FDFT1 and ARL6IP1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		FDFT1	ARL6IP1
Gene Name		farnesyl-diphosphate farnesyltransferase 1	ADP-ribosylation factor-like 6 interacting protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Sec61 Translocon Complex Cytosol Membrane Integral Component Of Membrane
	Molecular Function	Farnesyl-diphosphate Farnesyltransferase Activity Oxidoreductase Activity Squalene Synthase Activity	Protein Binding
	Biological Process	Steroid Biosynthetic Process Cholesterol Biosynthetic Process Isoprenoid Biosynthetic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Farnesyl Diphosphate Metabolic Process Oxidation-reduction Process	Cotranslational Protein Targeting To Membrane
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) PPARA activates gene expression Cholesterol biosynthesis Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS		Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Non-alcoholic fatty liver disease histology (other) ( 20708005)
Protein-Protein Interactions		6 interactors: ANXA5 ARL6IP1 FAM101A RUVBL2 SHPRH TMEM43	40 interactors: ACSF2 ARL4D ARL6 C12orf10 COL4A3BP DIABLO FAM134C FBXW7 FDFT1 FXR2 GAD2 GOLPH3 GORASP2 HGS HMGCL INPP5K MTERF3 NAPB NDRG4 NUDT3 PAM16 PBX3 RAB33A RTN4 SENP2 SHMT2 SNX1 SNX10 SNX11 SNX12 SNX15 SNX3 SNX4 SPG21 SUCLA2 TFAM TUFM WIPI2 ZFYVE21 ZNF391
Entrez ID		2222	23204
HPRD ID		01694	09641
Ensembl ID		ENSG00000079459	ENSG00000170540
Uniprot IDs		B4DT56 B4DWP0 B7Z1J3 P37268 Q6IAX1	B7Z6S5 F5GXP4 Q15041
PDB IDs		1EZF 3ASX 3LEE 3Q2Z 3Q30 3V66 3VJ8 3VJ9 3VJA 3VJB 3VJC
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Estrogen Receptor Binding Transcriptional Activation By Promoter-enhancer Looping Nuclear Membrane Organization Establishment Of Protein Localization To Chromatin DNA Conformation Change Negative Regulation Of Receptor Binding Protein Localization To Chromatin Histone H2A Acetylation	Protein Transport Establishment Of Protein Localization Protein Localization Cellular Localization Vesicle Organization Establishment Of Localization In Cell Intracellular Transport Organelle Organization Cellular Protein Localization Intracellular Protein Transport Negative Regulation Of Early Endosome To Late Endosome Transport Mitochondrion Organization Regulation Of DNA Endoreduplication Succinate Metabolic Process Regulation Of Early Endosome To Late Endosome Transport Transport Protein Localization To Cilium Regulation Of Protein Catabolic Process Membrane Invagination Endomembrane System Organization Negative Regulation Of Intracellular Transport Cell Projection Assembly Protein Localization To Organelle Vesicle-mediated Transport Negative Regulation Of SREBP Signaling Pathway Succinyl-CoA Pathway Diphosphoinositol Polyphosphate Catabolic Process Posterior Compartment Specification Anterior Compartment Pattern Formation Positive Regulation Of Renal Water Transport Diadenosine Polyphosphate Catabolic Process Intralumenal Vesicle Formation Membrane Organization Localization Within Membrane Protein Localization To Membrane Endoplasmic Reticulum Organization Regulation Of Vesicle-mediated Transport Inositol Phosphate Metabolic Process Negative Regulation Of Protein Transport Lamellipodium Organization Alcohol Catabolic Process Glutamate Decarboxylation To Succinate Negative Regulation Of Triglyceride Biosynthetic Process ER To Golgi Ceramide Transport Uroporphyrinogen III Biosynthetic Process Cell Adhesion Molecule Production Intermembrane Transport Endosomal Transport Protein Targeting Biosynthetic Process
Tagcloud ?		abca1 biosynthesis brains cassette cholesterol debated extensively fdps genetically idi1 ldr lipids microarray mvd mvk notably nsdhl oligomeric oligomers plaques principal qpcr sc4mol steroid steroids toxic unexpected unresolved verified	1a 2b 3c 4c cisternae elaborate elucidated envelope er exogenously harboring homology interconnected localizes organelle potency reticulon reticulons shaped shaping sheet sheets suppress suppresses tmem33 transmembrane tubular tubulation tubules
Tagcloud (Difference) ?		abca1 biosynthesis brains cassette cholesterol debated extensively fdps genetically idi1 ldr lipids microarray mvd mvk notably nsdhl oligomeric oligomers plaques principal qpcr sc4mol steroid steroids toxic unexpected unresolved verified	1a 2b 3c 4c cisternae elaborate elucidated envelope er exogenously harboring homology interconnected localizes organelle potency reticulon reticulons shaped shaping sheet sheets suppress suppresses tmem33 transmembrane tubular tubulation tubules
Tagcloud (Intersection) ?