HBQ1 and HBZ

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		HBQ1	HBZ
Name		hemoglobin subunit theta 1	hemoglobin subunit zeta
Structure		No pdb structure
GO Annotations	Cellular Component	Hemoglobin Complex Haptoglobin-hemoglobin Complex	Hemoglobin Complex Haptoglobin-hemoglobin Complex Extracellular Exosome
	Molecular Function	Oxygen Carrier Activity Iron Ion Binding Protein Binding Oxygen Binding Heme Binding Metal Ion Binding	Oxygen Carrier Activity Iron Ion Binding Protein Binding Oxygen Binding Heme Binding Metal Ion Binding
	Biological Process	Oxygen Transport Erythrocyte Development	Negative Regulation Of Transcription By RNA Polymerase II Carbon Dioxide Transport Oxygen Transport Erythrocyte Maturation Erythrocyte Development
GWAS		Hemoglobin ( 32888494 ) Hemoglobin levels ( 26366553 32327693 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular hemoglobin concentration ( 27863252 32888494 ) Mean corpuscular volume ( 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Red blood cell count ( 27863252 32888494 ) Red cell distribution width ( 32888494 ) Reticulocyte fraction of red cells ( 27863252 32888494 )	Blood protein levels ( 30072576 ) Body mass index ( 26426971 ) Early cardiac repolarization ( 31600170 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 26366553 ) Mean corpuscular hemoglobin ( 27863252 29403010 32888494 ) Mean corpuscular hemoglobin concentration ( 29403010 ) Mean corpuscular volume ( 27863252 29403010 ) Red blood cell count ( 29403010 32888494 )
Interacting Genes		10 interacting genes: AHCYL1 HBA1 HBA2 HBB HBD HBE1 HBG2 HBZ NTAQ1 RFESD	30 interacting genes: APP CARD10 CCNDBP1 CYSRT1 DOCK8 FGFR3 GOLGA6L9 HBB HBD HBE1 HBG2 HBM HBQ1 HNRNPD HNRNPK IKBKG KHDRBS2 KHDRBS3 KRT31 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 MTUS2 NBPF19 NOTCH2NLA NTAQ1 RBMY1A1 SP1 UPF2
Entrez ID		3049	3050
HPRD ID		00791	00794
Ensembl ID		ENSG00000086506	ENSG00000130656
Uniprot IDs		A0A1K0GUV5 P09105	P02008
PDB IDs		Not available	1JEB 3W4U
GO Terms Enriched among Interactors		Haptoglobin-hemoglobin Complex Hemoglobin Complex Oxygen Carrier Activity Carbon Dioxide Transport Oxygen Transport One-carbon Compound Transport Oxygen Binding Erythrocyte Development Myeloid Cell Development Heme Binding Hemoglobin Alpha Binding Hemopoiesis Blood Microparticle Haptoglobin Binding Nitric Oxide Transport Cell Development Endocytic Vesicle Lumen Hydrogen Peroxide Catabolic Process Peroxidase Activity Hydrogen Peroxide Metabolic Process Cellular Oxidant Detoxification Reactive Oxygen Species Metabolic Process Response To Hydrogen Peroxide Cellular Detoxification Iron Ion Binding Response To Reactive Oxygen Species Metal Ion Binding Cellular Developmental Process Protein-N-terminal Glutamine Amidohydrolase Activity G Protein-coupled Receptor Binding Response To Oxidative Stress Adenosylhomocysteinase Activity Protein-N-terminal Asparagine Amidohydrolase Activity S-adenosylmethionine Cycle Cytosol Hemoglobin Binding Inflammatory Response Extracellular Exosome Mitochondrion-endoplasmic Reticulum Membrane Tethering Regulation Of MRNA 3'-end Processing S-adenosylmethionine Metabolic Process Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Developmental Process Erythrocyte Maturation Angiotensin-activated Signaling Pathway One-carbon Metabolic Process Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site 2 Iron, 2 Sulfur Cluster Binding	Hemoglobin Complex Haptoglobin-hemoglobin Complex Oxygen Carrier Activity Oxygen Transport Oxygen Binding Erythrocyte Development Myeloid Cell Development Hemoglobin Alpha Binding Carbon Dioxide Transport Hemopoiesis Heme Binding One-carbon Compound Transport Keratin Filament Intermediate Filament Regulation Of MRNA Splicing, Via Spliceosome Blood Microparticle MRNA Binding Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of RNA Splicing Cell Development Positive Regulation Of Amyloid Precursor Protein Catabolic Process Telomeric DNA Binding