FDFT1 and PANX1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FDFT1	PANX1
Description		farnesyl-diphosphate farnesyltransferase 1	pannexin 1
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Gap Junction Membrane Bleb Protein-containing Complex
	Molecular Function	Catalytic Activity Protein Binding Transferase Activity Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups Metal Ion Binding Squalene Synthase [NAD(P)H] Activity	Protease Binding Actin Binding Signaling Receptor Binding Structural Molecule Activity Gap Junction Channel Activity Monoatomic Anion Channel Activity Calcium Channel Activity ATP Transmembrane Transporter Activity Protein Binding Channel Activity Wide Pore Channel Activity Leak Channel Activity Identical Protein Binding Transmembrane Transporter Binding Protein-containing Complex Binding Actin Filament Binding Gap Junction Hemi-channel Activity Scaffold Protein Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Lipid Biosynthetic Process Sterol Biosynthetic Process Farnesyl Diphosphate Metabolic Process	Response To Ischemia Monoatomic Ion Transport Monoatomic Cation Transport Calcium Ion Transport Cell-cell Signaling ATP Transport Cell Differentiation Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Response To ATP Monoatomic Ion Transmembrane Transport Oogenesis Positive Regulation Of Macrophage Cytokine Production Calcium Ion Transmembrane Transport Monoatomic Anion Transmembrane Transport
Pathways		Cholesterol biosynthesis PPARA activates gene expression Activation of gene expression by SREBF (SREBP)	Electric Transmission Across Gap Junctions The NLRP3 inflammasome High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
Drugs		TAK-475	Probenecid
Diseases
GWAS		A body shape index ( 34021172) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399) Ejection fraction in Tripanosoma cruzi seropositivity ( 24324551) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) Heschl's gyrus morphology ( 25130324) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Non-alcoholic fatty liver disease histology (other) ( 20708005) Platelet count ( 32888494) Polycystic ovary syndrome ( 26284813) Processed meat consumption ( 32066663) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Alanine aminotransferase levels ( 33339817 33547301 34315874) Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 29403010 33339817 33547301 34315874) Autoimmune thyroid disease ( 32581359) Liver enzyme levels (alanine transaminase) ( 33972514) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		25 interacting genes: ANXA5 AQP6 ARL13B ARL6IP1 CD74 CD79A CLN5 CREB3 ELOVL4 FAM209A GJA8 GPR152 ITGB5 JAGN1 LMNA NCAPH2 PANX1 RFLNA RUVBL2 SHPRH SLC10A1 SLC35H1 TLCD4 TMEM43 TMX2	16 interacting genes: APOA2 APOL2 AQP2 BCL2L2 BUD31 CFHR5 CLCA4 FAXDC2 FDFT1 GNAS P2RX7 SLC38A7 TMEM229B TNF VAMP5 WFDC2
Entrez ID		2222	24145
HPRD ID		01694	10526
Ensembl ID		ENSG00000079459	ENSG00000110218
Uniprot IDs		A0A1W2PQ47 B4DND3 B4DWP0 B7Z9R8 P37268 Q6IAX1	Q96RD7
PDB IDs		1EZF 3ASX 3LEE 3Q2Z 3Q30 3V66 3VJ8 3VJ9 3VJA 3VJB 3VJC 3WC9 3WCD 3WCF 3WCH 3WCI 3WCJ 3WCL 3WCM 3WEF 3WEG 3WEH 3WEI 3WEJ 3WEK 3WSA 6PYJ 6PYV 6PYW 6PZ5 8WTQ 8WTR	6LTN 6LTO 6M02 6M66 6M67 6M68 6V6D 6WBF 6WBG 6WBI 6WBK 6WBL 6WBM 6WBN 7DWB 7F8J 7F8N 7F8O 7WSV 8GTS 8GTT 8GYO
Enriched GO Terms of Interacting Partners?		Membrane Monoatomic Anion Channel Activity Endoplasmic Reticulum Endoplasmic Reticulum Membrane Identical Protein Binding	Sterol Metabolic Process Channel Activity High-density Lipoprotein Particle Binding Steroid Metabolic Process Cholesterol Metabolic Process Regulation Of Cytokine Production Involved In Immune Response Negative Regulation Of Lipid Catabolic Process Renal Water Homeostasis Disordered Domain Specific Binding Extrinsic Apoptotic Signaling Pathway Multicellular Organismal-level Water Homeostasis Lipoprotein Metabolic Process Regulation Of Production Of Molecular Mediator Of Immune Response Negative Regulation Of Cytokine Production Involved In Immune Response Sterol Biosynthetic Process Squalene Synthase [NAD(P)H] Activity Response To Fluid Shear Stress Response To Bacterium Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Response To Gram-negative Bacterium Negative Regulation Of Branching Involved In Lung Morphogenesis L-asparagine:sodium Symporter Activity L-glutamine:sodium Symporter Activity Positive Regulation Of Phagocytosis Peptidyl-methionine Modification Regulation Of Lipid Catabolic Process Cellular Response To Amyloid-beta Alcohol Metabolic Process Extracellular Region High-density Lipoprotein Particle Receptor Binding Positive Regulation Of Catabolic Process Response To Amyloid-beta Lipid Biosynthetic Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Interleukin-8 Production Negative Regulation Of Cholesterol Import Lumenal Side Of Membrane Response To Stress Cellular Response To Mercury Ion Cellular Response To Water Deprivation Multicellular Organismal-level Chemical Homeostasis Glycerol Transmembrane Transporter Activity Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mu-type Opioid Receptor Binding Regulation Of Protein Secretion Positive Regulation Of Bleb Assembly Positive Regulation Of Interleukin-1 Production Regulation Of Amine Transport
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