HBQ1 and AHCYL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HBQ1	AHCYL1
Description		hemoglobin subunit theta 1	adenosylhomocysteinase like 1
Image		No pdb structure
GO Annotations	Cellular Component	Hemoglobin Complex Haptoglobin-hemoglobin Complex	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Apical Plasma Membrane Intracellular Membrane-bounded Organelle Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Extracellular Exosome
	Molecular Function	Oxygen Carrier Activity Iron Ion Binding Protein Binding Oxygen Binding Heme Binding Metal Ion Binding	RNA Binding Adenosylhomocysteinase Activity Protein Binding Enzyme Regulator Activity Identical Protein Binding
	Biological Process	Oxygen Transport Erythrocyte Development	Protein Export From Nucleus One-carbon Metabolic Process Apoptotic Process Positive Regulation Of Sodium Ion Transport Regulation Of MRNA 3'-end Processing Regulation Of Monoatomic Ion Transmembrane Transporter Activity S-adenosylmethionine Cycle Angiotensin-activated Signaling Pathway Epithelial Fluid Transport Regulation Of Monoatomic Anion Transport Response To Calcium Ion Mitochondrion-endoplasmic Reticulum Membrane Tethering
Pathways			PLC beta mediated events DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
GWAS		Hemoglobin ( 32888494) Hemoglobin levels ( 26366553 32327693) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 27863252 32888494) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)	Height ( 31562340)
Interacting Genes		10 interacting genes: AHCYL1 HBA1 HBA2 HBB HBD HBE1 HBG2 HBZ NTAQ1 RFESD	25 interacting genes: BID BTG3 CDKN2C CFTR DACH1 GEM HBQ1 HGS HSPA6 ITPR1 LRRK2 MEOX2 MFHAS1 PLEKHG5 PPL PRDM6 PSMD9 RNF6 SLC23A1 SOX30 SRPK1 SRPK2 SUMO2 UACA ZNF165
Entrez ID		3049	10768
HPRD ID		00791	07613
Ensembl ID		ENSG00000086506	ENSG00000168710
Uniprot IDs		A0A1K0GUV5 P09105	A0A024R0A8 O43865
PDB IDs			3MTG
Enriched GO Terms of Interacting Partners?		Haptoglobin-hemoglobin Complex Hemoglobin Complex Oxygen Carrier Activity Carbon Dioxide Transport Oxygen Transport One-carbon Compound Transport Oxygen Binding Erythrocyte Development Myeloid Cell Development Heme Binding Hemoglobin Alpha Binding Hemopoiesis Blood Microparticle Haptoglobin Binding Nitric Oxide Transport Cell Development Endocytic Vesicle Lumen Hydrogen Peroxide Catabolic Process Peroxidase Activity Hydrogen Peroxide Metabolic Process Cellular Oxidant Detoxification Reactive Oxygen Species Metabolic Process Response To Hydrogen Peroxide Cellular Detoxification Iron Ion Binding Response To Reactive Oxygen Species Metal Ion Binding Cellular Developmental Process Protein-N-terminal Glutamine Amidohydrolase Activity G Protein-coupled Receptor Binding Response To Oxidative Stress Adenosylhomocysteinase Activity Protein-N-terminal Asparagine Amidohydrolase Activity S-adenosylmethionine Cycle Cytosol Hemoglobin Binding Inflammatory Response Extracellular Exosome Mitochondrion-endoplasmic Reticulum Membrane Tethering Regulation Of MRNA 3'-end Processing S-adenosylmethionine Metabolic Process Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Developmental Process Erythrocyte Maturation Angiotensin-activated Signaling Pathway One-carbon Metabolic Process Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site 2 Iron, 2 Sulfur Cluster Binding
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