NPPA and NR5A2

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NPPA	NR5A2
Gene Name		natriuretic peptide A	nuclear receptor subfamily 5, group A, member 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Mast Cell Granule Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Receptor Binding Neuropeptide Hormone Activity Peptide Hormone Receptor Binding Neuropeptide Receptor Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Phospholipid Binding Zinc Ion Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Response To Hypoxia Negative Regulation Of Systemic Arterial Blood Pressure CGMP Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Receptor Guanylyl Cyclase Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy Regulation Of Blood Pressure Positive Regulation Of Heart Rate Gene Expression Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Cell Growth Response To Insulin Response To Muscle Stretch Regulation Of Blood Vessel Size Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Positive Regulation Of Cardiac Muscle Contraction Cellular Response To Mechanical Stimulus Regulation Of High Voltage-gated Calcium Channel Activity Positive Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Generation Of L-type Calcium Current	Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Bile Acid Metabolic Process Embryo Development Gene Expression Intracellular Receptor Signaling Pathway Endocrine Pancreas Development Regulation Of Cell Proliferation Homeostatic Process Cholesterol Homeostasis Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Viral Genome Replication Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Amyloids Generic Transcription Pathway YAP1- and WWTR1 (TAZ)-stimulated gene expression
Drugs
Diseases
GWAS		Atrial fibrillation ( 19597492) Systolic blood pressure ( 19430483)	Pancreatic cancer ( 20101243)
Protein-Protein Interactions		12 interactors: EPB41 ESR1 HNF4A MAGEA12 MME NPR1 NPR2 NPR3 NR5A2 RORB UBQLN1 UBQLN4	19 interactors: ALB BCKDK COPS5 EDF1 FTH1 NCOA1 NCOA3 NPPA NR0B2 NRIP1 NSD1 PNRC1 PNRC2 POLR2D PROX1 RAD54L2 SMARCD3 SRC UBE2I
Entrez ID		4878	2494
HPRD ID		00164	06830
Ensembl ID		ENSG00000175206	ENSG00000116833
Uniprot IDs		P01160	B4E2P3 F1D8R9 O00482
PDB IDs		1ANP 1YK0 3N57	1YOK 1YUC 1ZDU 2A66 3PLZ 3TX7 4DOR 4DOS 4IS8
Enriched GO Terms of Interacting Partners?		Steroid Hormone Mediated Signaling Pathway Blood Circulation Hormone-mediated Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Regulation Of Blood Pressure Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Receptor Guanylyl Cyclase Signaling Pathway Positive Regulation Of Urine Volume Cellular Response To Organic Cyclic Compound CGMP Biosynthetic Process Positive Regulation Of Nitric-oxide Synthase Activity Cellular Response To Lipid Positive Regulation Of Monooxygenase Activity Response To Steroid Hormone CGMP Metabolic Process Cellular Response To Organic Substance Cellular Response To Hormone Stimulus Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Oxidoreductase Activity Cyclic Purine Nucleotide Metabolic Process Negative Regulation Of Smooth Muscle Cell Proliferation Cyclic Nucleotide Biosynthetic Process Endocrine Pancreas Development Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Cell Proliferation Response To Lipid Cyclic Nucleotide Metabolic Process Regulation Of Oxidoreductase Activity Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Response To Organic Cyclic Compound Response To Organic Substance Cellular Response To Stimulus Response To Hormone Pancreas Development Renal System Process Regulation Of Smooth Muscle Cell Proliferation Body Fluid Secretion Lipid Homeostasis Cellular Response To UV-A Negative Regulation Of Oocyte Maturation Prostate Epithelial Cord Elongation System Development Organ Development Positive Regulation Of Cholesterol Homeostasis Regulation Of Metabolic Process Negative Regulation Of Oocyte Development Regulation Of Growth Hormone Receptor Signaling Pathway	Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Gene Expression Regulation Of Nucleic Acid-templated Transcription Cellular Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Intracellular Steroid Hormone Receptor Signaling Pathway Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Androgen Receptor Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Metabolic Process Cellular Metabolic Process Metabolic Process Regulation Of Cellular Process Transcription From RNA Polymerase II Promoter Peptidyl-lysine Modification Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Labyrinthine Layer Morphogenesis Positive Regulation Of Organelle Assembly Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryonic Placenta Morphogenesis Gland Morphogenesis Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Response To Nutrient Levels Mammary Gland Development Anatomical Structure Development Negative Regulation Of Gene Expression Response To Extracellular Stimulus Negative Regulation Of Biosynthetic Process
Tagcloud ?		biventricle bv cardiomyogenic circuits combinatorial coordinately cpcs dimethylation dissect h3k27 h3k4 hampered hand1 hey hlhs hypoplastic ips maldevelopment malformations nkx2 notch1 pluripotency pluripotent reconstitute reprogrammed signatures sre tbx2 tnnt2	4f 6f boosts copyright dn endogenously epiblast episcs feeder impedes ipscs klf4 lrh1 mef mefs n2b27 oct4 pluripotency pluripotent primed rarg reprogram reprogramming reprograms reserved rights sox2 supplementing synthesised
Tagcloud (Difference) ?		biventricle bv cardiomyogenic circuits combinatorial coordinately cpcs dimethylation dissect h3k27 h3k4 hampered hand1 hey hlhs hypoplastic ips maldevelopment malformations nkx2 notch1 reconstitute reprogrammed signatures sre tbx2 tnnt2	4f 6f boosts copyright dn endogenously epiblast episcs feeder impedes ipscs klf4 lrh1 mef mefs n2b27 oct4 primed rarg reprogram reprogramming reprograms reserved rights sox2 supplementing synthesised
Tagcloud (Intersection) ?		pluripotency pluripotent