HLA-DPA1

Gene Name		major histocompatibility complex, class II, DP alpha 1
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Gene Ontology Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endosome Membrane ER To Golgi Transport Vesicle Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	MHC Class II Receptor Activity Peptide Antigen Binding
	Biological Process	Immune Response Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Costimulation Positive Regulation Of Interferon-gamma Production Positive Regulation Of T Cell Proliferation T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Interferon-gamma-mediated Signaling Pathway Cellular Response To Interferon-gamma
Pathways		Generation of second messenger molecules Downstream TCR signaling Costimulation by the CD28 family Translocation of ZAP-70 to Immunological synapse Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling TCR signaling MHC class II antigen presentation PD-1 signaling Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs
Diseases
GWAS		Hepatitis B ( 21750111) Hepatitis B (viral clearance) ( 22737229) Nephropathy ( 21399633) Systemic sclerosis ( 21779181)
Protein-protein Interactions		3 interactors: CD4 CD74 HLA-DPB1
Entrez ID		3113
HPRD ID		00835
Ensembl ID		ENSG00000231389
Uniprot IDs		P20036
PDB IDs		3LQZ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Cytokine Production Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Cell Activation T Cell Selection Regulation Of Cytokine Production Regulation Of Cell Adhesion Positive Regulation Of Immune Response T Cell Costimulation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Regulation Of Immune Response Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of Immune System Process T Cell Receptor Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Antigen Receptor-mediated Signaling Pathway Induction By Virus Of Host Cell-cell Fusion Macrophage Migration Inhibitory Factor Signaling Pathway Protein Palmitoleylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation T Cell Differentiation Immune Response Regulation Of Immune System Process Defense Response Regulation Of Peptidyl-tyrosine Phosphorylation Antigen Processing And Presentation Of Peptide Antigen Lymphocyte Differentiation T Cell Aggregation T Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Lymphocyte Aggregation Antigen Processing And Presentation Leukocyte Aggregation Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Mature B Cell Apoptotic Process Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Leukocyte Differentiation Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Regulation Of Cellular Amino Acid Metabolic Process Lymphocyte Activation
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