HLA-DPA1 and TMEM50B

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		HLA-DPA1	TMEM50B
Name		major histocompatibility complex, class II, DP alpha 1	transmembrane protein 50B
Structure			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Cell Surface Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Lumenal Side Of Endoplasmic Reticulum Membrane	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane
	Molecular Function	Protein Binding MHC Class II Protein Complex Binding MHC Class II Receptor Activity Peptide Antigen Binding	Protein Binding
	Biological Process	Adaptive Immune Response Immune System Process Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Type II Interferon Production Positive Regulation Of T Cell Proliferation Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation Cellular Response To Type II Interferon	Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway
Pathways		Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation Co-inhibition by PD-1 Interferon gamma signaling	None
Diseases		Dilated cardiomyopathy (DCM)	None
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757 ) Asthma ( 31619474 30929738 ) Asthma (childhood onset) ( 30929738 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Chronic hepatitis B infection ( 25802187 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Eosinophil count ( 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 32888494 27863252 ) Hepatitis B ( 21750111 ) Hepatitis B (viral clearance) ( 22737229 ) Hip circumference adjusted for BMI ( 34021172 ) IgA nephropathy ( 25305756 ) Keratinocyte cancer (MTAG) ( 31174203 ) Lung cancer ( 28604730 ) Lung cancer in ever smokers ( 28604730 ) Lymphocyte percentage of white cells ( 32888494 ) Monocyte percentage of white cells ( 32888494 ) Mortality in sepsis ( 27639821 ) Myositis ( 26291516 ) Nephropathy ( 21399633 ) Persistent hepatitis B virus infection ( 33736632 ) Pulmonary arterial hypertension ( 30527956 ) Response to hepatitis B vaccine ( 29534301 ) Sjögren's syndrome ( 24097066 ) Systemic lupus erythematosus ( 32771030 ) Systemic sclerosis ( 21779181 ) Takayasu arteritis ( 25604533 ) Type 1 diabetes (age at diagnosis) ( 33179336 )	Crohn's disease ( 23128233 ) Educational attainment ( 25201988 )
Interacting Genes		6 interacting genes: CD4 CD74 CNMD HLA-DPB1 TMEM50A TMEM50B	21 interacting genes: AMIGO1 BCL2L1 CLRN1 CREB3L1 EDA FAM209A FXYD3 GPR152 GPX8 HLA-DPA1 LEPROTL1 LHFPL5 NCR1 SCN3B SLC10A6 SLC16A13 SLC35H1 TMEM14B TMEM52B TMEM88 TMX2
Entrez ID		3113	757
HPRD ID		00835	10747
Ensembl ID		ENSG00000231389	ENSG00000142188
Uniprot IDs		P20036 X5CKE2	F8WDH1 P56557 Q2V8N0
PDB IDs		3LQZ 4P4K 4P4R 4P57 4P5K 4P5M 7T2A 7T2B 7T2C 7T2D	Not available
GO Terms Enriched among Interactors		MHC Class II Protein Complex Binding Clathrin-coated Endocytic Vesicle Membrane MHC Class II Protein Binding Positive Regulation Of Monocyte Differentiation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Mononuclear Cell Proliferation MHC Class II Protein Complex Regulation Of Monocyte Differentiation Positive Regulation Of Leukocyte Proliferation Regulation Of Viral Entry Into Host Cell Positive Regulation Of Viral Life Cycle Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway T Cell Selection Lumenal Side Of Endoplasmic Reticulum Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Regulation Of Mononuclear Cell Proliferation Late Endosome To Vacuole Transport Positive Regulation Of T Cell Activation Endosome Transport Via Multivesicular Body Sorting Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Leukocyte Proliferation Antigen Processing And Presentation Of Exogenous Peptide Antigen Adaptive Immune Response Multivesicular Body Sorting Pathway Antigen Processing And Presentation Of Exogenous Antigen Transport Vesicle Membrane Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation ER To Golgi Transport Vesicle Membrane Endoplasmic Reticulum Membrane Positive Regulation Of Viral Process Positive Regulation Of Myeloid Leukocyte Differentiation Antigen Processing And Presentation Of Peptide Antigen Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Endocytic Vesicle Membrane Interleukin-16 Binding Interleukin-16 Receptor Activity Helper T Cell Enhancement Of Adaptive Immune Response MHC Class II Protein Binding, Via Antigen Binding Groove NOS2-CD74 Complex Macrophage Migration Inhibitory Factor Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Cytokine Production Regulation Of Cell-cell Adhesion Antigen Processing And Presentation	Membrane Mitochondrial Membrane