NPPA

Gene Name		natriuretic peptide A
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Mast Cell Granule Perinuclear Region Of Cytoplasm
	Molecular Function	Receptor Binding Neuropeptide Hormone Activity Peptide Hormone Receptor Binding Neuropeptide Receptor Binding
	Biological Process	Response To Hypoxia Negative Regulation Of Systemic Arterial Blood Pressure CGMP Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Receptor Guanylyl Cyclase Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy Regulation Of Blood Pressure Positive Regulation Of Heart Rate Gene Expression Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Cell Growth Response To Insulin Response To Muscle Stretch Regulation Of Blood Vessel Size Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Positive Regulation Of Cardiac Muscle Contraction Cellular Response To Mechanical Stimulus Regulation Of High Voltage-gated Calcium Channel Activity Positive Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Generation Of L-type Calcium Current
Pathways		Amyloids Generic Transcription Pathway YAP1- and WWTR1 (TAZ)-stimulated gene expression
Drugs
Diseases
GWAS		Atrial fibrillation ( 19597492) Systolic blood pressure ( 19430483)
Protein-protein Interactions		12 interactors: EPB41 ESR1 HNF4A MAGEA12 MME NPR1 NPR2 NPR3 NR5A2 RORB UBQLN1 UBQLN4
Entrez ID		4878
HPRD ID		00164
Ensembl ID		ENSG00000175206
Uniprot IDs		P01160
PDB IDs		1ANP 1YK0 3N57
Enriched GO Terms of Interacting Partners?		Steroid Hormone Mediated Signaling Pathway Blood Circulation Hormone-mediated Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Regulation Of Blood Pressure Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Receptor Guanylyl Cyclase Signaling Pathway Positive Regulation Of Urine Volume Cellular Response To Organic Cyclic Compound CGMP Biosynthetic Process Positive Regulation Of Nitric-oxide Synthase Activity Cellular Response To Lipid Positive Regulation Of Monooxygenase Activity Response To Steroid Hormone CGMP Metabolic Process Cellular Response To Organic Substance Cellular Response To Hormone Stimulus Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Oxidoreductase Activity Cyclic Purine Nucleotide Metabolic Process Negative Regulation Of Smooth Muscle Cell Proliferation Cyclic Nucleotide Biosynthetic Process Endocrine Pancreas Development Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Cell Proliferation Response To Lipid Cyclic Nucleotide Metabolic Process Regulation Of Oxidoreductase Activity Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Response To Organic Cyclic Compound Response To Organic Substance Cellular Response To Stimulus Response To Hormone Pancreas Development Renal System Process Regulation Of Smooth Muscle Cell Proliferation Body Fluid Secretion Lipid Homeostasis Cellular Response To UV-A Negative Regulation Of Oocyte Maturation Prostate Epithelial Cord Elongation System Development Organ Development Positive Regulation Of Cholesterol Homeostasis Regulation Of Metabolic Process Negative Regulation Of Oocyte Development Regulation Of Growth Hormone Receptor Signaling Pathway
Tagcloud ?		biventricle bv cardiomyogenic circuits combinatorial coordinately cpcs dimethylation dissect h3k27 h3k4 hampered hand1 hey hlhs hypoplastic ips maldevelopment malformations nkx2 notch1 pluripotency pluripotent reconstitute reprogrammed signatures sre tbx2 tnnt2