PPP1R18 and GFAP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PPP1R18	GFAP
Description		protein phosphatase 1 regulatory subunit 18	glial fibrillary acidic protein
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton	Cytoplasm Lysosome Cytosol Cytoskeleton Intermediate Filament Membrane Cell Projection Cell Body Intermediate Filament Cytoskeleton Glial Cell Projection Astrocyte Projection Astrocyte End-foot Cytoplasmic Side Of Lysosomal Membrane
	Molecular Function	Actin Binding Protein Binding Phosphatase Binding	Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding Kinase Binding Identical Protein Binding
	Biological Process		Intracellular Protein Transport Gene Expression Positive Regulation Of Schwann Cell Proliferation Negative Regulation Of Neuron Projection Development Astrocyte Development Schwann Cell Proliferation Extracellular Matrix Organization Neuron Projection Regeneration Neuron Projection Development Regulation Of Protein-containing Complex Assembly Intermediate Filament-based Process Intermediate Filament Organization Regulation Of Neurotransmitter Uptake Bergmann Glial Cell Differentiation Positive Regulation Of Glial Cell Proliferation Long-term Synaptic Potentiation D-aspartate Import Across Plasma Membrane Regulation Of Chaperone-mediated Autophagy
Pathways			Nuclear signaling by ERBB4 Chaperone Mediated Autophagy
Drugs
Diseases			Alexander disease
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease ( 33909500) Hemoglobin levels ( 32327693) Lung cancer ( 28604730)	Asthma ( 31619474) Cognitive function ( 25644384) Craniofacial microsomia ( 26853712)
Interacting Genes		80 interacting genes: ABRA ACTN3 BICD2 CALCOCO2 CARD9 CBY2 CCDC102B CCDC136 CCDC57 CCDC88B CDR2L CEP70 COG6 DES DZIP1 EIF3L FAM9B FHL5 FSD2 GCC1 GFAP GMCL1 GOLGA2 GOLGA6L9 GOPC GRIPAP1 GTPBP3 HAP1 HOMER3 HOOK2 HSF2BP IKZF3 KASH5 KCTD9 KRT13 KRT15 KRT16 KRT19 KRT27 KRT31 KRT33B KRT34 KRT36 KRT40 LDOC1 LZTS1 LZTS2 MAD1L1 MAPK1 MEOX2 MID2 MRPL38 MTUS2 NACA NEFL PDE4DIP PIBF1 PLEKHF2 PPP1CA PPP1CC PPP1R13B PRPH SORBS3 SPDL1 STX11 TCF4 TEX11 TFIP11 TRAF2 TRIM23 TRIM27 TRIM54 TRIM62 TRIM69 TSC1 TSGA10 VIM VPS52 ZMYND12 ZRANB1	86 interacting genes: ABI2 AKT1 APP AURKB BIRC2 CAMK2A CARD10 CCDC57 CDC37 CDK1 CEP76 CFAP206 CRYAB CT55 CWF19L2 DSCAM ENKD1 EPM2AIP1 FAM50B FXR1 FXR2 GOLGA2 GRAP2 HGS HOMEZ IKBKG ITSN1 KIAA0408 KRT13 KRT15 KRT19 KRT27 KRT31 KRT39 LENG1 LGALS14 LMO2 MAPK9 MEN1 MOS MYBPHL MYO15B NEFL NEIL3 NEK6 NFKBID NTAQ1 NXF1 PDLIM1 PDLIM7 PDZK1 PIAS2 PIH1D2 POM121 PPP1R16B PPP1R18 PRKACA PRKCA PRKCG PSEN1 PSEN2 RIBC2 ROCK1 RORA S100A1 S100B SH3YL1 SMARCA2 SMARCB1 SRC STAT1 TBC1D21 TBC1D22B TFIP11 TLE5 TP53BP2 TRIM27 TSC1 TUBGCP4 UBASH3A UBE3A VIM YES1 ZC2HC1C ZNF655 ZNF774
Entrez ID		170954	2670
HPRD ID		11172	00675
Ensembl ID		ENSG00000146112	ENSG00000131095
Uniprot IDs		A0A024RCJ8 A0A0G2JHC2 Q6NYC8	A0A1X7SBR3 P14136
PDB IDs			6A9P
Enriched GO Terms of Interacting Partners?		Cytoskeleton Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Organization Intermediate Filament Organelle Organization Supramolecular Fiber Organization Structural Constituent Of Skin Epidermis Keratin Filament Structural Constituent Of Cytoskeleton Structural Molecule Activity Protein Binding Identical Protein Binding Intermediate Filament Cytoskeleton Microtubule-based Process Centrosome Morphogenesis Of An Epithelium Microtubule Cytoskeleton Organization Tissue Morphogenesis Cytosol Cytoplasm Microtubule Organizing Center Bergmann Glial Cell Differentiation Epithelial Cell Differentiation Microtubule Organizing Center Organization Negative Regulation Of Viral Transcription Intracellular Transport Developmental Process Regulation Of Viral Transcription Response To Muramyl Dipeptide Cellular Developmental Process Positive Regulation Of Skeletal Muscle Tissue Growth Establishment Of Localization In Cell Developmental Process Involved In Reproduction Establishment Of Protein Localization Dynein Light Intermediate Chain Binding Cytoskeleton-dependent Intracellular Transport Kinetochore Binding Regulation Of Autophagy Cell Differentiation Regulation Of Skeletal Muscle Tissue Growth Z Disc Intracellular Protein Localization Protein Transport Astrocyte Differentiation PTW/PP1 Phosphatase Complex Cellular Localization Organelle Transport Along Microtubule Cellular Response To Muramyl Dipeptide	Cytoskeleton Organization Intermediate Filament Organization Cytoskeleton Supramolecular Fiber Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Protein Binding Protein Serine/threonine/tyrosine Kinase Activity Intracellular Signal Transduction Structural Constituent Of Skin Epidermis Cytoplasm Protein Kinase Activity Intermediate Filament Protein Serine Kinase Activity Regulation Of Cellular Component Organization Microtubule Cytoskeleton Organization Organelle Organization Response To Peptide Hormone Positive Regulation Of Signaling Regulation Of Generation Of Precursor Metabolites And Energy Protein Serine/threonine Kinase Activity Protein-containing Complex Keratin Filament Regulation Of Synaptic Plasticity Protein Phosphorylation Nucleus Kinase Activity Regulation Of Neuronal Synaptic Plasticity Structural Constituent Of Cytoskeleton Response To Hormone Regulation Of Protein Metabolic Process Positive Regulation Of Cell Communication Cytosol Regulation Of Sister Chromatid Segregation Regulation Of Cell Cycle Regulation Of Apoptotic Process Synaptic Membrane Mitotic Nuclear Membrane Disassembly Developmental Process Negative Regulation Of TORC1 Signaling Intracellular Signaling Cassette Regulation Of Proteolysis Phosphorylation Regulation Of Circadian Rhythm Regulation Of Signaling Positive Regulation Of Gene Expression Regulation Of Cell Communication Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Structural Molecule Activity
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