LITAF and KCNIP4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LITAF	KCNIP4
Description		lipopolysaccharide induced TNF factor	potassium voltage-gated channel interacting protein 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Endosome Golgi Apparatus Plasma Membrane Cytoplasmic Side Of Plasma Membrane Endosome Membrane Membrane Early Endosome Membrane Late Endosome Membrane Cytoplasmic Side Of Early Endosome Membrane Cytoplasmic Side Of Late Endosome Membrane Cytoplasmic Side Of Lysosomal Membrane	Cytoplasm Peroxisome Endoplasmic Reticulum Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Monoatomic Ion Channel Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding WW Domain Binding	Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity Metal Ion Binding
	Biological Process	Regulation Of Cytokine Production Regulation Of Macrophage Cytokine Production Response To Lipopolysaccharide Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide Negative Regulation Of Non-canonical NF-kappaB Signal Transduction	Monoatomic Ion Transport Potassium Ion Transport Regulation Of Signal Transduction Monoatomic Ion Transmembrane Transport Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport
Pathways			Phase 1 - inactivation of fast Na+ channels
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Colorectal or endometrial cancer ( 26621817) Crohn's disease ( 28067908) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Gallstone disease ( 30504769) Heel bone mineral density ( 30598549) Hip index ( 34021172) Inflammatory bowel disease ( 23128233 28067908) LDL cholesterol levels ( 32203549) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 33339817 32154731) Monocyte percentage of white cells ( 32888494) QT interval ( 19305409 30679814 29874175 29213071 24952745 23166209 19305408) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) TPE interval (resting) ( 32386560) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Appendicular lean mass ( 33097823) Cadmium levels ( 26025379) Colorectal cancer ( 29228715) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 26169577) Diverticular disease ( 30177863) Lingual gyrus volume ( 31530798) Obesity-related traits ( 23251661) Parkinson disease and lewy body pathology ( 25663231) Post bronchodilator FEV1/FVC ratio ( 26634245) Postburn scar height ( 30595539) Rheumatoid arthritis ( 21156761) Suicidal ideation ( 20877300)
Interacting Genes		42 interacting genes: ARID5A ATXN1 BAG3 CALCOCO2 COMT CREB5 DAZAP2 EPN1 EPN2 EPN3 GGA3 HGS HIP1 HPCAL1 HPCAL4 ITCH KCNIP1 KCNIP4 N4BP1 NCALD NEDD4 OPTN POGZ RADIL RASSF3 REEP6 RNF208 RPS27A SMAD2 STAM2 STAT6 TAX1BP1 TNIP1 TNIP3 TOM1 UBA52 UBQLN1 UBQLN2 VENTX VSNL1 WWOX ZIC1	11 interacting genes: APP ASPH COL1A2 GOLGA7 IL17A KCND2 LITAF MEOX2 PSEN1 PSEN2 TRH
Entrez ID		9516	80333
HPRD ID		10354	12184
Ensembl ID		ENSG00000189067	ENSG00000185774
Uniprot IDs		Q99732	A8K4N3 Q3YAB7 Q6PIL6
PDB IDs
Enriched GO Terms of Interacting Partners?		Clathrin Binding Polyubiquitin Modification-dependent Protein Binding Cytosol Ubiquitin Binding Regulation Of Macroautophagy Autophagy Clathrin Vesicle Coat Autophagosome Regulation Of Signal Transduction Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Phosphatidylinositol Binding Positive Regulation Of Catabolic Process Endocytosis Vesicle-mediated Transport Establishment Of Protein Localization To Vacuole ESCRT-0 Complex Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Metabolic Process Cytoplasm Cytoplasmic Vesicle Regulation Of Protein Catabolic Process Regulation Of Autophagy Macroautophagy Protein Targeting To Lysosome Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Localization To Vacuole Endosome Positive Regulation Of Macroautophagy Positive Regulation Of Autophagosome Maturation Import Into Cell Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Early Endosome Membrane Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Phospholipid Binding Protein Transport Protein Targeting To Vacuole Regulation Of Protein Deubiquitination Protein Binding Protein Localization To Lysosome Positive Regulation Of Nucleocytoplasmic Transport Protein-containing Complex Negative Regulation Of Signal Transduction Regulation Of Potassium Ion Transmembrane Transport Protein Tag Activity Regulation Of Autophagosome Maturation	Notch Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Astrocyte Activation Involved In Immune Response Aspartic Endopeptidase Activity, Intramembrane Cleaving Synaptic Membrane Gamma-secretase Complex Positive Regulation Of Protein Transport Notch Receptor Processing Amyloid-beta Formation Neuron Projection Maintenance Skin Morphogenesis Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Protein Trimerization Amyloid Precursor Protein Catabolic Process Regulation Of Amyloid Fibril Formation Astrocyte Activation Regulation Of Calcium Ion Transmembrane Transport Inorganic Ion Homeostasis Positive Regulation Of Glycolytic Process Membrane Protein Ectodomain Proteolysis Amyloid-beta Metabolic Process Positive Regulation Of Amino Acid Transport Amyloid Precursor Protein Metabolic Process Regulation Of Protein Transport Positive Regulation Of Protein Localization Regulation Of Tumor Necrosis Factor Production Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Positive Regulation Of Proteolysis Positive Regulation Of RNA Biosynthetic Process Regulation Of Establishment Of Protein Localization Early Endosome Membrane Positive Regulation Of ATP Metabolic Process Locomotory Behavior Positive Regulation Of DNA-templated Transcription Membrane Protein Proteolysis Dendritic Shaft Calcium Ion Homeostasis Neuron Projection Organization Regulation Of Biological Quality Regulation Of Calcium Ion Transport Positive Regulation Of RNA Metabolic Process Cell-cell Signaling Protein Complex Oligomerization Regulation Of Blood Circulation Cellular Response To Amyloid-beta Signaling
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