NPPA and NPR3

Number of citations of the paper that reports this interaction (PubMedID 2169733)
0

Data Source:
HPRD (in vitro)

		NPPA	NPR3
Description		natriuretic peptide A	natriuretic peptide receptor 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Brush Border Protein-containing Complex Mast Cell Granule Cell Projection Perikaryon Perinuclear Region Of Cytoplasm Glycinergic Synapse	Plasma Membrane Membrane Protein-containing Complex Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Guanylate Cyclase Activator Activity Hormone Receptor Binding Neuropeptide Receptor Binding	Protein Binding G Protein-coupled Peptide Receptor Activity Natriuretic Peptide Receptor Activity Peptide Hormone Binding Chloride Ion Binding Peptide Binding Hormone Binding Protein Homodimerization Activity Receptor Decoy Activity
	Biological Process	Response To Hypoxia System Process Negative Regulation Of Systemic Arterial Blood Pressure Cardiac Conduction System Development Aortic Valve Morphogenesis CGMP Biosynthetic Process Protein Folding Receptor Guanylyl Cyclase Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy Regulation Of Blood Pressure Positive Regulation Of Heart Rate Positive Regulation Of CGMP-mediated Signaling Cardiac Muscle Hypertrophy In Response To Stress CGMP-mediated Signaling Negative Regulation Of Cell Growth Response To Insulin Response To Muscle Stretch Sodium Ion Export Across Plasma Membrane Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vasodilation Regulation Of Vascular Permeability Negative Regulation Of JUN Kinase Activity Negative Regulation Of Blood Pressure Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Positive Regulation Of Cardiac Muscle Contraction Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Hydrogen Peroxide Cellular Response To Mechanical Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Blood Vessel Diameter Maintenance Synaptic Signaling Via Neuropeptide Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Positive Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Collecting Lymphatic Vessel Constriction Cellular Response To Angiotensin Response To 3-methylcholanthrene	Skeletal System Development Angiogenesis Blood Vessel Remodeling Osteoclast Proliferation Response To Ischemia CGMP Biosynthetic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of Blood Pressure Regulation Of Osteoblast Proliferation Positive Regulation Of Urine Volume Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Relaxation Of Smooth Muscle
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors Amyloid fiber formation
Drugs			Nesiritide
Diseases		Atrial fibrillation
GWAS		Atrial fibrillation ( 19597492) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Midregional pro atrial natriuretic peptide levels ( 29237677) Psoriasis ( 25854761) Pulse pressure ( 30578418) Systolic blood pressure ( 19430483 30578418) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tuberculosis ( 29036319)	Appendicular lean mass ( 33097823) Blood pressure ( 21572416 21909110 24954895) Diastolic blood pressure ( 27618452 27841878 26390057 28739976 21909115) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340 28552196 28270201 19570815 23563607 19343178 20881960 25282103) Hip circumference adjusted for BMI ( 34021172 25673412) Hypertension ( 31879980 21909115) Mean arterial pressure ( 26390057 30487518 29403010) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Ovarian reserve ( 22116950) Pulse pressure ( 30578418 28739976 27841878) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Symptoms in placebo-treated COVID-19 outpatients at risk of severe disease (time to remission) ( 34035401) Systolic blood pressure ( 30578418 21909115 27618447 29403010 28739976 28135244 27841878 26390057 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		14 interacting genes: EPB41 ESR1 HNF4A HSF2BP MAGEA12 MME NPR1 NPR2 NPR3 NR5A2 RORB UBQLN1 UBQLN2 UBQLN4	3 interacting genes: NPPA NPPB NPPC
Entrez ID		4878	4883
HPRD ID		00164	00167
Ensembl ID		ENSG00000175206	ENSG00000113389
Uniprot IDs		P01160	A8K4A5 C9JK69 P17342 Q60I31
PDB IDs		1ANP 1YK0 3N57 7BRH 7BRJ 7BRK 8TG9 9BCQ	1JDN 1JDP 1YK0 1YK1
Enriched GO Terms of Interacting Partners?		Natriuretic Peptide Receptor Activity Nuclear Receptor Activity CGMP Biosynthetic Process Hormone Binding CGMP Metabolic Process Cyclic Nucleotide Biosynthetic Process Peptide Hormone Binding Polyubiquitin Modification-dependent Protein Binding Cyclic Purine Nucleotide Metabolic Process Guanylate Cyclase Activity Intracellular Receptor Signaling Pathway Positive Regulation Of Urine Volume Receptor Guanylyl Cyclase Signaling Pathway Autophagosome Rhythmic Process Nucleobase-containing Compound Biosynthetic Process Female Genitalia Development Positive Regulation Of ERAD Pathway Phosphorus-oxygen Lyase Activity Regulation Of Urine Volume Purine Ribonucleotide Biosynthetic Process Regulation Of ERAD Pathway Peptide Binding Ribose Phosphate Biosynthetic Process Protein-containing Complex Ovulation Cycle Process Sequence-specific DNA Binding Transcription Coregulator Binding Genitalia Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Blood Pressure Purine Nucleotide Biosynthetic Process Blood Circulation G Protein-coupled Peptide Receptor Activity Vacuole Organization Blood Vessel Remodeling Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Macroautophagy Nucleotide Biosynthetic Process Regulation Of Proteasomal Protein Catabolic Process Developmental Process Involved In Reproduction Organ Growth Zygotic Genome Activation Regulation Of Ornithine Metabolic Process Neuropeptide Processing ANPR-A Receptor Complex Vestibulocochlear Nerve Maturation Negative Regulation Of Store-operated Calcium Channel Activity Purine-containing Compound Biosynthetic Process Regulation Of Hormone Levels	Hormone Receptor Binding Guanylate Cyclase Activator Activity Receptor Guanylyl Cyclase Signaling Pathway CGMP Biosynthetic Process CGMP Metabolic Process Cyclic Nucleotide Biosynthetic Process CGMP-mediated Signaling Cyclic Purine Nucleotide Metabolic Process Positive Regulation Of CGMP-mediated Signaling Hormone Activity Regulation Of CGMP-mediated Signaling Purine Ribonucleotide Biosynthetic Process Blood Vessel Diameter Maintenance Cardiac Conduction System Development Regulation Of Tube Size Ribose Phosphate Biosynthetic Process Purine Nucleotide Biosynthetic Process Negative Regulation Of Systemic Arterial Blood Pressure Protein Folding Nucleotide Biosynthetic Process Purine-containing Compound Biosynthetic Process Vascular Process In Circulatory System Nucleoside Phosphate Biosynthetic Process Purine Ribonucleotide Metabolic Process Regulation Of Vascular Permeability Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Negative Regulation Of Blood Pressure Nuclear Receptor Binding Circulatory System Process Vasodilation Purine Nucleotide Metabolic Process Cardiac Muscle Tissue Development Signaling Receptor Binding Nucleotide Metabolic Process Negative Regulation Of Collecting Lymphatic Vessel Constriction Diuretic Hormone Activity Carbohydrate Derivative Biosynthetic Process Purine-containing Compound Metabolic Process Neuropeptide Signaling Pathway Organophosphate Biosynthetic Process Nucleoside Phosphate Metabolic Process Neuropeptide Receptor Binding Response To 3-methylcholanthrene Cumulus Cell Differentiation C-di-GMP Signaling Multicellular Organismal Locomotion Gastric Emptying Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Nucleobase-containing Small Molecule Metabolic Process
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