HBQ1 and HBE1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		HBQ1	HBE1
Name		hemoglobin subunit theta 1	hemoglobin subunit epsilon 1
Structure		No pdb structure
GO Annotations	Cellular Component	Hemoglobin Complex Haptoglobin-hemoglobin Complex	Cytosol Hemoglobin Complex Haptoglobin-hemoglobin Complex Blood Microparticle
	Molecular Function	Oxygen Carrier Activity Iron Ion Binding Protein Binding Oxygen Binding Heme Binding Metal Ion Binding	Oxygen Carrier Activity Protein Binding Oxygen Binding Heme Binding Hemoglobin Alpha Binding Metal Ion Binding
	Biological Process	Oxygen Transport Erythrocyte Development	Carbon Dioxide Transport Oxygen Transport Erythrocyte Development
Pathways		None	Factors involved in megakaryocyte development and platelet production
GWAS		Hemoglobin ( 32888494 ) Hemoglobin levels ( 26366553 32327693 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular hemoglobin concentration ( 27863252 32888494 ) Mean corpuscular volume ( 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Red blood cell count ( 27863252 32888494 ) Red cell distribution width ( 32888494 ) Reticulocyte fraction of red cells ( 27863252 32888494 )	Beta thalassemia/hemoglobin E disease ( 20183929 ) Hematology traits ( 23263863 ) Hemoglobin ( 28548082 ) Hemoglobin levels ( 26366553 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Logical memory (delayed recall) in normal cognition ( 29274321 ) Logical memory (immediate recall) in normal cognition ( 29274321 ) Malaria ( 31844061 ) Mean corpuscular hemoglobin concentration ( 28453575 23263863 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Red cell distribution width ( 27863252 32888494 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 )
Novel Interactors		None recorded	1 novel interactors: NUP98
Interacting Genes		10 interacting genes: AHCYL1 HBA1 HBA2 HBB HBD HBE1 HBG2 HBZ NTAQ1 RFESD	5 interacting genes: HBA1 HBA2 HBM HBQ1 HBZ
Entrez ID		3049	3046
HPRD ID		00791	00788
Ensembl ID		ENSG00000086506	ENSG00000213931
Uniprot IDs		A0A1K0GUV5 P09105	D9YZU7 P02100
PDB IDs		Not available	1A9W
GO Terms Enriched among Interactors		Haptoglobin-hemoglobin Complex Hemoglobin Complex Oxygen Carrier Activity Carbon Dioxide Transport Oxygen Transport One-carbon Compound Transport Oxygen Binding Erythrocyte Development Myeloid Cell Development Heme Binding Hemoglobin Alpha Binding Hemopoiesis Blood Microparticle Haptoglobin Binding Nitric Oxide Transport Cell Development Endocytic Vesicle Lumen Hydrogen Peroxide Catabolic Process Peroxidase Activity Hydrogen Peroxide Metabolic Process Cellular Oxidant Detoxification Reactive Oxygen Species Metabolic Process Response To Hydrogen Peroxide Cellular Detoxification Iron Ion Binding Response To Reactive Oxygen Species Metal Ion Binding Cellular Developmental Process Protein-N-terminal Glutamine Amidohydrolase Activity G Protein-coupled Receptor Binding Response To Oxidative Stress Adenosylhomocysteinase Activity Protein-N-terminal Asparagine Amidohydrolase Activity S-adenosylmethionine Cycle Cytosol Hemoglobin Binding Inflammatory Response Extracellular Exosome Mitochondrion-endoplasmic Reticulum Membrane Tethering Regulation Of MRNA 3'-end Processing S-adenosylmethionine Metabolic Process Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Developmental Process Erythrocyte Maturation Angiotensin-activated Signaling Pathway One-carbon Metabolic Process Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site 2 Iron, 2 Sulfur Cluster Binding	Hemoglobin Complex Haptoglobin-hemoglobin Complex Oxygen Carrier Activity Oxygen Transport Oxygen Binding Erythrocyte Development Myeloid Cell Development Heme Binding Hemopoiesis Carbon Dioxide Transport Iron Ion Binding One-carbon Compound Transport Haptoglobin Binding Nitric Oxide Transport Cell Development Endocytic Vesicle Lumen Hydrogen Peroxide Catabolic Process Peroxidase Activity Hydrogen Peroxide Metabolic Process G Protein-coupled Receptor Binding Cellular Oxidant Detoxification Telomere Tethering At Nuclear Periphery Reactive Oxygen Species Metabolic Process Response To Hydrogen Peroxide Cellular Detoxification Cellular Developmental Process Blood Microparticle Post-transcriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Response To Reactive Oxygen Species Nuclear Pore Cytoplasmic Filaments Metal Ion Binding Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Telomere Localization Nuclear Pore Outer Ring Nuclear Pore Complex Assembly Nuclear Inclusion Body Nuclear Pore Nuclear Basket Nuclear Pore Organization Nuclear Periphery Response To Oxidative Stress Erythrocyte Maturation Pore Complex Assembly Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore Developmental Process Peptide Binding Positive Regulation Of MRNA Splicing, Via Spliceosome Inflammatory Response Positive Regulation Of RNA Splicing