CIC and CPAP

Number of citations of the paper that reports this interaction (PubMedID 16713569)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (two hybrid)

		CIC	CPAP
Description		capicua transcriptional repressor	centrosome assembly and centriole elongation protein
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Protein-containing Complex	Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Microtubule Gamma-tubulin Small Complex Ciliary Basal Body Procentriole Replication Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding	Transcription Coactivator Activity Protein Binding Tubulin Binding Protein Kinase Binding Protein Domain Specific Binding Identical Protein Binding Gamma-tubulin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Brain Development Learning Memory Social Behavior Negative Regulation Of DNA-templated Transcription Lung Alveolus Development	Microtubule Nucleation Centriole Replication Smoothened Signaling Pathway Astral Microtubule Nucleation Motile Cilium Assembly Positive Regulation Of DNA-templated Transcription Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Centriole Replication Positive Regulation Of Centriole Replication Microtubule Polymerization Centrosome Duplication Cell Division Regulation Of Mitotic Spindle Organization Cilium Assembly Centriole Elongation Centriole Assembly Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Organelle Assembly Positive Regulation Of Non-motile Cilium Assembly Positive Regulation Of Centriole Elongation Positive Regulation Of Establishment Of Protein Localization Non-motile Cilium Assembly Positive Regulation Of Spindle Assembly
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain AURKA Activation by TPX2
Drugs
Diseases			Primary microcephaly (MCPH) Seckel syndrome
GWAS		Bitter alcoholic beverage consumption ( 31046077) Neutrophil count ( 32888494)
Interacting Genes		13 interacting genes: ATXN1 CPAP CSNK2B GABPB1 GOLGA2 GTPBP3 NFYC PICK1 POLR1H PYCR2 SEC62 SETD2 TRIM22	16 interacting genes: ATN1 BCCIP CIC CREBBP EPB41 FBXO7 GFI1B LAG3 LYST MTDH SHANK3 STAT5A STAT5B TUBG1 YWHAG YWHAZ
Entrez ID		23152	55835
HPRD ID		10831	09876
Ensembl ID		ENSG00000079432	ENSG00000151849
Uniprot IDs		A0A0A0MQR4 I3L2J0 Q96RK0	A8K8P1 F6VUX8 Q9HC77
PDB IDs		2M41 4J2J 4J2L 6JRP 6KZG 6KZH	5EIB 5ITZ 7Q1E 7Q1F 7Z0F 7Z0G
Enriched GO Terms of Interacting Partners?			Natural Killer Cell Mediated Immunity Natural Killer Cell Mediated Cytotoxicity Cell Killing Leukocyte Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Development Of Secondary Female Sexual Characteristics Development Of Secondary Male Sexual Characteristics Lymphocyte Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Lymphocyte Mediated Immunity Leukocyte Mediated Immunity Development Of Secondary Sexual Characteristics Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Lymphocyte Activation Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Interleukin-2 Production Negative Regulation Of Lymphocyte Differentiation Negative Regulation Of Leukocyte Activation Positive Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Gamma-delta T Cell Differentiation Mucosa-associated Lymphoid Tissue Development Peyer's Patch Development Luteinization Negative Regulation Of Erythrocyte Differentiation Activated T Cell Proliferation Regulation Of Immune System Process Regulation Of Hemopoiesis Positive Regulation Of Cell Killing Taurine Metabolic Process Positive Regulation Of Natural Killer Cell Differentiation Regulation Of Innate Immune Response Negative Regulation Of Cell Activation Regulation Of Lymphocyte Differentiation Positive Regulation Of Gamma-delta T Cell Activation Gamma-delta T Cell Differentiation Regulation Of Gamma-delta T Cell Differentiation Regulation Of Cell Development Regulation Of Natural Killer Cell Differentiation Regulation Of Lymphocyte Activation Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Immune Effector Process Negative Regulation Of Immune System Process Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Developmental Process Myeloid Cell Apoptotic Process Positive Regulation Of B Cell Differentiation Regulation Of Immune Response Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Innate Immune Response
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