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NPPA and NPR1
Number of citations of the paper that reports this interaction (PubMedID
12547834
)
0
Data Source:
HPRD
(in vivo)
NPPA
NPR1
Description
natriuretic peptide A
natriuretic peptide receptor 1
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Cytoplasm
Brush Border
Protein-containing Complex
Mast Cell Granule
Cell Projection
Perikaryon
Perinuclear Region Of Cytoplasm
Glycinergic Synapse
Plasma Membrane
Membrane
Receptor Complex
ANPR-A Receptor Complex
Molecular Function
Signaling Receptor Binding
Hormone Activity
Neuropeptide Hormone Activity
Protein Binding
Guanylate Cyclase Activator Activity
Hormone Receptor Binding
Neuropeptide Receptor Binding
Nucleotide Binding
Peptide Receptor Activity
Guanylate Cyclase Activity
Protein Kinase Activity
ATP Binding
GTP Binding
G Protein-coupled Peptide Receptor Activity
Lyase Activity
Phosphorus-oxygen Lyase Activity
Natriuretic Peptide Receptor Activity
Peptide Hormone Binding
Hormone Binding
Biological Process
Response To Hypoxia
System Process
Negative Regulation Of Systemic Arterial Blood Pressure
Cardiac Conduction System Development
Aortic Valve Morphogenesis
CGMP Biosynthetic Process
Protein Folding
Receptor Guanylyl Cyclase Signaling Pathway
Neuropeptide Signaling Pathway
Female Pregnancy
Regulation Of Blood Pressure
Positive Regulation Of Heart Rate
Positive Regulation Of CGMP-mediated Signaling
Cardiac Muscle Hypertrophy In Response To Stress
CGMP-mediated Signaling
Negative Regulation Of Cell Growth
Response To Insulin
Response To Muscle Stretch
Sodium Ion Export Across Plasma Membrane
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Vasodilation
Regulation Of Vascular Permeability
Negative Regulation Of JUN Kinase Activity
Negative Regulation Of Blood Pressure
Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization
Positive Regulation Of Cardiac Muscle Contraction
Cell Growth Involved In Cardiac Muscle Cell Development
Cellular Response To Hydrogen Peroxide
Cellular Response To Mechanical Stimulus
Negative Regulation Of Canonical Wnt Signaling Pathway
Blood Vessel Diameter Maintenance
Synaptic Signaling Via Neuropeptide
Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel
Positive Regulation Of Potassium Ion Export Across Plasma Membrane
Negative Regulation Of Collecting Lymphatic Vessel Constriction
Cellular Response To Angiotensin
Response To 3-methylcholanthrene
CGMP Biosynthetic Process
Cell Surface Receptor Signaling Pathway
Receptor Guanylyl Cyclase Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Body Fluid Secretion
Blood Circulation
Regulation Of Blood Pressure
Cyclic Nucleotide Biosynthetic Process
Positive Regulation Of CGMP-mediated Signaling
Negative Regulation Of Angiogenesis
CGMP-mediated Signaling
Negative Regulation Of Cell Growth
Intracellular Signal Transduction
Positive Regulation Of Urine Volume
Positive Regulation Of Renal Sodium Excretion
Dopamine Metabolic Process
Regulation Of Vascular Permeability
Negative Regulation Of Smooth Muscle Cell Proliferation
Blood Vessel Diameter Maintenance
Pathways
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Physiological factors
Amyloid fiber formation
Physiological factors
Drugs
Nitroprusside
Nitroglycerin
Isosorbide dinitrate
Amyl Nitrite
Erythrityl tetranitrate
Nesiritide
Ularitide
Diseases
Atrial fibrillation
GWAS
Atrial fibrillation (
19597492
)
Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) (
29455858
)
Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Midregional pro atrial natriuretic peptide levels (
29237677
)
Psoriasis (
25854761
)
Pulse pressure (
30578418
)
Systolic blood pressure (
19430483
30578418
)
Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) (
29455858
)
Systolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Tuberculosis (
29036319
)
Mean arterial pressure (
27618448
)
Systolic blood pressure (
27618448
)
Interacting Genes
14 interacting genes:
EPB41
ESR1
HNF4A
HSF2BP
MAGEA12
MME
NPR1
NPR2
NPR3
NR5A2
RORB
UBQLN1
UBQLN2
UBQLN4
7 interacting genes:
ATF7IP
MTDH
NPPA
NPPB
NPPC
PRKG1
UBE2D2
Entrez ID
4878
4881
HPRD ID
00164
00165
Ensembl ID
ENSG00000175206
ENSG00000169418
Uniprot IDs
P01160
A0A140VJE6
P16066
PDB IDs
1ANP
1YK0
3N57
7BRH
7BRJ
7BRK
8TG9
9BCQ
8TG9
8TGA
9BCL
9BCN
9BCO
9BCP
9BCQ
9BCS
9BCV
Enriched GO Terms of Interacting Partners
?
Natriuretic Peptide Receptor Activity
Nuclear Receptor Activity
CGMP Biosynthetic Process
Hormone Binding
CGMP Metabolic Process
Cyclic Nucleotide Biosynthetic Process
Peptide Hormone Binding
Polyubiquitin Modification-dependent Protein Binding
Cyclic Purine Nucleotide Metabolic Process
Guanylate Cyclase Activity
Intracellular Receptor Signaling Pathway
Positive Regulation Of Urine Volume
Receptor Guanylyl Cyclase Signaling Pathway
Autophagosome
Rhythmic Process
Nucleobase-containing Compound Biosynthetic Process
Female Genitalia Development
Positive Regulation Of ERAD Pathway
Phosphorus-oxygen Lyase Activity
Regulation Of Urine Volume
Purine Ribonucleotide Biosynthetic Process
Regulation Of ERAD Pathway
Peptide Binding
Ribose Phosphate Biosynthetic Process
Protein-containing Complex
Ovulation Cycle Process
Sequence-specific DNA Binding
Transcription Coregulator Binding
Genitalia Development
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Regulation Of Blood Pressure
Purine Nucleotide Biosynthetic Process
Blood Circulation
G Protein-coupled Peptide Receptor Activity
Vacuole Organization
Blood Vessel Remodeling
Positive Regulation Of Response To Endoplasmic Reticulum Stress
Regulation Of Macroautophagy
Nucleotide Biosynthetic Process
Regulation Of Proteasomal Protein Catabolic Process
Developmental Process Involved In Reproduction
Organ Growth
Zygotic Genome Activation
Regulation Of Ornithine Metabolic Process
Neuropeptide Processing
ANPR-A Receptor Complex
Vestibulocochlear Nerve Maturation
Negative Regulation Of Store-operated Calcium Channel Activity
Purine-containing Compound Biosynthetic Process
Regulation Of Hormone Levels
Hormone Receptor Binding
CGMP-mediated Signaling
Guanylate Cyclase Activator Activity
Receptor Guanylyl Cyclase Signaling Pathway
CGMP Biosynthetic Process
CGMP Metabolic Process
Cyclic Nucleotide Biosynthetic Process
Blood Vessel Diameter Maintenance
Regulation Of Tube Size
Cyclic Purine Nucleotide Metabolic Process
Regulation Of Vascular Permeability
Vasodilation
Vascular Process In Circulatory System
Positive Regulation Of CGMP-mediated Signaling
Circulatory System Process
Cell Growth Involved In Cardiac Muscle Cell Development
Hormone Activity
Regulation Of CGMP-mediated Signaling
Purine Ribonucleotide Biosynthetic Process
Cardiac Conduction System Development
Bone Growth
Ribose Phosphate Biosynthetic Process
Purine Nucleotide Biosynthetic Process
Negative Regulation Of Systemic Arterial Blood Pressure
Nucleotide Biosynthetic Process
Protein Folding
Purine-containing Compound Biosynthetic Process
Protein-containing Complex
Nucleoside Phosphate Biosynthetic Process
Purine Ribonucleotide Metabolic Process
Negative Regulation Of Blood Pressure
Organ Growth
Ribonucleotide Metabolic Process
Intracellular Signaling Cassette
Ribose Phosphate Metabolic Process
Cardiac Muscle Tissue Development
Purine Nucleotide Metabolic Process
Developmental Growth
Negative Regulation Of Collecting Lymphatic Vessel Constriction
Signaling Receptor Binding
Diuretic Hormone Activity
Nucleotide Metabolic Process
Carbohydrate Derivative Biosynthetic Process
Neuropeptide Signaling Pathway
Neuropeptide Receptor Binding
Response To 3-methylcholanthrene
Purine-containing Compound Metabolic Process
Cumulus Cell Differentiation
C-di-GMP Signaling
Multicellular Organismal Locomotion
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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