LITAF and STAT6

Number of citations of the paper that reports this interaction (PMID 15793005)
23

Data Source:
BioGRID (two hybrid)

		LITAF	STAT6
Gene Name		lipopolysaccharide-induced TNF factor	signal transducer and activator of transcription 6, interleukin-4 induced
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Lysosomal Membrane Golgi Apparatus Plasma Membrane Intracellular Membrane-bounded Organelle	Nuclear Chromatin Nucleoplasm Cytoplasm Cytosol Membrane Raft
	Molecular Function	Signal Transducer Activity Protein Binding WW Domain Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Protein Phosphatase Binding Identical Protein Binding
	Biological Process	Regulation Of Cytokine Production Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Signal Transduction Aging Negative Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Lipopolysaccharide	Negative Regulation Of Transcription From RNA Polymerase II Promoter T-helper 1 Cell Lineage Commitment Negative Regulation Of Type 2 Immune Response Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Positive Regulation Of Type I Interferon Production Mammary Gland Epithelial Cell Proliferation Interleukin-4-mediated Signaling Pathway Regulation Of Cell Proliferation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Isotype Switching To IgE Isotypes Mammary Gland Morphogenesis Cellular Response To Hydrogen Peroxide Cellular Response To Reactive Nitrogen Species
Pathways			Signaling by PDGF Downstream signal transduction Cytosolic sensors of pathogen-associated DNA STING mediated induction of host immune responses STAT6-mediated induction of chemokines Innate Immune System
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) QT interval ( 23166209 19305408 19305409)	Eosinophilic esophagitis (pediatric) ( 20208534) IgE levels ( 22075330)
Protein-Protein Interactions		13 interactors: ATXN1 BAG3 CALCOCO2 COMT HGS ITCH NEDD4 RADIL REEP6 SMAD2 STAM2 STAT6 UBQLN1	37 interactors: ANKZF1 ANXA2 CEBPB CEBPE CEBPZ CREBBP DAZAP2 EEF1A1 EP300 ETS1 HIST2H3C IFNG IL4R IRF4 JAK1 LITAF NCOA1 NCOA2 NFKB1 NMI PPARG PRKCZ PTPN6 RCN3 RELA RLIM SND1 SRC STAT2 STAT3 TP53 TRIM24 VKORC1 WWP1 ZBTB2 ZNF407 ZNF92
Entrez ID		9516	6778
HPRD ID		10354	03302
Ensembl ID		ENSG00000189067	ENSG00000166888
Uniprot IDs		Q99732	A8K4S9 B4DQB3 P42226
PDB IDs			1OJ5
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Signal Transduction Protein Targeting To Lysosome Negative Regulation Of Signaling Response To Stimulus Protein Localization To Lysosome Protein Targeting To Vacuole Signaling Establishment Of Protein Localization To Vacuole Cell Communication Protein K63-linked Ubiquitination Regulation Of Signal Transduction Lysosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Cellular Response To Stimulus Negative Regulation Of Cell Proliferation Negative Regulation Of Cellular Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Signaling Cell Surface Receptor Signaling Pathway Positive Regulation Of Homocysteine Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Cellular Response To Phosphate Starvation Transmission Of Virus Development Involved In Symbiotic Interaction Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Proliferation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vacuolar Transport Regulation Of ERBB Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Homocysteine Metabolic Process T-helper 1 Cell Lineage Commitment Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Interaction With Host Regulation Of Type I Interferon Production Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Negative Regulation Of Dopamine Metabolic Process Zygotic Specification Of Dorsal/ventral Axis Regulation Of Cellular Process Interleukin-4-mediated Signaling Pathway Positive Regulation Of Isotype Switching To IgE Isotypes Negative Regulation Of Transcription, DNA-templated Response To Abiotic Stimulus Signal Transduction Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Learning	Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Gene Expression Regulation Of Gene Expression RNA Metabolic Process Response To Organic Substance Positive Regulation Of Transcription, DNA-templated Defense Response Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Lipid Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Immune Response Cellular Nitrogen Compound Metabolic Process Regulation Of Cytokine Production Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Response To Hormone Response To Stress Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Immune System Process Positive Regulation Of Cytokine Production Response To Cytokine Regulation Of Cellular Process Response To Biotic Stimulus Cellular Response To Hormone Stimulus Cellular Metabolic Process Innate Immune Response Regulation Of Cell Differentiation
Tagcloud ?		16p13 2p13 3p13 abat anomalies cgh cytogenetic determining difficulties disability duplicated duplication duplications dysmorphisms epilepsy facial girl grin2a hotspot intellectual microdeletions novo omim overlapping pmm2 rbfox1 spanning tmem114 vertebral	13r 13ralpha 2rgammac 4r alternative chains classical consist consists crucial exist form forms gammac hand hematopoietic il instead jak1 jak3 lack predominantly recently regard signals transduction transmitted tyrosine utilized
Tagcloud (Difference) ?		16p13 2p13 3p13 abat anomalies cgh cytogenetic determining difficulties disability duplicated duplication duplications dysmorphisms epilepsy facial girl grin2a hotspot intellectual microdeletions novo omim overlapping pmm2 rbfox1 spanning tmem114 vertebral	13r 13ralpha 2rgammac 4r alternative chains classical consist consists crucial exist form forms gammac hand hematopoietic il instead jak1 jak3 lack predominantly recently regard signals transduction transmitted tyrosine utilized
Tagcloud (Intersection) ?