Ib Receptor Activity Positive Regulation Of Lipase Activity Cleavage Furrow Formation Cell Morphogenesis Apical Junction Assembly Negative Regulation Of Oxidative Phosphorylation Regulation Of Modification Of Postsynaptic Actin Cytoskeleton MHC Class I Protein Complex Binding Protein Localization To Ciliary Membrane Interneuron Migration From The Subpallium To The Cortex Neural Tube Patterning Negative Regulation Of Cell Size Ossification Involved In Bone Maturation Negative Regulation Of Cellular Respiration Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Protein Antigen Binding
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