SACS

Gene Name		sacsin molecular chaperone
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Axon Dendrite Cell Body Fiber
	Molecular Function	Hsp70 Protein Binding Chaperone Binding Proteasome Binding
	Biological Process	Protein Folding Negative Regulation Of Inclusion Body Assembly
Pathways
Drugs
Diseases
GWAS		Hypothyroidism ( 22493691) Protein quantitative trait loci ( 18464913) Type 2 diabetes ( 23300278)
Protein-protein Interactions		5 interactors: ACTN4 PICK1 TSC22D4 UBE3A ZNRD1
Entrez ID		26278
HPRD ID		05135
Ensembl ID		ENSG00000151835
Uniprot IDs		Q9NZJ4
PDB IDs		1IUR 3O10
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Endocytosis Sperm Entry Protein Localization To Tight Junction Positive Regulation Of Pinocytosis Regulation Of Endocytosis Intracellular Receptor Signaling Pathway Regulation Of Gene Expression, Epigenetic Positive Regulation Of Sodium:proton Antiporter Activity Response To Abiotic Stimulus Regulation Of Sodium:proton Antiporter Activity Peroxisome Proliferator Activated Receptor Signaling Pathway Protein Localization To Cell Junction DNA Methylation Involved In Embryo Development Dendritic Spine Maintenance Vesicle-mediated Transport Regulation Of Vesicle-mediated Transport Neuronal Ion Channel Clustering Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Proton Transport Negative Regulation Of Actin Nucleation Regulation Of Metabolic Process Positive Regulation Of Sodium Ion Transmembrane Transport Long Term Synaptic Depression Positive Regulation Of Receptor Internalization Prostate Gland Growth Regulation Of Arp2/3 Complex-mediated Actin Nucleation Dendritic Spine Organization DNA Methylation Involved In Gamete Generation Actin Crosslink Formation Regulation Of Actin Nucleation Cellular Response To Glucose Starvation Monoamine Transport Termination Of RNA Polymerase I Transcription Cellular Component Maintenance Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Retinoic Acid Receptor Signaling Pathway Regulation Of Sodium Ion Transmembrane Transporter Activity Neuron Maturation Regulation Of Receptor Internalization Transcription From RNA Polymerase I Promoter Regulation Of Gene Expression Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Sodium Ion Transport Retrograde Vesicle-mediated Transport, Golgi To ER Positive Regulation Of Receptor-mediated Endocytosis Protein K48-linked Ubiquitination Androgen Receptor Signaling Pathway Positive Regulation Of Transport
Tagcloud ?		agglutination air birds broth chickens gallisepticum mycoplasma p120 p200 p22 p24 p26 p28 p31 p33 p35 p40 p45 p50 p56 p60 p64 p72 p80 p98 plate spa synoviae