LITAF and STAM2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		LITAF	STAM2
Gene Name		lipopolysaccharide-induced TNF factor	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Lysosomal Membrane Golgi Apparatus Plasma Membrane Intracellular Membrane-bounded Organelle	Nucleoplasm Cytoplasm Cytosol Early Endosome Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Signal Transducer Activity Protein Binding WW Domain Binding	Protein Binding
	Biological Process	Regulation Of Cytokine Production Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Signal Transduction Aging Negative Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Lipopolysaccharide	Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Endosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Membrane Organization
Pathways			Signaling by EGFR EGFR downregulation Endosomal Sorting Complex Required For Transport (ESCRT) Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) QT interval ( 23166209 19305408 19305409)
Protein-Protein Interactions		13 interactors: ATXN1 BAG3 CALCOCO2 COMT HGS ITCH NEDD4 RADIL REEP6 SMAD2 STAM2 STAT6 UBQLN1	34 interactors: ABI2 ARRDC3 ATXN1 CBX5 DAZAP2 EGFR EPS15 FAM189A2 HGS ITCH JAK1 JAK2 JAK3 KLHL42 L3MBTL2 LCP2 LITAF PHF10 PLEKHB2 PTPN1 RNF11 SH2D4A STAMBP TIMM8A TYK2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2H UBQLN4 USP8 VPS37C XRN1
Entrez ID		9516	10254
HPRD ID		10354	05876
Ensembl ID		ENSG00000189067	ENSG00000115145
Uniprot IDs		Q99732	O75886
PDB IDs			1X2Q 1X5B 2L0T
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Signal Transduction Protein Targeting To Lysosome Negative Regulation Of Signaling Response To Stimulus Protein Localization To Lysosome Protein Targeting To Vacuole Signaling Establishment Of Protein Localization To Vacuole Cell Communication Protein K63-linked Ubiquitination Regulation Of Signal Transduction Lysosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Cellular Response To Stimulus Negative Regulation Of Cell Proliferation Negative Regulation Of Cellular Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Signaling Cell Surface Receptor Signaling Pathway Positive Regulation Of Homocysteine Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Cellular Response To Phosphate Starvation Transmission Of Virus Development Involved In Symbiotic Interaction Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Proliferation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vacuolar Transport Regulation Of ERBB Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Homocysteine Metabolic Process T-helper 1 Cell Lineage Commitment Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Interaction With Host Regulation Of Type I Interferon Production Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Negative Regulation Of Dopamine Metabolic Process Zygotic Specification Of Dorsal/ventral Axis Regulation Of Cellular Process Interleukin-4-mediated Signaling Pathway Positive Regulation Of Isotype Switching To IgE Isotypes Negative Regulation Of Transcription, DNA-templated Response To Abiotic Stimulus Signal Transduction Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Learning	Regulation Of Innate Immune Response Innate Immune Response Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Protein K48-linked Ubiquitination Protein Polyubiquitination Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Protein Catabolic Process Immune Response Regulation Of Immune System Process Defense Response Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Protein Catabolic Process Protein Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress JAK-STAT Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of DNA-templated Transcription In Response To Stress Protein Modification By Small Protein Conjugation Activation Of Innate Immune Response Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Toll-like Receptor 4 Signaling Pathway Regulation Of Signal Transduction Regulation Of ERBB Signaling Pathway Positive Regulation Of Innate Immune Response Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Negative Regulation Of Signal Transduction Protein Autophosphorylation Regulation Of Cytokine-mediated Signaling Pathway Cellular Response To Hypoxia
Tagcloud ?		16p13 2p13 3p13 abat anomalies cgh cytogenetic determining difficulties disability duplicated duplication duplications dysmorphisms epilepsy facial girl grin2a hotspot intellectual microdeletions novo omim overlapping pmm2 rbfox1 spanning tmem114 vertebral	adaptors coimmunoprecipitated comprises dok1 epcs epo epor erythroblast erythroblasts gab1 hemoglobinizing homo irs2 orf phosphoproteomics phosphotyrosine primates propagates py rhex sapiens sh2d2a shc1 sprouty spry1 spry2 transducing ut7epo validating
Tagcloud (Difference) ?		16p13 2p13 3p13 abat anomalies cgh cytogenetic determining difficulties disability duplicated duplication duplications dysmorphisms epilepsy facial girl grin2a hotspot intellectual microdeletions novo omim overlapping pmm2 rbfox1 spanning tmem114 vertebral	adaptors coimmunoprecipitated comprises dok1 epcs epo epor erythroblast erythroblasts gab1 hemoglobinizing homo irs2 orf phosphoproteomics phosphotyrosine primates propagates py rhex sapiens sh2d2a shc1 sprouty spry1 spry2 transducing ut7epo validating
Tagcloud (Intersection) ?