SUZ12 and CDK19

Number of citations of the paper that reports this interaction (PubMedID 22668559)
0

Data Source:
BioGRID (pull down, pull down)

		SUZ12	CDK19
Description		SUZ12 polycomb repressive complex 2 subunit	cyclin dependent kinase 19
Image			No pdb structure
GO Annotations	Cellular Component	Sex Chromatin Nucleus Nucleoplasm Chromatin Silencing Complex Nucleolus RSC-type Complex Nuclear Body Protein-DNA Complex ESC/E(Z) Complex Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Perinuclear Region Of Cytoplasm CKM Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding Chromatin Binding RNA Binding Protein Binding Enzyme Activator Activity Zinc Ion Binding Chromatin DNA Binding Sequence-specific DNA Binding Metal Ion Binding Histone H3K9me2/3 Reader Activity LncRNA Binding Promoter-specific Chromatin Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Differentiation Oligodendrocyte Differentiation Random Inactivation Of X Chromosome Facultative Heterochromatin Formation	Positive Regulation Of Apoptotic Process Regulation Of Cell Cycle Cellular Response To Lipopolysaccharide
Pathways		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines SUMOylation of chromatin organization proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Regulation of PD-L1(CD274) transcription	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions
Drugs
Diseases
GWAS		High chromosomal aberration frequency (chromosome type) ( 31586183) Hip circumference adjusted for BMI ( 25673412)	General risk tolerance (MTAG) ( 30643258) Myeloperoxidase-DNA complexes ( 33717105) Zinc levels ( 26025379)
Interacting Genes		18 interacting genes: AEBP2 BCL11A CDK19 CDK8 CREB1 EZH2 H1-1 H3-4 LATS2 MED17 MED6 PAXIP1 PJA1 PRDM14 RNF10 UBC UBE2I WDR77	7 interacting genes: BCL6 EIF3F PRMT5 SMARCA4 SRSF7 SUZ12 WDR77
Entrez ID		23512	23097
HPRD ID		06949	07627
Ensembl ID		ENSG00000178691	ENSG00000155111
Uniprot IDs		J3QQW9 Q15022	B4DUB1 F6QTA4 I6W807 Q9BWU1
PDB IDs		4W2R 5HYN 5IJ7 5IJ8 5LS6 5WAI 5WAK 5WG6 6B3W 6C23 6C24 6NQ3 6WKR 7AT8 7KSO 7KSR 7KTP 7TD5 8EQV 8FYH 8T9G 8TAS 8TB9 8VMI 8VML 8VNV 8VNZ 9C8U 9DCH
Enriched GO Terms of Interacting Partners?		Nucleoplasm Protein Modification Process ESC/E(Z) Complex Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Protein Modification By Small Protein Conjugation Inner Cell Mass Cell Fate Commitment Regulation Of DNA-templated Transcription Initiation Protein-DNA Complex Assembly Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process CKM Complex Mediator Complex Regulation Of Developmental Process Post-translational Protein Modification Maintenance Of Cell Number Regulation Of RNA Metabolic Process Transcription Coregulator Activity DNA Replication-dependent Chromatin Assembly Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Protein Metabolic Process Transferase Complex Regulation Of Multicellular Organismal Process Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process G1 To G0 Transition Chromatin Organization Positive Regulation Of RNA Metabolic Process Protein Ubiquitination Chromatin DNA Binding Response To L-glutamate Regulation Of Cell Differentiation Regulation Of Transcription Elongation By RNA Polymerase II Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gliogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Chromosome Regulation Of DNA-templated Transcription Elongation Rhythmic Process Nucleosome Assembly	Negative Regulation Of Gene Expression, Epigenetic Epigenetic Regulation Of Gene Expression Heterochromatin Formation Negative Regulation Of Developmental Process Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome RSC-type Complex Methylosome Negative Regulation Of Gene Expression Regulation Of RNA Splicing Methyl-CpG Binding Positive Regulation Of MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly Chromatin Remodeling Negative Regulation Of RNA Metabolic Process Negative Regulation Of Cell Differentiation Positive Regulation Of RNA Splicing Spliceosomal SnRNP Assembly Transcription Corepressor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Regulation Of MRNA Metabolic Process Positive Regulation Of Cell Population Proliferation Negative Regulation Of Mitotic Cell Cycle DNA Replication P53 Binding Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Oocyte Axis Specification Chromatin DNA Binding Cysteine-type Deubiquitinase Activity Positive Regulation Of Cell Development Negative Regulation Of Mast Cell Cytokine Production Negative Regulation Of Plasma Cell Differentiation Peptidyl-arginine N-methylation Regulation Of RNA Metabolic Process Negative Regulation Of Isotype Switching To IgE Isotypes Regulation Of Mitotic Cell Cycle DNA Replication Isotype Switching To IgE Isotypes Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of T Cell Differentiation Chromatin Binding Regulation Of Mitotic Cell Cycle Intronic Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Glucose Mediated Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Histone Arginine N-methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Negative Regulation Of Biosynthetic Process Protein-containing Complex Assembly Cysteine-type Peptidase Activity
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