SUZ12 and MED17

Number of citations of the paper that reports this interaction (PMID 22668559)
1

Data Source:
BioGRID (pull down)

		SUZ12	MED17
Gene Name		SUZ12 polycomb repressive complex 2 subunit	mediator complex subunit 17
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Sex Chromatin Nucleus Nucleoplasm Nucleolus ESC/E(Z) Complex	Nucleus Nucleoplasm Transcription Factor Complex Membrane Mediator Complex
	Molecular Function	Chromatin Binding RNA Binding Protein Binding Methylated Histone Binding Histone Methyltransferase Activity Sequence-specific DNA Binding Metal Ion Binding	RNA Polymerase II Transcription Cofactor Activity Transcription Cofactor Activity Transcription Coactivator Activity Receptor Activity Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Positive Regulation Of Cell Proliferation Gene Expression Histone Methylation Histone Ubiquitination Regulation Of Gene Expression, Epigenetic Negative Regulation Of Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Stem Cell Maintenance Intracellular Steroid Hormone Receptor Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Oxidative Stress Induced Senescence Cellular Senescence Epigenetic regulation of gene expression PRC2 methylates histones and DNA	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: AEBP2 CDK19 CDK8 CREB1 CTCF EZH2 HIST1H1A HIST3H3 MED17 MED6 PAXIP1 PJA1 UBE2I USP7 WDR77	16 interactors: BCL6 CTDP1 ESR1 ESR2 HNF4A MED19 MED22 MED29 MED30 MED8 PPARGC1A SMARCA4 SREBF1 SUZ12 TP53 USP49
Entrez ID		23512	9440
HPRD ID		06949	04816
Ensembl ID		ENSG00000178691
Uniprot IDs		A8K1U9 J3QQW9 Q15022	Q9NVC6
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Chromatin Organization Organelle Organization Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Maintenance Of DNA Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Chromatin Modification Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Nitrogen Compound Metabolic Process Gene Expression Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Cellular Protein Modification Process Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA Metabolic Process DNA-templated Transcription, Initiation Negative Regulation Of Transcription, DNA-templated Regulation Of Histone Acetylation Positive Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Peptidyl-lysine Modification Regulation Of Histone Methylation Cellular Macromolecule Biosynthetic Process DNA Methylation Positive Regulation Of Histone H3-K36 Methylation Positive Regulation Of SUMO Transferase Activity Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Biosynthetic Process	Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription DNA-templated Transcription, Initiation Regulation Of Metabolic Process Negative Regulation Of Cell Growth Positive Regulation Of Histone Modification Positive Regulation Of Histone Deacetylation Intracellular Steroid Hormone Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Protein Deacetylation Negative Regulation Of Growth Regulation Of Histone Deacetylation Regulation Of Histone Modification Rhythmic Process Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cell Growth Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Deacetylation Cellular Response To Lipid Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Chromosome Organization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of Cellular Process Regulation Of Cell Proliferation Cellular Response To Hormone Stimulus Negative Regulation Of Androgen Receptor Signaling Pathway
Tagcloud ?		arise border cartilage cooperates craniofacial crest differentiate ectoderm eed embryogenesis expand extensively ezh2 fails h3k27 learnt migrate neural occupancy plate polycomb prc2 repressive slug snail2 specification trimethylation vertebrate xenopus	cdk colocalized concentrated connecting eukaryotes excision head helicase hinge holo interacted jaw module modules movable ner nutlin performs pol pulldown switching tbp tfiib tfiie tfiih uv xpb xpg
Tagcloud (Difference) ?		arise border cartilage cooperates craniofacial crest differentiate ectoderm eed embryogenesis expand extensively ezh2 fails h3k27 learnt migrate neural occupancy plate polycomb prc2 repressive slug snail2 specification trimethylation vertebrate xenopus	cdk colocalized concentrated connecting eukaryotes excision head helicase hinge holo interacted jaw module modules movable ner nutlin performs pol pulldown switching tbp tfiib tfiie tfiih uv xpb xpg
Tagcloud (Intersection) ?