HGF and KLKB1

Number of citations of the paper that reports this interaction (PubMedID 12372819)
0

Data Source:
HPRD (in vitro)

		HGF	KLKB1
Description		hepatocyte growth factor	kallikrein B1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane Platelet Alpha Granule Lumen	Extracellular Region Extracellular Space Plasma Membrane Extracellular Exosome
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Growth Factor Activity Chemoattractant Activity Identical Protein Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Mitotic Cell Cycle Cell Morphogenesis Epithelial To Mesenchymal Transition Liver Development Proteolysis Signal Transduction Negative Regulation Of Autophagy Skeletal Muscle Cell Proliferation Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Cell Migration Negative Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-10 Production Cellular Response To Hepatocyte Growth Factor Stimulus Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Hepatocyte Growth Factor Receptor Signaling Pathway Animal Organ Development Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Positive Chemotaxis Regulation Of Multicellular Organismal Process Myoblast Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Chemotaxis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of P38MAPK Cascade Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of DNA Biosynthetic Process	Factor XII Activation Proteolysis Inflammatory Response Blood Coagulation Hemostasis Zymogen Activation Plasminogen Activation Fibrinolysis Positive Regulation Of Fibrinolysis
Pathways		Platelet degranulation PIP3 activates AKT signaling Interleukin-7 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling MET Receptor Activation Negative regulation of MET activity PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates RAS signaling MET activates PI3K/AKT signaling MET activates PTPN11 MET activates PTK2 signaling MET interacts with TNS proteins MET activates RAP1 and RAC1 MET receptor recycling MET activates STAT3 Drug-mediated inhibition of MET activation	Intrinsic Pathway of Fibrin Clot Formation Activation of Matrix Metalloproteinases Defective factor XII causes hereditary angioedema Defective SERPING1 causes hereditary angioedema
Drugs		Valproic acid Heparin O2-Sulfo-Glucuronic Acid N,O6-Disulfo-Glucosamine ABT-510 Foretinib	Zinc Ecallantide Human C1-esterase inhibitor Conestat alfa Gabexate Zinc acetate Zinc chloride Zinc sulfate, unspecified form Lanadelumab Berotralstat
Diseases			Fletcher factor deficiency; Prekallikrein deficiency
GWAS		Blood protein levels ( 30072576) Endothelial growth factor levels ( 25552591) Gestational age at birth (maternal effect) ( 28598419) Gout ( 22179738) Gout (normal type) ( 32238385) Hepatocyte growth factor levels ( 25998175 27989323) Intraocular pressure ( 29235454 29785010) Rosacea symptom severity ( 29771307) Spontaneous preterm birth (maternal effect) ( 28598419) Transverse temporal cortex volume ( 31530798) Tuberculosis ( 29036319)	Apolipoprotein A-IV levels ( 27412012) B-type natriuretic peptide levels ( 25561047) Cardiac troponin-I levels ( 31014085) Circulating chromogranin peptide levels ( 28011710) Circulating vasoactive peptide levels ( 23381795) Glycine levels ( 30837465) L-arginine levels ( 27656708) Metabolic traits ( 21886157) Metabolite levels ( 22916037 22286219) Obesity-related traits ( 23251661) Plasma renin activity levels ( 25477429) Response to statin therapy ( 20339536) Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 24625756 23093944 33031748) Venous thromboembolism ( 30659681)
Interacting Genes		36 interacting genes: ADAMTSL4 ARNT BRCA1 CCND2 CDK4 CDK6 CDKN2A CDKN2B CLEC3B EPHA2 ERBB2 F11 FGFR4 FN1 GLIS2 HGFAC HPN KLKB1 LATS2 LCN2 MAP2K5 MAP2K6 MDM4 MEOX2 MET NF2 PDGFRA PLAU RAF1 SDC1 SDC2 ST14 STK11 TEAD2 VTN YWHAG	8 interacting genes: F12 HGF HGFAC IGFBP3 KNG1 MST1 SERPINA5 TFPI2
Entrez ID		3082	3818
HPRD ID		00799	01971
Ensembl ID		ENSG00000019991	ENSG00000164344
Uniprot IDs		P14210	A8K9A9 B4DMX2 E9PBC5 P03952
PDB IDs		1BHT 1GMN 1GMO 1GP9 1NK1 1SHY 1SI5 2HGF 2QJ2 3HMS 3HMT 3HN4 3MKP 3SP8 4D3C 4K3J 4O3T 4O3U 5COE 5CP9 5CS1 5CS3 5CS5 5CS9 5CSQ 5CT1 5CT2 5CT3 7MO7 7MO8 7MO9 7MOA 7MOB 7OCL 7OCM	2ANW 2ANY 4OGX 4OGY 5F8T 5F8X 5F8Z 5TJX 6I44 6O1G 6O1S 6T7P 7N7X 7QOX 8A3Q 8FGX
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Negative Regulation Of Multicellular Organismal Process Kinase Activity Regulation Of Cell Population Proliferation Protein Tyrosine Kinase Activity Regulation Of Protein Metabolic Process Signal Transduction Cellular Developmental Process Developmental Process Cell Differentiation Regulation Of Fibrinolysis Animal Organ Development Negative Regulation Of Blood Coagulation Regulation Of Epithelial Cell Proliferation Negative Regulation Of Hemostasis Transmembrane Receptor Protein Tyrosine Kinase Activity Negative Regulation Of Coagulation Regulation Of Multicellular Organismal Process Serine-type Peptidase Activity Regulation Of Signal Transduction Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Cellular Component Organization Positive Regulation Of Protein Metabolic Process Serine-type Endopeptidase Activity Positive Regulation Of Macromolecule Biosynthetic Process Cell Surface Receptor Signaling Pathway Zymogen Activation Positive Regulation Of Biosynthetic Process Plasminogen Activation Positive Regulation Of Signal Transduction Regulation Of Developmental Process Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Macromolecule Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Maturation Positive Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Cell Adhesion Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Metabolic Process Regulation Of Cell Motility Protein Metabolic Process Positive Regulation Of Fibroblast Proliferation Regulation Of Plasminogen Activation Regulation Of Cell-substrate Adhesion Enzyme-linked Receptor Protein Signaling Pathway	Extracellular Space Extracellular Region Coagulation Blood Coagulation Hemostasis Extracellular Matrix Regulation Of Body Fluid Levels Peptidase Inhibitor Activity Serine-type Endopeptidase Activity Rough Endoplasmic Reticulum Zymogen Activation Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Platelet Alpha Granule Lumen Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex Protein C Inhibitor-PLAT Complex Serine-type Endopeptidase Inhibitor Activity Endopeptidase Activity Plasma Kallikrein-kinin Cascade Factor XII Activation Regulation Of Glucose Metabolic Process Seminal Clot Liquefaction Proteolysis Insulin-like Growth Factor Binding Protein Complex Platelet Dense Tubular Network Serine-type Peptidase Activity Regulation Of Wound Healing Positive Regulation Of Fibrinolysis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Protein Tyrosine Phosphatase Activator Activity Insulin-like Growth Factor Ternary Complex Acrosin Binding Heparin Binding Regulation Of CAMP-dependent Protein Kinase Activity Regulation Of Response To Wounding Epithelial Cell Proliferation Protein Processing Regulation Of Protein Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?