ZBTB48 and UPF2

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)

		ZBTB48	UPF2
Description		zinc finger and BTB domain containing 48	UPF2 regulator of nonsense mediated mRNA decay
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Chromosome	Nucleus Cytoplasm Cytosol Exon-exon Junction Complex Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Double-stranded Telomeric DNA Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding	RNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Via Telomere Lengthening Positive Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Liver Development MRNA Export From Nucleus Animal Organ Regeneration
Pathways			Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Body size at age 10 ( 32376654)	Diverticular disease ( 30177863)
Interacting Genes		35 interacting genes: C11orf58 CDK2AP2 CDKN1A CEP70 DVL2 DVL3 EP300 GPATCH2L ILK KRTAP1-1 KRTAP10-5 KRTAP10-7 L3MBTL2 LLCFC1 MAP1LC3A MCC NME7 PNRC2 RGS2 RNF10 SPANXN2 THAP1 TNFRSF14 TRIM41 TSPYL2 UPF2 WDR5 ZBTB26 ZBTB6 ZBTB7A ZBTB8A ZBTB9 ZNF317 ZNF408 ZNF837	76 interacting genes: ABCF2 AGPAT1 AKTIP ART4 ATP1B3 BLM CALR CENPU CIZ1 COMTD1 CYBA DCP1B DCP2 DPF2 E4F1 EIF1 EIF4A1 EIF4G1 ENO1 EXOSC1 EXOSC10 EXOSC4 EXOSC6 EXOSC8 GADD45GIP1 HBZ HMGA1 HS3ST3A1 HSF2BP ITGB1 KRT18 LDHA LSM1 MAP1A MAP1LC3B MIF MRPL40 MTERF3 MTREX MYB NDUFA7 NOB1 NOMO1 NOP53 PHB2 PITX1 PUF60 RNPS1 RPL13 RPL5 RPL8 RPS15 RPS25 RPS6 RPS7 RRP7A RSRC2 SERBP1 SERF2 SMG1 SUMO3 TK1 TNNI2 TOP3B TUBB2A TYMS UPF1 UPF3B WNK1 XRN1 XRN2 ZBTB48 ZFP36 ZGPAT ZNF408 ZNF44
Entrez ID		3104	26019
HPRD ID		01316	10405
Ensembl ID		ENSG00000204859	ENSG00000151461
Uniprot IDs		A8K291 B2R702 P10074	Q9HAU5
PDB IDs		3B84 5YJ3	1UW4 2WJV 4CEK 4CEM 7NWU 7QG6
Enriched GO Terms of Interacting Partners?		Zinc Ion Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of DNA-templated Transcription Positive Regulation Of Neuron Projection Arborization Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Neuron Projection Arborization	RNA Binding Nuclear-transcribed MRNA Catabolic Process RNA Catabolic Process MRNA Catabolic Process Nucleobase-containing Compound Catabolic Process RRNA Metabolic Process RRNA Processing Nucleic Acid Metabolic Process Exosome (RNase Complex) Nucleus Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process RNA Metabolic Process Histone MRNA Catabolic Process Nuclear Exosome (RNase Complex) Negative Regulation Of Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nucleolar Exosome (RNase Complex) Negative Regulation Of Macromolecule Biosynthetic Process Nuclear MRNA Surveillance Ribosome Histone MRNA Metabolic Process Negative Regulation Of Biosynthetic Process Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Regulation Of Gene Expression Ribonucleoprotein Complex Biogenesis Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Gene Expression RNA Processing Ribosomal Small Subunit Biogenesis Translation Regulation Of Macromolecule Metabolic Process Ribonucleoprotein Complex Nucleolus Nucleic Acid Binding Cytosolic Ribosome Positive Regulation Of MRNA Cis Splicing, Via Spliceosome 5'-3' RNA Exonuclease Activity Regulation Of Metabolic Process Nuclear RNA Surveillance RRNA Catabolic Process RNA Surveillance DNA Metabolic Process Cytosol Cytoplasmic Translation Negative Regulation Of Protein Metabolic Process Macromolecule Catabolic Process
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