SERPIND1 and CTSG

Number of citations of the paper that reports this interaction (PubMedID 2318847)
0

Data Source:
HPRD (in vitro)

		SERPIND1	CTSG
Description		serpin family D member 1	cathepsin G
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Cytosol Plasma Membrane Cytoplasmic Stress Granule Membrane Secretory Granule Extracellular Matrix Azurophil Granule Lumen Extracellular Exosome
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Peptidase Inhibitor Activity	Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Receptor Ligand Activity Caspase Binding
	Biological Process	Chemotaxis Blood Coagulation Hemostasis	Angiotensin Maturation Monocyte Chemotaxis Protein Phosphorylation Proteolysis Chemotaxis Immune Response Protein Processing Cytokine-mediated Signaling Pathway Antibacterial Humoral Response Extracellular Matrix Disassembly Platelet Activation Response To Lipopolysaccharide Purinergic Nucleotide Receptor Signaling Pathway Neutrophil Activation Defense Response To Bacterium Positive Regulation Of Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Negative Regulation Of T Cell Activation Protein Maturation Neutrophil-mediated Killing Of Gram-positive Bacterium Cellular Response To Lipopolysaccharide Biofilm Matrix Disassembly Positive Regulation Of Platelet Aggregation
Pathways		Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-1 processing Neutrophil degranulation Antimicrobial peptides Suppression of apoptosis Purinergic signaling in leishmaniasis infection
Drugs		Ardeparin Zinc Sulodexide Copper Bemiparin Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Bis-Napthyl Beta-Ketophosphonic Acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid
Diseases		Inherited thrombophilia
GWAS			Congenital heart disease (maternal effect) ( 28468790) Conotruncal heart defects (maternal effects) ( 28468790)
Interacting Genes		5 interacting genes: APP CFTR CTSG ELANE F2	30 interacting genes: AGT C3 CAMP CASP7 CXCL12 CXCR4 CYSRT1 ERBIN F2R F2RL1 F2RL2 F5 GP1BA IGFBP3 KNG1 KRT31 LRP1 NOTCH2NLA PARP1 PICK1 PPBP SDC1 SELPLG SERPINA1 SERPINA3 SERPINB13 SERPINB4 SERPIND1 THBS1 VCAM1
Entrez ID		3053	1511
HPRD ID		00795	00289
Ensembl ID		ENSG00000099937	ENSG00000100448
Uniprot IDs		P05546 Q8IVC0	P08311
PDB IDs		1JMJ 1JMO 2NAT 2NCU 2NCV 2NCW 6J12 6KBO 6KBV	1AU8 1CGH 1KYN 1T32 6VTM 7H6G 7H6H 8D4S 8D4V 8D7I 8D7K 8G24 8G25 8G26 9ASX 9ATK
Enriched GO Terms of Interacting Partners?		Neutrophil-mediated Killing Of Bacterium Neutrophil Mediated Immunity Heparin Binding Killing By Host Of Symbiont Cells Biological Process Involved In Interaction With Symbiont Defense Response To Fungus Response To Fungus Neutrophil-mediated Killing Of Gram-negative Bacterium Leukocyte Mediated Cytotoxicity Immune Effector Process Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Receptor Ligand Activity Serine-type Peptidase Activity Killing Of Cells Of Another Organism Intracellular Chemical Homeostasis Leukocyte Mediated Immunity Serine-type Endopeptidase Activity Response To Yeast Antimicrobial Humoral Response Cellular Homeostasis Cell Killing Defense Response To Symbiont Defense Response To Other Organism Chemical Homeostasis Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Protein Transport Humoral Immune Response Regulation Of Monoatomic Ion Transmembrane Transport Defense Response To Bacterium Ligand-gated Ion Channel Signaling Pathway Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Extracellular Matrix Disassembly Response To Other Organism Regulation Of Platelet Activation Negative Regulation Of Multicellular Organismal Process Cellular Response To CAMP Immune Response Regulation Of Monoatomic Ion Transport Inorganic Ion Homeostasis Antibacterial Humoral Response Response To Bacterium Acute Inflammatory Response Homeostatic Process Regulation Of Multicellular Organismal Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	Coagulation Blood Coagulation Hemostasis Thrombin-activated Receptor Activity Extracellular Space Inflammatory Response Regulation Of Body Fluid Levels Extracellular Region Platelet Alpha Granule Lumen Thrombin-activated Receptor Signaling Pathway Serine-type Endopeptidase Inhibitor Activity Endopeptidase Inhibitor Activity Defense Response Peptidase Inhibitor Activity Circulatory System Process Extracellular Exosome Regulation Of Blood Coagulation Regulation Of Hemostasis Regulation Of Biological Quality Positive Regulation Of Programmed Cell Death Signaling Receptor Binding Regulation Of Secretion By Cell Chronic Inflammatory Response Endoplasmic Reticulum Lumen Regulation Of Secretion Response To External Biotic Stimulus Protease Binding Cell Activation Positive Regulation Of Multicellular Organismal Process Killing Of Cells Of Another Organism Leukocyte Migration Proteinase-activated Receptor Activity Response To Cytokine Regulation Of Wound Healing Regulation Of Programmed Cell Death Response To Peptide Platelet Alpha Granule Positive Regulation Of Cell Communication Positive Regulation Of Signaling Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure G Protein-coupled Receptor Signaling Pathway Vascular Process In Circulatory System Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Vessel Diameter Maintenance Regulation Of Tube Size Cellular Response To Cytokine Stimulus Immune System Process Regulation Of Renin Secretion Into Blood Stream Regulation Of Transport Positive Regulation Of Transport
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