CIC and PYCR2

Number of citations of the paper that reports this interaction (PubMedID 16713569)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CIC	PYCR2
Description		capicua transcriptional repressor	pyrroline-5-carboxylate reductase 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Protein-containing Complex	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding	Pyrroline-5-carboxylate Reductase Activity Protein Binding Oxidoreductase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Brain Development Learning Memory Social Behavior Negative Regulation Of DNA-templated Transcription Lung Alveolus Development	Amino Acid Biosynthetic Process Cellular Response To Oxidative Stress L-proline Biosynthetic Process
Pathways			Glutamate and glutamine metabolism
Drugs			NADH Proline
Diseases
GWAS		Bitter alcoholic beverage consumption ( 31046077) Neutrophil count ( 32888494)
Interacting Genes		13 interacting genes: ATXN1 CPAP CSNK2B GABPB1 GOLGA2 GTPBP3 NFYC PICK1 POLR1H PYCR2 SEC62 SETD2 TRIM22	6 interacting genes: APP CIC FXR1 FXR2 SKIL UBE4B
Entrez ID		23152	29920
HPRD ID		10831	17939
Ensembl ID		ENSG00000079432	ENSG00000143811
Uniprot IDs		A0A0A0MQR4 I3L2J0 Q96RK0	A0A087WTV6 A0A0S2Z5U6 Q96C36
PDB IDs		2M41 4J2J 4J2L 6JRP 6KZG 6KZH	6LHM
Enriched GO Terms of Interacting Partners?			Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Long-term Synaptic Potentiation Translation Regulator Activity Regulation Of Synaptic Plasticity Dentate Gyrus Development Presynapse Postsynapse Positive Regulation Of Neurogenesis Positive Regulation Of Nervous System Development Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Cell Differentiation Neuron Projection Protein Heterodimerization Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Neurogenesis Negative Regulation Of Biosynthetic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Translation Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Cell Development Regulation Of Nervous System Development Cytoplasmic Ribonucleoprotein Granule Granzyme-mediated Apoptotic Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Chromatin Binding Modulation Of Chemical Synaptic Transmission Cytoplasmic Stress Granule Positive Regulation Of Developmental Process MRNA Destabilization RNA Destabilization Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Acetylcholine Receptor Activator Activity Positive Regulation Of Catabolic Process Lipoprotein Particle Developmental Process Positive Regulation Of Protein Import Positive Regulation Of MRNA Catabolic Process Memory Negative Regulation Of Nucleobase-containing Compound Metabolic Process Post-transcriptional Regulation Of Gene Expression MRNA Transport
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