HBQ1 and HBG2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		HBQ1	HBG2
Name		hemoglobin subunit theta 1	hemoglobin subunit gamma 2
Structure		No pdb structure
GO Annotations	Cellular Component	Hemoglobin Complex Haptoglobin-hemoglobin Complex	Cytosol Hemoglobin Complex Haptoglobin-hemoglobin Complex Blood Microparticle
	Molecular Function	Oxygen Carrier Activity Iron Ion Binding Protein Binding Oxygen Binding Heme Binding Metal Ion Binding	Oxygen Carrier Activity Protein Binding Oxygen Binding Heme Binding Hemoglobin Alpha Binding Metal Ion Binding
	Biological Process	Oxygen Transport Erythrocyte Development	Carbon Dioxide Transport Oxygen Transport Erythrocyte Development
Pathways		None	Factors involved in megakaryocyte development and platelet production
GWAS		Hemoglobin ( 32888494 ) Hemoglobin levels ( 26366553 32327693 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular hemoglobin concentration ( 27863252 32888494 ) Mean corpuscular volume ( 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Red blood cell count ( 27863252 32888494 ) Red cell distribution width ( 32888494 ) Reticulocyte fraction of red cells ( 27863252 32888494 )	Beta thalassemia/hemoglobin E disease ( 20183929 ) Hemoglobin ( 28548082 ) Hemoglobin levels ( 26366553 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Logical memory (delayed recall) in normal cognition ( 29274321 ) Logical memory (immediate recall) in normal cognition ( 29274321 ) Malaria ( 31844061 ) Malate levels ( 31560688 ) Mean corpuscular hemoglobin concentration ( 28453575 32888494 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Red blood cell count ( 32888494 ) Red cell distribution width ( 27863252 32888494 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 )
Interacting Genes		10 interacting genes: AHCYL1 HBA1 HBA2 HBB HBD HBE1 HBG2 HBZ NTAQ1 RFESD	11 interacting genes: APP CYB5R3 HBA1 HBA2 HBB HBM HBQ1 HBZ RPSA SMAD5 XPNPEP1
Entrez ID		3049	3048
HPRD ID		00791	00792
Ensembl ID		ENSG00000086506	ENSG00000196565
Uniprot IDs		A0A1K0GUV5 P09105	D9YZU9 P69892
PDB IDs		Not available	1FDH 4MQJ 4MQK 7QU4
GO Terms Enriched among Interactors		Haptoglobin-hemoglobin Complex Hemoglobin Complex Oxygen Carrier Activity Carbon Dioxide Transport Oxygen Transport One-carbon Compound Transport Oxygen Binding Erythrocyte Development Myeloid Cell Development Heme Binding Hemoglobin Alpha Binding Hemopoiesis Blood Microparticle Haptoglobin Binding Nitric Oxide Transport Cell Development Endocytic Vesicle Lumen Hydrogen Peroxide Catabolic Process Peroxidase Activity Hydrogen Peroxide Metabolic Process Cellular Oxidant Detoxification Reactive Oxygen Species Metabolic Process Response To Hydrogen Peroxide Cellular Detoxification Iron Ion Binding Response To Reactive Oxygen Species Metal Ion Binding Cellular Developmental Process Protein-N-terminal Glutamine Amidohydrolase Activity G Protein-coupled Receptor Binding Response To Oxidative Stress Adenosylhomocysteinase Activity Protein-N-terminal Asparagine Amidohydrolase Activity S-adenosylmethionine Cycle Cytosol Hemoglobin Binding Inflammatory Response Extracellular Exosome Mitochondrion-endoplasmic Reticulum Membrane Tethering Regulation Of MRNA 3'-end Processing S-adenosylmethionine Metabolic Process Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Developmental Process Erythrocyte Maturation Angiotensin-activated Signaling Pathway One-carbon Metabolic Process Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site 2 Iron, 2 Sulfur Cluster Binding	Hemoglobin Complex Haptoglobin-hemoglobin Complex Oxygen Carrier Activity Oxygen Transport Myeloid Cell Development Oxygen Binding Erythrocyte Development Hemopoiesis Heme Binding Carbon Dioxide Transport Haptoglobin Binding One-carbon Compound Transport Nitric Oxide Transport Cell Development Endocytic Vesicle Lumen Hydrogen Peroxide Catabolic Process Iron Ion Binding Peroxidase Activity Hydrogen Peroxide Metabolic Process G Protein-coupled Receptor Binding Cellular Oxidant Detoxification Metal Ion Binding Reactive Oxygen Species Metabolic Process Response To Hydrogen Peroxide Cellular Detoxification Blood Microparticle Cellular Developmental Process Extracellular Exosome Response To Reactive Oxygen Species Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Defense Response Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Negative Regulation Of Fas Signaling Pathway Response To Oxidative Stress PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium