HGF and LCN2

Number of citations of the paper that reports this interaction (PMID 15637066)
22

Data Source:
HPRD (in vitro)

		HGF	LCN2
Gene Name		hepatocyte growth factor (hepapoietin A; scatter factor)	lipocalin 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane Platelet Alpha Granule Lumen	Extracellular Region Extracellular Space Cytosol Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Growth Factor Activity Chemoattractant Activity Identical Protein Binding Protein Heterodimerization Activity	Protease Binding Transporter Activity Iron Ion Binding Small Molecule Binding Protein Homodimerization Activity
	Biological Process	Activation Of MAPK Activity Epithelial To Mesenchymal Transition Liver Development Platelet Degranulation Proteolysis Mitotic Nuclear Division Blood Coagulation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Platelet Activation Hyaluronan Metabolic Process Positive Regulation Of Cell Migration Organ Regeneration Positive Regulation Of Myelination Cellular Response To Hepatocyte Growth Factor Stimulus Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Hepatocyte Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Myoblast Proliferation Cell Chemotaxis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Positive Regulation Of Neuron Projection Regeneration Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of DNA Biosynthetic Process	Ion Transport Cellular Iron Ion Homeostasis Response To Virus Response To Herbicide Positive Regulation Of Gene Expression Siderophore Transport Positive Regulation Of Cell Projection Organization Cellular Response To Nutrient Levels Response To Drug Innate Immune Response Transmembrane Transport Protein Homotrimerization Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Signaling by Interleukins Response to elevated platelet cytosolic Ca2+ Interleukin-7 signaling Cytokine Signaling in Immune system Platelet degranulation Platelet activation, signaling and aggregation	Iron uptake and transport Orphan transporters
Drugs		O2-Sulfo-Glucuronic Acid N,O6-Disulfo-Glucosamine	Methyl Nonanoate (Ester) 2,3-Dihydroxy-Benzoic Acid Carboxymycobactin S 2,3,-Dihydroxybenzoylserine Alpha-D-Mannose Carboxymycobactin T Trencam-3,2-Hopo
Diseases
GWAS
Protein-Protein Interactions		16 interactors: ADAMTSL4 BRCA1 CLEC3B F11 FN1 HGFAC HPN KLKB1 LCN2 MEOX2 MET PLAU SDC1 SDC2 ST14 VTN	4 interactors: HGF LRP2 MMP2 MMP9
Entrez ID		3082	3934
HPRD ID		00799	02551
Ensembl ID		ENSG00000019991	ENSG00000148346
Uniprot IDs		P14210	P80188
PDB IDs		1BHT 1GMN 1GMO 1GP9 1NK1 1SHY 1SI5 2HGF 2QJ2 3HMS 3HMT 3HN4 3MKP 3SP8 4K3J	1DFV 1L6M 1NGL 1QQS 1X71 1X89 1X8U 3BY0 3CBC 3CMP 3DSZ 3DTQ 3FW4 3FW5 3HWD 3HWE 3HWF 3HWG 3I0A 3K3L 3PEC 3PED 3T1D 3TF6 3TZS 3U03 3U0D 4GH7 4IAW 4IAX 4K19
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Positive Regulation Of Protein Processing Regulation Of Blood Coagulation Regulation Of Wound Healing Wound Healing Positive Regulation Of Fibrinolysis Response To Wounding Positive Regulation Of Plasminogen Activation Positive Regulation Of Protein Metabolic Process Plasminogen Activation Protein Metabolic Process Proteolysis Extracellular Matrix Disassembly Regulation Of Fibrinolysis Blood Coagulation, Intrinsic Pathway Tissue Development Positive Regulation Of Metabolic Process Response To Stress Regulation Of Protein Processing Regulation Of Cellular Component Organization Blood Coagulation Hemostasis Fibrinolysis Detection Of Abiotic Stimulus Multicellular Organismal Development Regulation Of Protein Metabolic Process Endodermal Cell Differentiation Anatomical Structure Development Muscle Cell Migration Regulation Of Smooth Muscle Cell Migration Cell Death Regulation Of Body Fluid Levels Death Anatomical Structure Morphogenesis Response To Abiotic Stimulus Endoderm Formation Glycosaminoglycan Catabolic Process Embryo Development Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Chondroitin Sulfate Metabolic Process Response To External Stimulus Developmental Process Response To Stimulus Regulation Of Acute Inflammatory Response Acute Inflammatory Response	Endodermal Cell Differentiation Endoderm Formation Response To External Stimulus Collagen Catabolic Process Embryo Implantation Collagen Metabolic Process Chemotaxis Multicellular Organismal Macromolecule Metabolic Process Endoderm Development Multicellular Organismal Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Extracellular Matrix Disassembly Ephrin Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Formation Of Primary Germ Layer Enzyme Linked Receptor Protein Signaling Pathway Organ Development Cell Morphogenesis Gastrulation Locomotion Female Pregnancy Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Receptor Binding Myoblast Proliferation Positive Regulation Of Keratinocyte Migration Ossification Hepatocyte Growth Factor Receptor Signaling Pathway Movement Of Cell Or Subcellular Component System Development Generation Of Neurons Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Neurogenesis Cellular Response To Hepatocyte Growth Factor Stimulus Intramembranous Ossification Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Extracellular Matrix Organization Extracellular Structure Organization Tissue Development Positive Regulation Of Myelination Axon Guidance Bone Trabecula Formation Multicellular Organismal Development Cell Development Positive Regulation Of Neuron Projection Regeneration Anatomical Structure Development Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Tagcloud ?		amifostine anticancer benefits csf cytoprotective decitabine demethylating developments emerging gm granulocyte hematologic hematopoietic hgfs improvements includes infectious introduced issues keratinocyte kgf prophylactic renewed risks supportive thrombopoietin topics transfusional transfusions	adipocyte adipocytes adipokine adipose adiposity bdh2 brca butyrate circulating combat conditioned considering constitute dehydrogenase deletion eralpha ferko heightened hydroxy lipocalin media microenvironment migratory pad promotes pure repress responsiveness slc22a17
Tagcloud (Difference) ?		amifostine anticancer benefits csf cytoprotective decitabine demethylating developments emerging gm granulocyte hematologic hematopoietic hgfs improvements includes infectious introduced issues keratinocyte kgf prophylactic renewed risks supportive thrombopoietin topics transfusional transfusions	adipocyte adipocytes adipokine adipose adiposity bdh2 brca butyrate circulating combat conditioned considering constitute dehydrogenase deletion eralpha ferko heightened hydroxy lipocalin media microenvironment migratory pad promotes pure repress responsiveness slc22a17
Tagcloud (Intersection) ?