HGF and YWHAG

Number of citations of the paper that reports this interaction (PubMedID 28205554)
55

Data Source:
BioGRID (fluorescent resonance energy transfer)

		HGF	YWHAG
Description		hepatocyte growth factor	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane Platelet Alpha Granule Lumen	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Focal Adhesion Membrane Vesicle Synapse Extracellular Exosome Presynapse
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Growth Factor Activity Chemoattractant Activity Identical Protein Binding	RNA Binding Protein Kinase C Binding Insulin-like Growth Factor Receptor Binding Protein Binding Protein Kinase C Inhibitor Activity Protein Domain Specific Binding Receptor Tyrosine Kinase Binding Identical Protein Binding Phosphorylation-dependent Protein Binding Protein Sequestering Activity
	Biological Process	Mitotic Cell Cycle Cell Morphogenesis Epithelial To Mesenchymal Transition Liver Development Proteolysis Signal Transduction Negative Regulation Of Autophagy Skeletal Muscle Cell Proliferation Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Cell Migration Negative Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-10 Production Cellular Response To Hepatocyte Growth Factor Stimulus Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Hepatocyte Growth Factor Receptor Signaling Pathway Animal Organ Development Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Positive Chemotaxis Regulation Of Multicellular Organismal Process Myoblast Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Chemotaxis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of P38MAPK Cascade Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of DNA Biosynthetic Process	Cytoplasmic Translation Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Negative Regulation Of Protein Kinase Activity Protein Targeting Signal Transduction Intracellular Protein Localization Regulation Of Signal Transduction Positive Regulation Of Cell-cell Adhesion SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Cellular Response To Insulin Stimulus Regulation Of Protein Localization Cellular Response To Amino Acid Starvation TORC1 Signaling Cellular Response To Glucose Starvation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Neuron Differentiation Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Regulation Of Synaptic Plasticity Protein Stabilization Negative Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Protein Localization To Lysosome Protein K6-linked Ubiquitination Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		Platelet degranulation PIP3 activates AKT signaling Interleukin-7 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling MET Receptor Activation Negative regulation of MET activity PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates RAS signaling MET activates PI3K/AKT signaling MET activates PTPN11 MET activates PTK2 signaling MET interacts with TNS proteins MET activates RAP1 and RAC1 MET receptor recycling MET activates STAT3 Drug-mediated inhibition of MET activation	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex AURKA Activation by TPX2 Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity SPOP-mediated proteasomal degradation of PD-L1(CD274)
Drugs		Valproic acid Heparin O2-Sulfo-Glucuronic Acid N,O6-Disulfo-Glucosamine ABT-510 Foretinib
Diseases
GWAS		Blood protein levels ( 30072576) Endothelial growth factor levels ( 25552591) Gestational age at birth (maternal effect) ( 28598419) Gout ( 22179738) Gout (normal type) ( 32238385) Hepatocyte growth factor levels ( 25998175 27989323) Intraocular pressure ( 29235454 29785010) Rosacea symptom severity ( 29771307) Spontaneous preterm birth (maternal effect) ( 28598419) Transverse temporal cortex volume ( 31530798) Tuberculosis ( 29036319)	Multiple sclerosis ( 21654844) Schizophrenia ( 30285260)
Interacting Genes		36 interacting genes: ADAMTSL4 ARNT BRCA1 CCND2 CDK4 CDK6 CDKN2A CDKN2B CLEC3B EPHA2 ERBB2 F11 FGFR4 FN1 GLIS2 HGFAC HPN KLKB1 LATS2 LCN2 MAP2K5 MAP2K6 MDM4 MEOX2 MET NF2 PDGFRA PLAU RAF1 SDC1 SDC2 ST14 STK11 TEAD2 VTN YWHAG	286 interacting genes: ABL1 ABLIM1 ACIN1 AFDN AKAP13 AKT1S1 ALB ANKHD1-EIF4EBP3 ANKS1A APP ARAF ARHGEF2 ARHGEF6 ARHGEF7 ATP5F1A ATP5F1B ATP6V0B BAD BAIAP2 BAIAP2L1 BCLAF1 BCR BRAF C1QBP CAD CAMKK1 CASP3 CBL CCNY CCS CCT2 CDC5L CDK11B CDK16 CDK17 CDKN1B CEP170 CEP250 CEP95 CFAP20 CFL1 CGN CGNL1 CHAF1A CHEK1 CKAP2 CLASP1 CLINT1 CLK1 CLK2 CLK3 CLTC COPS5 CPAP CPSF3 CRTC1 CRTC2 CRTC3 CSE1L CTNND1 CTPS1 CYFIP2 DCAF7 DCP1A DDX17 DDX27 DDX39B DENND4A DFFA DHX15 DISC1 DOCK7 DYNC1H1 DYRK1A EDC3 EEF1A1 EEF1G EML3 EPB41L3 EPN2 ERC1 EWSR1 EXO1 FAM13B FARP2 FGD6 FLNA FOXO1 FOXO3 GBF1 GIT1 GIT2 GSK3A GTPBP4 H3C1 HDAC4 HDAC7 HECTD1 HGF HNRNPAB HNRNPH1 HNRNPM HOXC10 HSPA1A HSPA8 HSPA9 HSPB6 HSPD1 IGF1R IL7R ING1 INPP5E IRS1 IRS2 IRS4 JAKMIP1 KANK1 KAT5 KCNK15 KCNK3 KCNK9 KIAA0408 KIAA0930 KIF1B KIF1C KIF23 KIF5B KIF5C KLC2 KLC3 KRT18 LARP1 LATS2 LBR LIMA1 LMO7 LRCH3 LSR LTB4R LUC7L2 LUC7L3 MAGOHB MAP3K2 MAP3K20 MAP3K3 MAPKAP1 MARK3 MCM5 MDM4 MFAP1 MICALL1 MIEF1 MPHOSPH9 MPRIP MSL2 MYCBP2 MYH10 N4BP3 NCAM2 NCKAP1 NCKIPSD NDE1 NDEL1 NEDD4L NEFL NHSL2 NOLC1 NUFIP2 NUMBL OSBPL3 P4HB PABPC1 PAK1 PAK4 PARD3 PARD3B PFKFB2 PGAM5 PHLDB2 PI4KB PIK3C3 PIK3R1 PKP2 PLA2G12A PLEKHA5 PNN POT1 PPFIA1 PPFIBP1 PPIG PPP1R12A PPP6R3 PRKCA PRKCB PRKCD PRKCG PRKCQ PRKDC PRLR PRMT1 PRMT5 PRP4K PRPF38B PRPF40A PTPN14 PUF60 RAB11FIP2 RAB11FIP5 RABEP1 RACGAP1 RAF1 RAI14 RALGPS2 RAPGEF6 RASAL2 RASSF8 RGS12 RIPK2 RIPOR2 RMDN3 RNPS1 RPS2 RRM1 SAMD4A SAMD4B SF3B3 SFN SH3BP4 SH3BP5L SHKBP1 SHPRH SHROOM2 SIMC1 SLC25A3 SMARCD1 SNRNP200 SON SPOP SPTBN1 SRC SRGAP2 SRPK1 SRRM1 SRRM2 SRSF10 SRSF3 STK11 SVIL SYNPO SYNPO2 TAB1 TAF15 TBC1D1 TBC1D4 TERF1 TFE3 THRAP3 TIAM1 TINF2 TJP2 TMEM102 TNFAIP3 TP53 TP53BP2 TRA2A TRA2B TSC1 TSC2 TUBA4A TUBB TUBB4A UBC UBE3A UCP2 UCP3 USP37 USP8 WEE1 WNK1 YAP1 YWHAB YWHAE YWHAH YWHAQ ZBTB21 ZFP36
Entrez ID		3082	7532
HPRD ID		00799	05639
Ensembl ID		ENSG00000019991	ENSG00000170027
Uniprot IDs		P14210	P61981
PDB IDs		1BHT 1GMN 1GMO 1GP9 1NK1 1SHY 1SI5 2HGF 2QJ2 3HMS 3HMT 3HN4 3MKP 3SP8 4D3C 4K3J 4O3T 4O3U 5COE 5CP9 5CS1 5CS3 5CS5 5CS9 5CSQ 5CT1 5CT2 5CT3 7MO7 7MO8 7MO9 7MOA 7MOB 7OCL 7OCM	2B05 3UZD 4E2E 4J6S 4O46 5D3E 6A5S 6BYJ 6BYL 6BZD 6FEL 6GKF 6GKG 6S9K 6SAD 6Y4K 6Y6B 6ZBT 6ZC9 7A6R 7A6Y
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Negative Regulation Of Multicellular Organismal Process Kinase Activity Regulation Of Cell Population Proliferation Protein Tyrosine Kinase Activity Regulation Of Protein Metabolic Process Signal Transduction Cellular Developmental Process Developmental Process Cell Differentiation Regulation Of Fibrinolysis Animal Organ Development Negative Regulation Of Blood Coagulation Regulation Of Epithelial Cell Proliferation Negative Regulation Of Hemostasis Transmembrane Receptor Protein Tyrosine Kinase Activity Negative Regulation Of Coagulation Regulation Of Multicellular Organismal Process Serine-type Peptidase Activity Regulation Of Signal Transduction Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Cellular Component Organization Positive Regulation Of Protein Metabolic Process Serine-type Endopeptidase Activity Positive Regulation Of Macromolecule Biosynthetic Process Cell Surface Receptor Signaling Pathway Zymogen Activation Positive Regulation Of Biosynthetic Process Plasminogen Activation Positive Regulation Of Signal Transduction Regulation Of Developmental Process Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Macromolecule Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Maturation Positive Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Cell Adhesion Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Metabolic Process Regulation Of Cell Motility Protein Metabolic Process Positive Regulation Of Fibroblast Proliferation Regulation Of Plasminogen Activation Regulation Of Cell-substrate Adhesion Enzyme-linked Receptor Protein Signaling Pathway	Cytosol Cytoplasm Protein Binding Regulation Of Supramolecular Fiber Organization RNA Splicing Cadherin Binding Cytoskeleton Regulation Of Protein Localization Regulation Of Cellular Component Organization Regulation Of Organelle Organization Protein Serine Kinase Activity ATP Binding Regulation Of Cytoskeleton Organization Protein Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of RNA Splicing Nucleus RNA Binding MRNA Metabolic Process Nucleotide Binding Cellular Component Assembly Focal Adhesion Intracellular Signal Transduction Kinase Activity Organelle Organization Cytoskeleton Organization MRNA Splicing, Via Spliceosome Microtubule RNA Splicing, Via Transesterification Reactions Nucleoplasm Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing MRNA Processing Regulation Of Cell Cycle Positive Regulation Of Cellular Component Organization Regulation Of Protein Metabolic Process Small GTPase Binding Nuclear Speck Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Protein-containing Complex Regulation Of Programmed Cell Death Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Actin Filament Organization Macromolecule Metabolic Process Protein Phosphorylation Anchoring Junction Negative Regulation Of Supramolecular Fiber Organization Protein Domain Specific Binding Phosphorylation
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