SACS and TSC22D4

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SACS	TSC22D4
Gene Name		sacsin molecular chaperone	TSC22 domain family, member 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Axon Dendrite Cell Body Fiber	Nucleus Cytoplasm
	Molecular Function	Hsp70 Protein Binding Chaperone Binding Proteasome Binding	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Protein Folding Negative Regulation Of Inclusion Body Assembly	Transcription, DNA-templated Response To Osmotic Stress Negative Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS		Hypothyroidism ( 22493691) Protein quantitative trait loci ( 18464913) Type 2 diabetes ( 23300278)
Protein-Protein Interactions		5 interactors: ACTN4 PICK1 TSC22D4 UBE3A ZNRD1	53 interactors: ABLIM1 AES AIFM1 APIP BLZF1 BZRAP1 CCDC146 CCDC33 CCDC42 CCNK CDC23 CDK5R1 CKS2 CLU ENKD1 FRMD6 FXR2 GNB2L1 GOLGA2 GORASP2 KEAP1 KPNA2 KRT40 LBP LMO2 LNX1 LRP2BP MAD2L1 MTHFS MYLIP NIF3L1 NOC4L NRBP1 NRBP2 PCBP1 PIH1D1 PIN1 POLR1C PPL PRKAA1 PRKAA2 PRNP PSMA1 SACS SAT1 SMAD3 SYT17 TEX11 TSC22D1 UBLCP1 ZBTB24 ZMYND10 ZNF580
Entrez ID		26278	81628
HPRD ID		05135	18231
Ensembl ID		ENSG00000151835	ENSG00000166925
Uniprot IDs		Q9NZJ4	A8MWR6 Q9Y3Q8
PDB IDs		1IUR 3O10
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Endocytosis Sperm Entry Protein Localization To Tight Junction Positive Regulation Of Pinocytosis Regulation Of Endocytosis Intracellular Receptor Signaling Pathway Regulation Of Gene Expression, Epigenetic Positive Regulation Of Sodium:proton Antiporter Activity Response To Abiotic Stimulus Regulation Of Sodium:proton Antiporter Activity Peroxisome Proliferator Activated Receptor Signaling Pathway Protein Localization To Cell Junction DNA Methylation Involved In Embryo Development Dendritic Spine Maintenance Vesicle-mediated Transport Regulation Of Vesicle-mediated Transport Neuronal Ion Channel Clustering Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Proton Transport Negative Regulation Of Actin Nucleation Regulation Of Metabolic Process Positive Regulation Of Sodium Ion Transmembrane Transport Long Term Synaptic Depression Positive Regulation Of Receptor Internalization Prostate Gland Growth Regulation Of Arp2/3 Complex-mediated Actin Nucleation Dendritic Spine Organization DNA Methylation Involved In Gamete Generation Actin Crosslink Formation Regulation Of Actin Nucleation Cellular Response To Glucose Starvation Monoamine Transport Termination Of RNA Polymerase I Transcription Cellular Component Maintenance Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Retinoic Acid Receptor Signaling Pathway Regulation Of Sodium Ion Transmembrane Transporter Activity Neuron Maturation Regulation Of Receptor Internalization Transcription From RNA Polymerase I Promoter Regulation Of Gene Expression Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Sodium Ion Transport Retrograde Vesicle-mediated Transport, Golgi To ER Positive Regulation Of Receptor-mediated Endocytosis Protein K48-linked Ubiquitination Androgen Receptor Signaling Pathway Positive Regulation Of Transport	Cell Cycle Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Cell Cycle Negative Regulation Of Cell Death Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Proteolysis Negative Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Cellular Process Cell Cycle Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Ubiquitination Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cytokine Production Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Ubiquitination Negative Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Cell Death Regulation Of Protein Phosphorylation Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cell Cycle Arrest Negative Regulation Of Signal Transduction Nitrogen Compound Metabolic Process Regulation Of Energy Homeostasis Negative Regulation Of Protein Metabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Glycolytic Process Cellular Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		agglutination air birds broth chickens gallisepticum mycoplasma p120 p200 p22 p24 p26 p28 p31 p33 p35 p40 p45 p50 p56 p60 p64 p72 p80 p98 plate spa synoviae	ablation cachectic cachexia clone deprivation diminished hepatic hepatocytes hypertriglyceridemia hypo hypobetalipoproteinemia lipids lipogenic livers mammals metabolic mimicking output proper rationale rescued secretion storage transforming triggers vldl wasting
Tagcloud (Difference) ?		agglutination air birds broth chickens gallisepticum mycoplasma p120 p200 p22 p24 p26 p28 p31 p33 p35 p40 p45 p50 p56 p60 p64 p72 p80 p98 plate spa synoviae	ablation cachectic cachexia clone deprivation diminished hepatic hepatocytes hypertriglyceridemia hypo hypobetalipoproteinemia lipids lipogenic livers mammals metabolic mimicking output proper rationale rescued secretion storage transforming triggers vldl wasting
Tagcloud (Intersection) ?