SACS and PICK1

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SACS	PICK1
Gene Name		sacsin molecular chaperone	protein interacting with PRKCA 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Axon Dendrite Cell Body Fiber	Cytoplasm Mitochondrion Golgi Apparatus Cytoskeleton Plasma Membrane Cell Junction Endocytic Vesicle Membrane Presynaptic Membrane Neuron Projection Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Neuronal Postsynaptic Density
	Molecular Function	Hsp70 Protein Binding Chaperone Binding Proteasome Binding	G-protein Coupled Receptor Binding Protein Kinase C Binding Receptor Binding Protein Binding Protein C-terminus Binding ATPase Activity Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Metal Ion Binding Actin Filament Binding Arp2/3 Complex Binding
	Biological Process	Protein Folding Negative Regulation Of Inclusion Body Assembly	Positive Regulation Of Receptor Internalization Protein Phosphorylation Protein Targeting Retrograde Vesicle-mediated Transport, Golgi To ER Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Monoamine Transport Glial Cell Development Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cellular Response To Decreased Oxygen Levels Cellular Response To Glucose Starvation DNA Methylation Involved In Embryo Development DNA Methylation Involved In Gamete Generation Receptor Clustering Neuronal Ion Channel Clustering Long Term Synaptic Depression Dendritic Spine Organization Dendritic Spine Maintenance
Pathways			Trafficking of GluR2-containing AMPA receptors Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Hypothyroidism ( 22493691) Protein quantitative trait loci ( 18464913) Type 2 diabetes ( 23300278)
Protein-Protein Interactions		5 interactors: ACTN4 PICK1 TSC22D4 UBE3A ZNRD1	47 interactors: APTX AQP1 ARF1 ARF3 ASIC1 ASIC2 ATXN1L ATXN3 ATXN7 ATXN7L3 BTG2 CIC COIL CTNNB1 EFNB1 EFNB2 EHD2 EPHB2 ERBB2 ERBB2IP F11R FXN GFI1 GFI1B GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRIK3 GRIP1 GRM3 GRM7 JAM3 LRP2BP MLLT4 PARK2 PRKCA PRKCG PRLHR PVRL2 PVRL4 SACS SLC6A3 UBQLN4 USP7
Entrez ID		26278	9463
HPRD ID		05135	16176
Ensembl ID		ENSG00000151835	ENSG00000100151
Uniprot IDs		Q9NZJ4	B3KS52 Q9NRD5
PDB IDs		1IUR 3O10	2GZV
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Endocytosis Sperm Entry Protein Localization To Tight Junction Positive Regulation Of Pinocytosis Regulation Of Endocytosis Intracellular Receptor Signaling Pathway Regulation Of Gene Expression, Epigenetic Positive Regulation Of Sodium:proton Antiporter Activity Response To Abiotic Stimulus Regulation Of Sodium:proton Antiporter Activity Peroxisome Proliferator Activated Receptor Signaling Pathway Protein Localization To Cell Junction DNA Methylation Involved In Embryo Development Dendritic Spine Maintenance Vesicle-mediated Transport Regulation Of Vesicle-mediated Transport Neuronal Ion Channel Clustering Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Proton Transport Negative Regulation Of Actin Nucleation Regulation Of Metabolic Process Positive Regulation Of Sodium Ion Transmembrane Transport Long Term Synaptic Depression Positive Regulation Of Receptor Internalization Prostate Gland Growth Regulation Of Arp2/3 Complex-mediated Actin Nucleation Dendritic Spine Organization DNA Methylation Involved In Gamete Generation Actin Crosslink Formation Regulation Of Actin Nucleation Cellular Response To Glucose Starvation Monoamine Transport Termination Of RNA Polymerase I Transcription Cellular Component Maintenance Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Retinoic Acid Receptor Signaling Pathway Regulation Of Sodium Ion Transmembrane Transporter Activity Neuron Maturation Regulation Of Receptor Internalization Transcription From RNA Polymerase I Promoter Regulation Of Gene Expression Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Sodium Ion Transport Retrograde Vesicle-mediated Transport, Golgi To ER Positive Regulation Of Receptor-mediated Endocytosis Protein K48-linked Ubiquitination Androgen Receptor Signaling Pathway Positive Regulation Of Transport	Cell-cell Signaling Synaptic Transmission Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Cellular Response To Stimulus Regulation Of Cellular Process Response To Stimulus Signaling Cell Communication Behavior Regulation Of Synaptic Transmission Single-organism Behavior Neurological System Process Negative Regulation Of Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic Signal Transduction Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Anatomical Structure Development Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Nervous System Development Negative Regulation Of Synaptic Transmission, Glutamatergic Cell Junction Assembly Developmental Process Ion Transport Cell-cell Junction Organization Ion Transmembrane Transport G-protein Coupled Glutamate Receptor Signaling Pathway Histone Deubiquitination Learning Or Memory Negative Regulation Of Adenylate Cyclase Activity Multicellular Organismal Development Regulation Of Body Fluid Levels Negative Regulation Of Lyase Activity Establishment Of Endothelial Barrier Cognition Response To External Stimulus System Development Regulation Of Signaling Adherens Junction Organization Multicellular Organismal Response To Stress Negative Regulation Of CAMP Biosynthetic Process Cellular Process Negative Regulation Of CAMP Metabolic Process Sensory Perception Of Sour Taste Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Death Negative Regulation Of Programmed Cell Death
Tagcloud ?		agglutination air birds broth chickens gallisepticum mycoplasma p120 p200 p22 p24 p26 p28 p31 p33 p35 p40 p45 p50 p56 p60 p64 p72 p80 p98 plate spa synoviae	altering ampa calsyntenin clarified confirming coordinated deprivation elicited excitotoxic glua1 glun2a glun2b glun3a grip1 hippocampal insults ionotropic ischemia ogd profound proteome repression sapap2 snap submitted synaptic tarpgamma3 transcriptome vulnerability
Tagcloud (Difference) ?		agglutination air birds broth chickens gallisepticum mycoplasma p120 p200 p22 p24 p26 p28 p31 p33 p35 p40 p45 p50 p56 p60 p64 p72 p80 p98 plate spa synoviae	altering ampa calsyntenin clarified confirming coordinated deprivation elicited excitotoxic glua1 glun2a glun2b glun3a grip1 hippocampal insults ionotropic ischemia ogd profound proteome repression sapap2 snap submitted synaptic tarpgamma3 transcriptome vulnerability
Tagcloud (Intersection) ?