KLRC1 and EMP3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KLRC1	EMP3
Description		killer cell lectin like receptor C1	epithelial membrane protein 3 (MAM blood group)
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex	Plasma Membrane Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding MHC Class I Protein Complex Binding Carbohydrate Binding MHC Class Ib Receptor Activity Inhibitory MHC Class Ib Receptor Activity HLA-E Specific Inhibitory MHC Class Ib Receptor Activity Protein Antigen Binding	Protein Binding
	Biological Process	Negative Regulation Of T Cell Mediated Cytotoxicity Stimulatory C-type Lectin Receptor Signaling Pathway Adaptive Immune Response CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Natural Killer Cell Inhibitory Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Natural Killer Cell Activation Regulation Of Natural Killer Cell Mediated Cytotoxicity Innate Immune Response Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity	Apoptotic Process Bleb Assembly
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Granulocyte percentage of myeloid white cells ( 27863252) High light scatter reticulocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Reticulocyte count ( 32888494)
Interacting Genes		46 interacting genes: AKT1 ATP6V0B ATP6V0C BMP10 BRICD5 C3orf52 CATSPERH CD151 CD82 CGRRF1 CLDN11 CLEC2D CLEC7A CLRN2 CTXN3 CXCL14 CYB561A3 EMP1 EMP3 ERMP1 GJB2 GJB4 GJB6 GPR61 HLA-E KLRD1 KLRG1 LSMEM2 MAL MALL MS4A13 NKG7 PLP1 PMP22 PTPN11 PTPN6 SFTPC TMEM182 TMEM54 TMPPE TSPO2 UNC93B1 UPK1B VAMP5 VTI1B ZFPL1	43 interacting genes: AQP6 CD79A CLDN2 CLDN7 CREB3L1 CREM EDA ELOVL7 ERGIC3 FAM210B FNDC9 GJA5 GJB1 GPA33 GPR61 IFNGR2 IL3RA KIR3DL3 KLRC1 LDLRAD1 LEUTX LHFPL5 LRRC4C LYVE1 MR1 MS4A3 MUC1 OPRM1 P2RX7 PLEKHB2 RMDN3 SAR1A SECTM1 SIGLECL1 SLAMF8 SLC30A2 SLC35H1 SMIM3 SPACA1 TM4SF18 TMX2 TSPAN12 VSIG1
Entrez ID		3821	2014
HPRD ID		01192	18514
Ensembl ID		ENSG00000134545	ENSG00000142227
Uniprot IDs		P26715	P54852
PDB IDs		2RMX 2YU7 3BDW 3CDG 3CII
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Gap Junction-mediated Intercellular Transport Bleb Assembly Intercellular Transport Structural Constituent Of Myelin Sheath Natural Killer Cell Mediated Immunity Axon Ensheathment Protein Binding Connexin Complex Gap Junction Channel Activity Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling Gap Junction Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Innate Immune Response-activating Signaling Pathway Myelination Negative Regulation Of Neutrophil Activation Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Gap Junction Assembly Positive Regulation Of Defense Response T Cell Costimulation Activation Of Innate Immune Response Golgi Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V0 Domain Proton-transporting V-type ATPase, V0 Domain Lymphocyte Mediated Immunity Regulation Of Neutrophil Activation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Neutrophil Activation Involved In Immune Response Central Nervous System Myelination Endosomal Lumen Acidification Leukocyte Mediated Immunity Negative Regulation Of Leukocyte Cell-cell Adhesion Defense Response To Symbiont Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Proton-transporting V-type ATPase Complex Defense Response To Other Organism Pattern Recognition Receptor Signaling Pathway Negative Regulation Of T Cell Proliferation Phagocytic Vesicle Membrane T Cell Activation Cell Communication By Electrical Coupling Regulation Of Tumor Necrosis Factor Production Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Peptidyl-tyrosine Dephosphorylation Carbohydrate Binding	Membrane Protein Binding Plasma Membrane Gap Junction Assembly Regulation Of T Cell Mediated Immunity Regulation Of T Cell Mediated Cytotoxicity Cell-cell Junction Assembly
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