FDFT1 and TMEM43

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		FDFT1	TMEM43
Gene Name		farnesyl-diphosphate farnesyltransferase 1	transmembrane protein 43
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Integral Component Of Nuclear Inner Membrane Endoplasmic Reticulum Lumen Golgi Apparatus
	Molecular Function	Farnesyl-diphosphate Farnesyltransferase Activity Oxidoreductase Activity Squalene Synthase Activity	Protein Binding Protein Self-association
	Biological Process	Steroid Biosynthetic Process Cholesterol Biosynthetic Process Isoprenoid Biosynthetic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Farnesyl Diphosphate Metabolic Process Oxidation-reduction Process	Nuclear Membrane Organization
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) PPARA activates gene expression Cholesterol biosynthesis Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS		Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Non-alcoholic fatty liver disease histology (other) ( 20708005)
Protein-Protein Interactions		6 interactors: ANXA5 ARL6IP1 FAM101A RUVBL2 SHPRH TMEM43	2 interactors: FDFT1 SIAH1
Entrez ID		2222	79188
HPRD ID		01694	15541
Ensembl ID		ENSG00000079459	ENSG00000170876
Uniprot IDs		B4DT56 B4DWP0 B7Z1J3 P37268 Q6IAX1	Q9BTV4
PDB IDs		1EZF 3ASX 3LEE 3Q2Z 3Q30 3V66 3VJ8 3VJ9 3VJA 3VJB 3VJC
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Estrogen Receptor Binding Transcriptional Activation By Promoter-enhancer Looping Nuclear Membrane Organization Establishment Of Protein Localization To Chromatin DNA Conformation Change Negative Regulation Of Receptor Binding Protein Localization To Chromatin Histone H2A Acetylation	Farnesyl Diphosphate Metabolic Process
Tagcloud ?		abca1 biosynthesis brains cassette cholesterol debated extensively fdps genetically idi1 ldr lipids microarray mvd mvk notably nsdhl oligomeric oligomers plaques principal qpcr sc4mol steroid steroids toxic unexpected unresolved verified	arrhythmias arrhythmogenic arvc cardiomyopathy compensated confer definite desmosomal discrepancy dsc2 dsg2 dsp familial fibrofatty fulfilled genetics helps jup missense myocardium penetrance pkp2 poison relatives spanish stop sudden truncating ventricular
Tagcloud (Difference) ?		abca1 biosynthesis brains cassette cholesterol debated extensively fdps genetically idi1 ldr lipids microarray mvd mvk notably nsdhl oligomeric oligomers plaques principal qpcr sc4mol steroid steroids toxic unexpected unresolved verified	arrhythmias arrhythmogenic arvc cardiomyopathy compensated confer definite desmosomal discrepancy dsc2 dsg2 dsp familial fibrofatty fulfilled genetics helps jup missense myocardium penetrance pkp2 poison relatives spanish stop sudden truncating ventricular
Tagcloud (Intersection) ?