SACS and ZNRD1

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SACS	ZNRD1
Gene Name		sacsin molecular chaperone	zinc ribbon domain containing 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Axon Dendrite Cell Body Fiber	Nucleoplasm DNA-directed RNA Polymerase I Complex
	Molecular Function	Hsp70 Protein Binding Chaperone Binding Proteasome Binding	RNA Polymerase I Activity Nucleic Acid Binding Zinc Ion Binding
	Biological Process	Protein Folding Negative Regulation Of Inclusion Body Assembly	Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Gene Expression Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic
Pathways			NoRC negatively regulates rRNA expression RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Escape RNA Polymerase I Promoter Clearance Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression
Drugs
Diseases
GWAS		Hypothyroidism ( 22493691) Protein quantitative trait loci ( 18464913) Type 2 diabetes ( 23300278)	AIDS progression ( 19115949) HIV-1 control ( 20041166)
Protein-Protein Interactions		5 interactors: ACTN4 PICK1 TSC22D4 UBE3A ZNRD1	15 interactors: APOA1 ATXN2 CIC DUSP1 FHL3 GFI1B GPR20 HAX1 IL15 IVNS1ABP NONO SACS SERPINA3 UBE2I ZNF593
Entrez ID		26278	30834
HPRD ID		05135	09601
Ensembl ID		ENSG00000151835	ENSG00000066379
Uniprot IDs		Q9NZJ4	Q2L6J2 Q9P1U0
PDB IDs		1IUR 3O10
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Endocytosis Sperm Entry Protein Localization To Tight Junction Positive Regulation Of Pinocytosis Regulation Of Endocytosis Intracellular Receptor Signaling Pathway Regulation Of Gene Expression, Epigenetic Positive Regulation Of Sodium:proton Antiporter Activity Response To Abiotic Stimulus Regulation Of Sodium:proton Antiporter Activity Peroxisome Proliferator Activated Receptor Signaling Pathway Protein Localization To Cell Junction DNA Methylation Involved In Embryo Development Dendritic Spine Maintenance Vesicle-mediated Transport Regulation Of Vesicle-mediated Transport Neuronal Ion Channel Clustering Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Proton Transport Negative Regulation Of Actin Nucleation Regulation Of Metabolic Process Positive Regulation Of Sodium Ion Transmembrane Transport Long Term Synaptic Depression Positive Regulation Of Receptor Internalization Prostate Gland Growth Regulation Of Arp2/3 Complex-mediated Actin Nucleation Dendritic Spine Organization DNA Methylation Involved In Gamete Generation Actin Crosslink Formation Regulation Of Actin Nucleation Cellular Response To Glucose Starvation Monoamine Transport Termination Of RNA Polymerase I Transcription Cellular Component Maintenance Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Retinoic Acid Receptor Signaling Pathway Regulation Of Sodium Ion Transmembrane Transporter Activity Neuron Maturation Regulation Of Receptor Internalization Transcription From RNA Polymerase I Promoter Regulation Of Gene Expression Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Sodium Ion Transport Retrograde Vesicle-mediated Transport, Golgi To ER Positive Regulation Of Receptor-mediated Endocytosis Protein K48-linked Ubiquitination Androgen Receptor Signaling Pathway Positive Regulation Of Transport	Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Intracellular Signal Transduction Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Process Extrathymic T Cell Selection Negative Regulation Of Cell Adhesion Molecule Production Positive Regulation Of SUMO Transferase Activity Regulation Of Signal Transduction Negative Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Interleukin-1 Beta Secretion Regulation Of Signaling Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Cholesterol Import NK T Cell Proliferation Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Interleukin-1 Secretion Alpha-beta T Cell Proliferation Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Regulation Of Protein Phosphorylation Skeletal Muscle Atrophy High-density Lipoprotein Particle Clearance Negative Regulation Of Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Natural Killer Cell Proliferation Striated Muscle Atrophy Protein Oxidation Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Gene Expression Regulation Of Natural Killer Cell Proliferation Muscle Atrophy Negative Regulation Of Cytokine Secretion Involved In Immune Response Negative Regulation Of Heterotypic Cell-cell Adhesion High-density Lipoprotein Particle Assembly Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Signaling Regulation Of Cellular Component Organization Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Tagcloud ?		agglutination air birds broth chickens gallisepticum mycoplasma p120 p200 p22 p24 p26 p28 p31 p33 p35 p40 p45 p50 p56 p60 p64 p72 p80 p98 plate spa synoviae	acceleration angiogenesis arrest block cdk2 cdk4 cip1 controlling cytostatic densities dephosphorylation differentially fragmentary gastric instability kip1 microarray microvessel mkn28 p27 pivotal prb precise ribbon sense skp2 suppressed waf1 zinc
Tagcloud (Difference) ?		agglutination air birds broth chickens gallisepticum mycoplasma p120 p200 p22 p24 p26 p28 p31 p33 p35 p40 p45 p50 p56 p60 p64 p72 p80 p98 plate spa synoviae	acceleration angiogenesis arrest block cdk2 cdk4 cip1 controlling cytostatic densities dephosphorylation differentially fragmentary gastric instability kip1 microarray microvessel mkn28 p27 pivotal prb precise ribbon sense skp2 suppressed waf1 zinc
Tagcloud (Intersection) ?