HLA-DPA1 and CD4

Number of citations of the paper that reports this interaction (PubMedID 12899833)
0

Data Source:
HPRD (in vivo)

		HLA-DPA1	CD4
Description		major histocompatibility complex, class II, DP alpha 1	CD4 molecule
Image
GO Annotations	Cellular Component	Golgi Membrane Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Cell Surface Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Lumenal Side Of Endoplasmic Reticulum Membrane	Early Endosome Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Clathrin-coated Endocytic Vesicle Membrane T Cell Receptor Complex Membrane Raft
	Molecular Function	Protein Binding MHC Class II Protein Complex Binding MHC Class II Receptor Activity Peptide Antigen Binding	Virus Receptor Activity Transmembrane Signaling Receptor Activity Signaling Receptor Binding Extracellular Matrix Structural Constituent Protein Binding Zinc Ion Binding Lipid Binding Coreceptor Activity Immunoglobulin Binding Enzyme Binding Protein Kinase Binding MHC Class II Protein Complex Binding Signaling Receptor Activity Interleukin-16 Binding Interleukin-16 Receptor Activity MHC Class II Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Tyrosine Kinase Binding
	Biological Process	Adaptive Immune Response Immune System Process Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Type II Interferon Production Positive Regulation Of T Cell Proliferation Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation Cellular Response To Type II Interferon	Positive Regulation Of Protein Phosphorylation Adaptive Immune Response Immune System Process Positive Regulation Of Immune System Process Immune Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Calcium Ion Transport Into Cytosol Calcium-mediated Signaling T Cell Differentiation Macrophage Differentiation Response To Estradiol Maintenance Of Protein Location In Cell Positive Regulation Of Interleukin-2 Production Response To Vitamin D Positive Regulation Of Kinase Activity Helper T Cell Enhancement Of Adaptive Immune Response Interleukin-15-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation T Cell Activation Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade T Cell Selection Response To Ethanol Positive Regulation Of Monocyte Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of DNA-templated Transcription Positive Regulation Of Viral Entry Into Host Cell Symbiont Entry Into Host Cell Defense Response To Gram-negative Bacterium Positive Regulation Of Calcium-mediated Signaling Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Positive Regulation Of Multicellular Organismal Process Regulation Of Calcium Ion Transport Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Response To Methamphetamine Hydrochloride Cellular Response To Ionomycin
Pathways		Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation Co-inhibition by PD-1 Interferon gamma signaling	Alpha-defensins Nef Mediated CD4 Down-regulation Binding and entry of HIV virion Vpu mediated degradation of CD4 Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules Co-inhibition by PD-1 Other interleukin signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Antithymocyte immunoglobulin (rabbit) Clenoliximab Ibalizumab
Diseases		Dilated cardiomyopathy (DCM)
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757) Asthma ( 31619474 30929738) Asthma (childhood onset) ( 30929738) Autism spectrum disorder or schizophrenia ( 28540026) Chronic hepatitis B infection ( 25802187) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil count ( 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Hepatitis B ( 21750111) Hepatitis B (viral clearance) ( 22737229) Hip circumference adjusted for BMI ( 34021172) IgA nephropathy ( 25305756) Keratinocyte cancer (MTAG) ( 31174203) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Lymphocyte percentage of white cells ( 32888494) Monocyte percentage of white cells ( 32888494) Mortality in sepsis ( 27639821) Myositis ( 26291516) Nephropathy ( 21399633) Persistent hepatitis B virus infection ( 33736632) Pulmonary arterial hypertension ( 30527956) Response to hepatitis B vaccine ( 29534301) Sjögren's syndrome ( 24097066) Systemic lupus erythematosus ( 32771030) Systemic sclerosis ( 21779181) Takayasu arteritis ( 25604533) Type 1 diabetes (age at diagnosis) ( 33179336)	Bone mineral density (hip) ( 30172743) Response to Vitamin E supplementation ( 22437554)
Interacting Genes		6 interacting genes: CD4 CD74 CNMD HLA-DPB1 TMEM50A TMEM50B	39 interacting genes: ABCB1 ADORA2A ADRB2 CCR5 CD2 CD28 CD38 CD44 CD5 CD53 CD82 CTSD CXCL12 CXCR4 DPP4 FCGR3A HLA-DPA1 HLA-DQA2 HLA-DQB1 IL16 IL2RA INPPL1 KCNAB2 LAT LCK LGALS1 MAPK14 MARCHF4 PI4KA PIK3R1 PIP PTPRC SELL SIVA1 SPG21 TFRC TNFRSF10A UBL7 UNC119
Entrez ID		3113	920
HPRD ID		00835	01740
Ensembl ID		ENSG00000231389	ENSG00000010610
Uniprot IDs		P20036 X5CKE2	A0A4Y5UGE4 B0AZV7 B4DT49 P01730
PDB IDs		3LQZ 4P4K 4P4R 4P57 4P5K 4P5M 7T2A 7T2B 7T2C 7T2D	1CDH 1CDI 1CDJ 1CDU 1CDY 1G9M 1G9N 1GC1 1JL4 1Q68 1RZJ 1RZK 1WBR 1WIO 1WIP 1WIQ 2B4C 2JKR 2JKT 2KLU 2NXY 2NXZ 2NY0 2NY1 2NY2 2NY3 2NY4 2NY5 2NY6 2QAD 3B71 3CD4 3J70 3JCB 3JCC 3JWD 3JWO 3LQA 3O2D 3S4S 3S5L 3T0E 4H8W 4JM2 4P9H 4Q6I 4R2G 4R4H 4RQS 5A7X 5A8H 5CAY 5THR 5U1F 5VN3 6CM3 6EDU 6L1Y 6MEO 6MET 6OPN 6OPO 6OPP 6OPQ 6QH6 6QH7 6U0L 6U0N 6URI 6X5B 6X5C 7T0O 7T0R 7TXD 8D5C 8FYI 8FYJ 8W90 8Z7N
Enriched GO Terms of Interacting Partners?		MHC Class II Protein Complex Binding Clathrin-coated Endocytic Vesicle Membrane MHC Class II Protein Binding Positive Regulation Of Monocyte Differentiation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Mononuclear Cell Proliferation MHC Class II Protein Complex Regulation Of Monocyte Differentiation Positive Regulation Of Leukocyte Proliferation Regulation Of Viral Entry Into Host Cell Positive Regulation Of Viral Life Cycle Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway T Cell Selection Lumenal Side Of Endoplasmic Reticulum Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Regulation Of Mononuclear Cell Proliferation Late Endosome To Vacuole Transport Positive Regulation Of T Cell Activation Endosome Transport Via Multivesicular Body Sorting Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Leukocyte Proliferation Antigen Processing And Presentation Of Exogenous Peptide Antigen Adaptive Immune Response Multivesicular Body Sorting Pathway Antigen Processing And Presentation Of Exogenous Antigen Transport Vesicle Membrane Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation ER To Golgi Transport Vesicle Membrane Endoplasmic Reticulum Membrane Positive Regulation Of Viral Process Positive Regulation Of Myeloid Leukocyte Differentiation Antigen Processing And Presentation Of Peptide Antigen Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Endocytic Vesicle Membrane Interleukin-16 Binding Interleukin-16 Receptor Activity Helper T Cell Enhancement Of Adaptive Immune Response MHC Class II Protein Binding, Via Antigen Binding Groove NOS2-CD74 Complex Macrophage Migration Inhibitory Factor Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Cytokine Production Regulation Of Cell-cell Adhesion Antigen Processing And Presentation	Immune System Process Regulation Of Immune System Process Positive Regulation Of Immune System Process Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Regulation Of Cell Adhesion Positive Regulation Of Leukocyte Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell-cell Adhesion Regulation Of Immune Response Positive Regulation Of T Cell Activation Positive Regulation Of Cell Adhesion Antigen Receptor-mediated Signaling Pathway Plasma Membrane Cell Activation External Side Of Plasma Membrane Lymphocyte Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Surface Signal Transduction Leukocyte Activation Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Positive Regulation Of Immune Response T Cell Activation Immune Response-regulating Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation T Cell Costimulation Immune Response-activating Signaling Pathway Positive Regulation Of Leukocyte Proliferation Defense Response Immune Response Activation Of Immune Response Membrane Raft Distribution Clathrin-coated Endocytic Vesicle Membrane Apoptotic Signaling Pathway Membrane Raft Localization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Leukocyte Migration Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II MHC Class II Receptor Activity
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