LITAF and COMT

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		LITAF	COMT
Gene Name		lipopolysaccharide-induced TNF factor	catechol-O-methyltransferase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Lysosomal Membrane Golgi Apparatus Plasma Membrane Intracellular Membrane-bounded Organelle	Mitochondrion Cytosol Plasma Membrane Membrane Integral Component Of Membrane Axon Dendritic Spine Cell Body Postsynaptic Membrane Extracellular Vesicular Exosome
	Molecular Function	Signal Transducer Activity Protein Binding WW Domain Binding	Magnesium Ion Binding Protein Binding O-methyltransferase Activity Catechol O-methyltransferase Activity
	Biological Process	Regulation Of Cytokine Production Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Signal Transduction Aging Negative Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Lipopolysaccharide	Xenobiotic Metabolic Process Synaptic Transmission Female Pregnancy Learning Short-term Memory Estrogen Metabolic Process Response To Organic Cyclic Compound Cellular Response To Phosphate Starvation Methylation Response To Lipopolysaccharide Developmental Process Negative Regulation Of Renal Sodium Excretion Neurotransmitter Catabolic Process Neurotransmitter Biosynthetic Process Dopamine Catabolic Process Response To Drug Small Molecule Metabolic Process Negative Regulation Of Dopamine Metabolic Process Response To Pain Multicellular Organismal Reproductive Process Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Homocysteine Metabolic Process Regulation Of Sensory Perception Of Pain
Pathways			Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Dopamine clearance from the synaptic cleft Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective UGT1A4 causes hyperbilirubinemia Enzymatic degradation of dopamine by COMT Enzymatic degradation of Dopamine by monoamine oxidase Metabolic disorders of biological oxidation enzymes Phase II conjugation Methylation Defective UGT1A1 causes hyperbilirubinemia Neurotransmitter Clearance In The Synaptic Cleft Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency) Transmission across Chemical Synapses
Drugs			S-Adenosylmethionine Tolcapone Entacapone 3,5-Dinitrocatechol BIA N-{3-[5-(6-Amino-Purin-9-Yl)-3,4-Dihydroxy-Tetrahydro-Furan-2-Yl]-Allyl}-2,3-Dihydroxy-5-Nitro-Benzamide Nialamide (3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONE 7,8-dihydroxy-4-phenyl-2H-chromen-2-one
Diseases
GWAS		Inflammatory bowel disease ( 23128233) QT interval ( 23166209 19305408 19305409)
Protein-Protein Interactions		13 interactors: ATXN1 BAG3 CALCOCO2 COMT HGS ITCH NEDD4 RADIL REEP6 SMAD2 STAM2 STAT6 UBQLN1	10 interactors: ACE CDC27 KRT31 KRT40 KRTAP5-9 LITAF RGS2 TRIP13 VKORC1 XRN2
Entrez ID		9516	1312
HPRD ID		10354	00284
Ensembl ID		ENSG00000189067	ENSG00000093010
Uniprot IDs		Q99732	P21964
PDB IDs			3A7E 3BWM 3BWY
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Signal Transduction Protein Targeting To Lysosome Negative Regulation Of Signaling Response To Stimulus Protein Localization To Lysosome Protein Targeting To Vacuole Signaling Establishment Of Protein Localization To Vacuole Cell Communication Protein K63-linked Ubiquitination Regulation Of Signal Transduction Lysosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Cellular Response To Stimulus Negative Regulation Of Cell Proliferation Negative Regulation Of Cellular Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Signaling Cell Surface Receptor Signaling Pathway Positive Regulation Of Homocysteine Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Cellular Response To Phosphate Starvation Transmission Of Virus Development Involved In Symbiotic Interaction Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Proliferation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vacuolar Transport Regulation Of ERBB Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Homocysteine Metabolic Process T-helper 1 Cell Lineage Commitment Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Interaction With Host Regulation Of Type I Interferon Production Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Negative Regulation Of Dopamine Metabolic Process Zygotic Specification Of Dorsal/ventral Axis Regulation Of Cellular Process Interleukin-4-mediated Signaling Pathway Positive Regulation Of Isotype Switching To IgE Isotypes Negative Regulation Of Transcription, DNA-templated Response To Abiotic Stimulus Signal Transduction Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Learning	Spermatogenesis Male Gamete Generation Gamete Generation Sexual Reproduction Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Reproduction Negative Regulation Of Gap Junction Assembly Cell Proliferation In Bone Marrow Single Organism Reproductive Process Positive Regulation Of Peptidyl-cysteine S-nitrosylation Developmental Process Reproductive Process Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Regulation Of Renal Output By Angiotensin Angiotensin Catabolic Process In Blood Multicellular Organismal Protein Catabolic Process Multicellular Organismal Protein Metabolic Process Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Hematopoietic Stem Cell Proliferation Vitamin K Metabolic Process Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of CAMP-mediated Signaling Hormone Catabolic Process Negative Regulation Of Phospholipase Activity Metaphase/anaphase Transition Of Mitotic Cell Cycle Relaxation Of Vascular Smooth Muscle Relaxation Of Smooth Muscle Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Striated Muscle Contraction Negative Regulation Of Muscle Hypertrophy Angiotensin Maturation Epidermis Development Regulation Of Angiotensin Metabolic Process Peptide Catabolic Process Regulation Of Blood Volume By Renin-angiotensin Hematopoietic Stem Cell Differentiation Arachidonic Acid Secretion Positive Regulation Of Microtubule Polymerization Peptidyl-glutamic Acid Carboxylation Relaxation Of Cardiac Muscle Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Negative Regulation Of Transferase Activity Female Meiosis I Negative Regulation Of NF-kappaB Import Into Nucleus Negative Regulation Of Smooth Muscle Contraction Blood Circulation Positive Regulation Of Protein Autophosphorylation Negative Regulation Of Lipase Activity Neutrophil Mediated Immunity
Tagcloud ?		16p13 2p13 3p13 abat anomalies cgh cytogenetic determining difficulties disability duplicated duplication duplications dysmorphisms epilepsy facial girl grin2a hotspot intellectual microdeletions novo omim overlapping pmm2 rbfox1 spanning tmem114 vertebral	3h altering alters c6 catechol catecholamines dopamine fourfold hek293 heterologous hplc kinetic km metabolizes monoamine neurotransmitter norepinephrine plasmalemmal potencies retention ro saturation serotonin substrates transporter transporters tropolone uptake velocity
Tagcloud (Difference) ?		16p13 2p13 3p13 abat anomalies cgh cytogenetic determining difficulties disability duplicated duplication duplications dysmorphisms epilepsy facial girl grin2a hotspot intellectual microdeletions novo omim overlapping pmm2 rbfox1 spanning tmem114 vertebral	3h altering alters c6 catechol catecholamines dopamine fourfold hek293 heterologous hplc kinetic km metabolizes monoamine neurotransmitter norepinephrine plasmalemmal potencies retention ro saturation serotonin substrates transporter transporters tropolone uptake velocity
Tagcloud (Intersection) ?