NPPA and MME

Number of citations of the paper that reports this interaction (PMID 2972276)
8

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		NPPA	MME
Gene Name		natriuretic peptide A	membrane metallo-endopeptidase
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Mast Cell Granule Perinuclear Region Of Cytoplasm	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Brush Border Focal Adhesion Synaptic Vesicle Integral Component Of Membrane Axon Dendrite Neuron Projection Terminus Synapse Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Neuropeptide Hormone Activity Peptide Hormone Receptor Binding Neuropeptide Receptor Binding	Endopeptidase Activity Metalloendopeptidase Activity Protein Binding Exopeptidase Activity Zinc Ion Binding Peptide Binding
	Biological Process	Response To Hypoxia Negative Regulation Of Systemic Arterial Blood Pressure CGMP Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Receptor Guanylyl Cyclase Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy Regulation Of Blood Pressure Positive Regulation Of Heart Rate Gene Expression Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Cell Growth Response To Insulin Response To Muscle Stretch Regulation Of Blood Vessel Size Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Positive Regulation Of Cardiac Muscle Contraction Cellular Response To Mechanical Stimulus Regulation Of High Voltage-gated Calcium Channel Activity Positive Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Generation Of L-type Calcium Current	Kidney Development Angiotensin Maturation Proteolysis Peptide Metabolic Process Sensory Perception Of Pain Cellular Protein Metabolic Process Creatinine Metabolic Process Beta-amyloid Metabolic Process Cellular Response To Cytokine Stimulus Cellular Response To UV-A Cellular Response To UV-B Replicative Senescence
Pathways		Amyloids Generic Transcription Pathway YAP1- and WWTR1 (TAZ)-stimulated gene expression	Peptide hormone metabolism Metabolism of Angiotensinogen to Angiotensins
Drugs			Candoxatril N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1\'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine Phosphoramidon N-(3-Phenyl-2-Sulfanylpropanoyl)Phenylalanylalanine [2(R,S)-2-Sulfanylheptanoyl]-Phe-Ala 2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM Thiorphan
Diseases
GWAS		Atrial fibrillation ( 19597492) Systolic blood pressure ( 19430483)
Protein-Protein Interactions		12 interactors: EPB41 ESR1 HNF4A MAGEA12 MME NPR1 NPR2 NPR3 NR5A2 RORB UBQLN1 UBQLN4	16 interactors: ADCYAP1 ADM AGT CSNK2A1 CSNK2B EDN1 EDN2 GAST LYN NDRG1 NPPA NPPC PIK3CB PIK3R1 SHC1 VIP
Entrez ID		4878	4311
HPRD ID		00164	00392
Ensembl ID		ENSG00000175206	ENSG00000196549
Uniprot IDs		P01160	P08473
PDB IDs		1ANP 1YK0 3N57	1DL9 1DMT 1QVD 1R1H 1R1I 1R1J 1Y8J 2QPJ 2YB9
Enriched GO Terms of Interacting Partners?		Steroid Hormone Mediated Signaling Pathway Blood Circulation Hormone-mediated Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Regulation Of Blood Pressure Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Receptor Guanylyl Cyclase Signaling Pathway Positive Regulation Of Urine Volume Cellular Response To Organic Cyclic Compound CGMP Biosynthetic Process Positive Regulation Of Nitric-oxide Synthase Activity Cellular Response To Lipid Positive Regulation Of Monooxygenase Activity Response To Steroid Hormone CGMP Metabolic Process Cellular Response To Organic Substance Cellular Response To Hormone Stimulus Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Oxidoreductase Activity Cyclic Purine Nucleotide Metabolic Process Negative Regulation Of Smooth Muscle Cell Proliferation Cyclic Nucleotide Biosynthetic Process Endocrine Pancreas Development Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Cell Proliferation Response To Lipid Cyclic Nucleotide Metabolic Process Regulation Of Oxidoreductase Activity Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Response To Organic Cyclic Compound Response To Organic Substance Cellular Response To Stimulus Response To Hormone Pancreas Development Renal System Process Regulation Of Smooth Muscle Cell Proliferation Body Fluid Secretion Lipid Homeostasis Cellular Response To UV-A Negative Regulation Of Oocyte Maturation Prostate Epithelial Cord Elongation System Development Organ Development Positive Regulation Of Cholesterol Homeostasis Regulation Of Metabolic Process Negative Regulation Of Oocyte Development Regulation Of Growth Hormone Receptor Signaling Pathway	Positive Regulation Of Vasodilation Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Vasodilation Signaling Cell Communication Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Cell Proliferation Positive Regulation Of Heart Rate Regulation Of Blood Vessel Size Regulation Of Tube Size Cellular Response To Stimulus Response To Hormone Positive Regulation Of Heart Contraction Cell Activation Positive Regulation Of Metabolic Process Regulation Of CAMP Metabolic Process Response To Peptide Hormone Artery Smooth Muscle Contraction Response To Peptide Regulation Of Kinase Activity Tonic Smooth Muscle Contraction Positive Regulation Of Protein Metabolic Process Response To Insulin Cellular Chemical Homeostasis Positive Regulation Of Signal Transduction Regulation Of Catalytic Activity Second-messenger-mediated Signaling Blood Circulation Response To External Stimulus Intracellular Signal Transduction Response To Stimulus Cellular Response To Hormone Stimulus Response To Organic Substance Regulation Of Vasoconstriction Positive Regulation Of Cellular Metabolic Process Vascular Smooth Muscle Contraction Histamine Secretion Negative Regulation Of Cell Proliferation Regulation Of Signal Transduction Cellular Homeostasis Regulation Of Heart Rate Cellular Metal Ion Homeostasis Response To Abiotic Stimulus Phosphate-containing Compound Metabolic Process Histamine Transport Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Multicellular Organismal Development
Tagcloud ?		biventricle bv cardiomyogenic circuits combinatorial coordinately cpcs dimethylation dissect h3k27 h3k4 hampered hand1 hey hlhs hypoplastic ips maldevelopment malformations nkx2 notch1 pluripotency pluripotent reconstitute reprogrammed signatures sre tbx2 tnnt2	adh alb albinism arbitrarily assortment backcrossing constitution duplicate electrophoretically fumarate glo glucosephosphate glyoxalase gpd homeologous hydratase intersubspecies isocitrate malic mannosephosphate midh mpi numbered phosphorylase provisionally sme sorbitol sord ssod
Tagcloud (Difference) ?		biventricle bv cardiomyogenic circuits combinatorial coordinately cpcs dimethylation dissect h3k27 h3k4 hampered hand1 hey hlhs hypoplastic ips maldevelopment malformations nkx2 notch1 pluripotency pluripotent reconstitute reprogrammed signatures sre tbx2 tnnt2	adh alb albinism arbitrarily assortment backcrossing constitution duplicate electrophoretically fumarate glo glucosephosphate glyoxalase gpd homeologous hydratase intersubspecies isocitrate malic mannosephosphate midh mpi numbered phosphorylase provisionally sme sorbitol sord ssod
Tagcloud (Intersection) ?