HGF and HGFAC

Number of citations of the paper that reports this interaction (PMID 8631970)
14

Data Source:
HPRD (in vitro)

		HGF	HGFAC
Gene Name		hepatocyte growth factor (hepapoietin A; scatter factor)	HGF activator
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane Platelet Alpha Granule Lumen	Extracellular Region Extracellular Space
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Growth Factor Activity Chemoattractant Activity Identical Protein Binding Protein Heterodimerization Activity	Serine-type Endopeptidase Activity Serine-type Peptidase Activity
	Biological Process	Activation Of MAPK Activity Epithelial To Mesenchymal Transition Liver Development Platelet Degranulation Proteolysis Mitotic Nuclear Division Blood Coagulation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Platelet Activation Hyaluronan Metabolic Process Positive Regulation Of Cell Migration Organ Regeneration Positive Regulation Of Myelination Cellular Response To Hepatocyte Growth Factor Stimulus Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Hepatocyte Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Myoblast Proliferation Cell Chemotaxis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Positive Regulation Of Neuron Projection Regeneration Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of DNA Biosynthetic Process	Proteolysis
Pathways		Signaling by Interleukins Response to elevated platelet cytosolic Ca2+ Interleukin-7 signaling Cytokine Signaling in Immune system Platelet degranulation Platelet activation, signaling and aggregation
Drugs		O2-Sulfo-Glucuronic Acid N,O6-Disulfo-Glucosamine
Diseases
GWAS
Protein-Protein Interactions		16 interactors: ADAMTSL4 BRCA1 CLEC3B F11 FN1 HGFAC HPN KLKB1 LCN2 MEOX2 MET PLAU SDC1 SDC2 ST14 VTN	5 interactors: F2 HGF KLKB1 SPINT1 SPINT2
Entrez ID		3082	3083
HPRD ID		00799	05184
Ensembl ID		ENSG00000019991	ENSG00000109758
Uniprot IDs		P14210	D6RAR4 Q04756
PDB IDs		1BHT 1GMN 1GMO 1GP9 1NK1 1SHY 1SI5 2HGF 2QJ2 3HMS 3HMT 3HN4 3MKP 3SP8 4K3J	1YBW 1YC0 2R0K 2R0L 2WUB 2WUC 3K2U
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Positive Regulation Of Protein Processing Regulation Of Blood Coagulation Regulation Of Wound Healing Wound Healing Positive Regulation Of Fibrinolysis Response To Wounding Positive Regulation Of Plasminogen Activation Positive Regulation Of Protein Metabolic Process Plasminogen Activation Protein Metabolic Process Proteolysis Extracellular Matrix Disassembly Regulation Of Fibrinolysis Blood Coagulation, Intrinsic Pathway Tissue Development Positive Regulation Of Metabolic Process Response To Stress Regulation Of Protein Processing Regulation Of Cellular Component Organization Blood Coagulation Hemostasis Fibrinolysis Detection Of Abiotic Stimulus Multicellular Organismal Development Regulation Of Protein Metabolic Process Endodermal Cell Differentiation Anatomical Structure Development Muscle Cell Migration Regulation Of Smooth Muscle Cell Migration Cell Death Regulation Of Body Fluid Levels Death Anatomical Structure Morphogenesis Response To Abiotic Stimulus Endoderm Formation Glycosaminoglycan Catabolic Process Embryo Development Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Chondroitin Sulfate Metabolic Process Response To External Stimulus Developmental Process Response To Stimulus Regulation Of Acute Inflammatory Response Acute Inflammatory Response	Regulation Of Protein Processing Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Fibrinolysis Regulation Of Proteolysis Blood Coagulation, Intrinsic Pathway Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Fibrinolysis Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Peptidase Activity Negative Regulation Of Blood Coagulation Blood Coagulation Hemostasis Negative Regulation Of Coagulation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Wound Healing Acute Inflammatory Response Regulation Of Body Fluid Levels Regulation Of Phosphatidylinositol 3-kinase Signaling Wound Healing Regulation Of Blood Coagulation Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Response To Wounding Negative Regulation Of Cellular Metabolic Process Regulation Of Wound Healing Negative Regulation Of Catalytic Activity Factor XII Activation Protein Activation Cascade Platelet Activation Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Myoblast Proliferation Positive Regulation Of Fibrinolysis Hepatocyte Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Plasminogen Activation Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Positive Regulation Of Myelination Plasma Kallikrein-kinin Cascade Branching Involved In Labyrinthine Layer Morphogenesis Negative Regulation Of Fibrinolysis Positive Regulation Of Neuron Projection Regeneration Movement Of Cell Or Subcellular Component Extracellular Matrix Organization
Tagcloud ?		amifostine anticancer benefits csf cytoprotective decitabine demethylating developments emerging gm granulocyte hematologic hematopoietic hgfs improvements includes infectious introduced issues keratinocyte kgf prophylactic renewed risks supportive thrombopoietin topics transfusional transfusions	ascertain biovu chance clinician cngb3 compelling convulsions emr f5 gpr98 homozygotes inferred inheritance macular maf mendelian nssnp nssnps omim permuted platforms refine rs13157270 rs16844401 rs3735972 rs6031 synonymous twleve vanderbilt
Tagcloud (Difference) ?		amifostine anticancer benefits csf cytoprotective decitabine demethylating developments emerging gm granulocyte hematologic hematopoietic hgfs improvements includes infectious introduced issues keratinocyte kgf prophylactic renewed risks supportive thrombopoietin topics transfusional transfusions	ascertain biovu chance clinician cngb3 compelling convulsions emr f5 gpr98 homozygotes inferred inheritance macular maf mendelian nssnp nssnps omim permuted platforms refine rs13157270 rs16844401 rs3735972 rs6031 synonymous twleve vanderbilt
Tagcloud (Intersection) ?