CIC and SETD2

Number of citations of the paper that reports this interaction (PubMedID 16713569)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CIC	SETD2
Description		capicua transcriptional repressor	SET domain containing 2, histone lysine methyltransferase
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Protein-containing Complex	Nucleus Nucleoplasm Chromosome Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding	Protein Binding Methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Alpha-tubulin Binding Metal Ion Binding Histone H3K36 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K36 Trimethyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Brain Development Learning Memory Social Behavior Negative Regulation Of DNA-templated Transcription Lung Alveolus Development	Autophagosome Assembly Immune System Process DNA Repair Mismatch Repair Chromatin Organization Regulation Of DNA-templated Transcription Transcription Elongation By RNA Polymerase II DNA Damage Response Response To Metal Ion Regulation Of Gene Expression Proteasomal Protein Catabolic Process Positive Regulation Of Autophagy Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of MRNA Export From Nucleus Peptidyl-lysine Trimethylation Cell Differentiation Methylation Regulation Of Cytokinesis Positive Regulation Of Interferon-alpha Production Response To Type I Interferon Nucleosome Organization Endodermal Cell Differentiation Response To Alkaloid Innate Immune Response Positive Regulation Of Ossification Stem Cell Differentiation Defense Response To Virus Protein K48-linked Ubiquitination Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Protein Localization To Chromatin
Pathways			PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Bitter alcoholic beverage consumption ( 31046077) Neutrophil count ( 32888494)	Adult body size ( 32376654) Basophil count ( 32888494) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 24097068 30275531) HDL cholesterol levels ( 28334899) Huntington's disease progression ( 28642124) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Mean platelet volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) White blood cell count ( 27863252 32888494) White blood cell count (basophil) ( 27863252)
Interacting Genes		13 interacting genes: ATXN1 CPAP CSNK2B GABPB1 GOLGA2 GTPBP3 NFYC PICK1 POLR1H PYCR2 SEC62 SETD2 TRIM22	10 interacting genes: ARX ATXN1 CIC H3-4 H3C1 HTT SHANK3 SIAH2 SMAD3 SPOP
Entrez ID		23152	29072
HPRD ID		10831	11043
Ensembl ID		ENSG00000079432	ENSG00000181555
Uniprot IDs		A0A0A0MQR4 I3L2J0 Q96RK0	A0A1W2PPX9 Q9BYW2
PDB IDs		2M41 4J2J 4J2L 6JRP 6KZG 6KZH	2A7O 2MDC 2MDI 2MDJ 4FMU 4H12 5JJY 5JLB 5JLE 5LSS 5LSX 5LSY 5LSZ 5LT6 5LT7 5LT8 5V21 5V22 6J9J 6VDB 7EA8 7EVR 7EVS 7LZB 7LZD 7LZF 7TY2 7TY3 8Q5P 8RZU 9EGZ 9EH0 9EH1 9EH2
Enriched GO Terms of Interacting Partners?			Vocal Learning Learning Social Behavior Observational Learning Auditory Behavior Learning Or Memory Mechanosensory Behavior Cognition Memory Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Chromatin Binding Proteasomal Protein Catabolic Process Lung Alveolus Development
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